Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
- Product Name
- Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
- CAS No.
- 371945-06-1
- Chemical Name
- Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
- Synonyms
- 3-aminofuro[2,3-b]pyridine-2-carboxylate;ethyl 2-aminofuro[2,3-b]pyridine-3-carboxylate;ethyl 3-amino furo[2,3-b]pyridine-2-carboxylate;Ethyl 3-aminofuro[2,3-B]pyridine-2-carboxylate ,98%;2-amino-3-furo[2,3-b]pyridinecarboxylic acid ethyl ester;3-Amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl este;3-Amino-furano[2,3-B]pyrimidine-2-carboxylate ethyl ester;3-Amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl ester;Furo[2,3-b]pyridine-2-carboxylicacid,3-amino-, ethyl ester;Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
- CBNumber
- CB51045436
- Molecular Formula
- C10H10N2O3
- Formula Weight
- 206.2
- MOL File
- 371945-06-1.mol
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) Property
- Melting point:
- 134 °C
- Boiling point:
- 342.0±37.0 °C(Predicted)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.22±0.40(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A608730
- Product name
- 3-Amino-furo[2,3-b]pyridine-2-carboxylicacidethylester
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0035031
- Product name
- Ethyl3-aminofuro[2,3-b]pyridine-2-carboxylate
- Purity
- 97.03%
- Packaging
- 5g
- Price
- $273
- Updated
- 2021/12/16
- Product number
- W5822
- Product name
- 3-Amino-furo[2,3-b]pyridine-2-carboxylicacidethylester
- Packaging
- 10g
- Price
- $771
- Updated
- 2021/12/16
- Product number
- 072313
- Product name
- 3-Amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl ester
- Purity
- 95+%
- Packaging
- 5g
- Price
- $899
- Updated
- 2021/12/16
- Product number
- CHM0097382
- Product name
- ETHYL-3-AMINOFURO[2,3-B]PYRIDINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $958.65
- Updated
- 2021/12/16
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) Chemical Properties,Usage,Production
Synthesis
6602-54-6
623-50-7
371945-06-1
Using 2-chloro-3-cyanopyridine (2.00 g, 1.0 eq.) and ethyl ethanoate (1.43 mL, 1.05 eq.) as raw materials, CuI (0.05 g, 0.02 eq.) and Cs2CO3 (10.3 g, 2.2 eq.) were added to the reaction mixture under stirring conditions. The reaction system was heated to 70°C and maintained at this temperature for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, slowly poured into deionized water (300 mL), and allowed to stand for 1 hour to promote precipitate formation. Subsequently, the precipitate was collected by filtration, ground with a solvent mixture of ether/hexane (1:1, v/v), and finally dried by azeotropic drying with toluene to afford the target product ethyl 3-amino-furo[2,3-b]pyridine-2-carboxylate (51c, 2.0 g, 70% yield).
References
[1] Patent: US2010/261714, 2010, A1. Location in patent: Page/Page column 75
[2] Synthesis, 2007, # 20, p. 3247 - 3251
[3] Patent: WO2017/90058, 2017, A1. Location in patent: Page/Page column 14
[4] Patent: WO2011/21038, 2011, A1. Location in patent: Page/Page column 18; 24
[5] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 2, p. 138 - 142
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) manufacturers
- Product
- Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) 371945-06-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24