Pyridine, 5-(bromomethyl)-2-chloro- (9CI)
- Product Name
- Pyridine, 5-(bromomethyl)-2-chloro- (9CI)
- CAS No.
- 182924-36-3
- Chemical Name
- Pyridine, 5-(bromomethyl)-2-chloro- (9CI)
- Synonyms
- 5-bromomethyl-2-chloropyridin;5-BROMOMETHYL-2-CHLOROPYRIDINE;6-Chloro-3-bromomethylpyridine;Pyridine, 5-(bromomethyl)-2-chloro-;Pyridine, 5-(bromomethyl)-2-chloro- (9CI);5-(bromomethyl)-2-chloropyridine hydrochloride;5-[methylene- 14C1] (bromomethyl)-2-chloropyridine;Pyridine, 5-(bromomethyl)-2-chloro- (9CI) ISO 9001：2015 REACH
- CBNumber
- CB51060710
- Molecular Formula
- C6H5BrClN
- Formula Weight
- 206.47
- MOL File
- 182924-36-3.mol
Pyridine, 5-(bromomethyl)-2-chloro- (9CI) Property
- Melting point:
- 48-50°C
- Boiling point:
- 262.5±25.0 °C(Predicted)
- Density
- 1.663±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- -0.89±0.10(Predicted)
- form
- Solid
- color
- Pale Yellow
- InChI
- InChI=1S/C6H5BrClN/c7-3-5-1-2-6(8)9-4-5/h1-2,4H,3H2
- InChIKey
- YJOULMMJZAADRY-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(CBr)C=C1
Safety
- RIDADR
- 1759
- HazardClass
- 8
- PackingGroup
- Ⅲ
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B697130
- Product name
- 5-Bromomethyl-2-chloropyridine
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B697130
- Product name
- 5-Bromomethyl-2-chloropyridine
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FB147805
- Product name
- 5-(Bromomethyl)-2-chloropyridine
- Packaging
- 100mg
- Price
- $53
- Updated
- 2021/12/16
- Product number
- FB147805
- Product name
- 5-(Bromomethyl)-2-chloropyridine
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB147805
- Product name
- 5-(Bromomethyl)-2-chloropyridine
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
Pyridine, 5-(bromomethyl)-2-chloro- (9CI) Chemical Properties,Usage,Production
Uses
5-Bromomethyl-2-chloropyridine is a reagent used in the preparation of gonadotropin-releasing hormone receptor antagonist using uracil scaffold.
Synthesis
22536-61-4
182924-36-3
The general procedure for the synthesis of 5-bromomethyl-2-chloropyridine using 2-chloro-5-methylpyrimidine as starting material was as follows: synthetic embodiment 25, N-[1-((2-chloropyrimidin-5-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide (compound 243). 2-Chloro-5-methylpyrimidine (1.04 g, 8.13 mmol) was dissolved in 30 mL of carbon tetrachloride and N-bromosuccinimide (1.73 g, 9.75 mmol) and benzoyl peroxide (20 mg) were added. The mixture was heated to reflux for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 3:1) to afford 5-bromomethyl-2-chloropyridine 641 mg (38% yield).1H-NMR (CDCl3, δ, ppm): 4.42 (2H, s), 8.66 (2H, s).
References
[1] Patent: US2013/150414, 2013, A1. Location in patent: Paragraph 0437
Pyridine, 5-(bromomethyl)-2-chloro- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Pyridine, 5-(bromomethyl)-2-chloro- (9CI) Suppliers
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- sales@carbosynth.com
- Country
- United Kingdom
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View Lastest Price from Pyridine, 5-(bromomethyl)-2-chloro- (9CI) manufacturers
- Product
- Pyridine, 5-(bromomethyl)-2-chloro- (9CI) 182924-36-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
- Product
- Pyridine, 5-(bromomethyl)-2-chloro- (9CI) 182924-36-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23