Talinolol

Product Name: Talinolol
CAS No.: 57460-41-0
Chemical Name: Talinolol
Synonyms: Cordanum;rac-Talinolol ;Racemic talinolol;1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane;1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu;1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea;1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea;(+-)-1-(p-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
CBNumber: CB51073789
Molecular Formula: C20H33N3O3
Formula Weight: 363.49
MOL File: 57460-41-0.mol

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Talinolol Property

Melting point:: 160-162°C
Boiling point:: 520.0±50.0 °C(Predicted)
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 13.82±0.20(Predicted)
color: White to Pale Pink

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Safety

HazardClass: IRRITANT
Toxicity: LD50 in rats, mice (mg/kg): 1180, 593 orally; 54.3, 74.7 i.p.; 29.7, 25.0 i.v. (Femmer)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3412
Product name: Talinolol
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $64.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3412
Product name: Talinolol
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $261
Updated: 2024/03/01

Cayman Chemical

Product number: 16116
Product name: (±)-Talinolol
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16116
Product name: (±)-Talinolol
Purity: ≥95%
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 16116
Product name: (±)-Talinolol
Purity: ≥95%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

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Talinolol Chemical Properties,Usage,Production

Description

(±)-Talinolol is a β₁-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. By blocking β₁-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity. Because its metabolism in human liver microsomes is well understood, (±)-talinolol is useful for examining the activity of the drug-transporting MDR1 gene product P-glycoprotein.

Chemical Properties

Off-White to Pale Pink Solid

Uses

Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.

Definition

ChEBI: Talinolol is a member of ureas.

References

[1] abmann i. the actions of talinolol, a β1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction[j]. current medical research and opinion, 2008, 13(6): 325-342.
[2] trausch b, oertel r, richter k, et al. disposition and bioavailability of the β1‐adrenoceptor antagonist talinolol in man[j]. biopharmaceutics & drug disposition, 1995, 16(5): 403-414.

Talinolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Talinolol Suppliers

Canada 1 China 23 Germany 1 India 1 United Kingdom 1 United States 9 Global 36

Tianjin Zhongtian Xinchuang Technology Co., Ltd.

Tel: 13312191509
Email: 1932163312@qq.com
Country: China
ProdList: 283
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5050
Advantage: 50

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 56902
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32063
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9410
Advantage: 58

57460-41-0, TalinololRelated Search:

1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol

1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol

1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane

Cordanum

Racemic talinolol

rac-Talinolol

1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea

1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu

( -)-1-(4-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylharnstoff

(+-)-1-(p-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea

1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea

Talinolol,Beta Receptor,Adrenergic Receptor,antihypertensive,inhibit,Cordanum,Inhibitor,P-glycoprotein,cardioprotective,P-gp

57460-41-0

C20H33N3O3

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals