ChemicalBook > CAS DataBase List > 4-azetidin-1-yl-2-chloropyrimidine
4-azetidin-1-yl-2-chloropyrimidine
- Product Name
- 4-azetidin-1-yl-2-chloropyrimidine
- CAS No.
- 35691-20-4
- Chemical Name
- 4-azetidin-1-yl-2-chloropyrimidine
- Synonyms
- 4-azetidin-1-yl-2-chloropyrimidine;2-chloro-4-pyrrolidin-1-ylpyrimidine;1-(2-Chloropyrimidin-4-yl)pyrrolidine;Pyrimidine, 2-chloro-4-(1-pyrrolidinyl)-;2-Chloro-4-(pyrrolidin-1-yl)pyrimidine98%;2-Chloro-4-(pyrrolidin-1-yl)pyrimidine 98%
- CBNumber
- CB51077772
- Molecular Formula
- C8H10ClN3
- Formula Weight
- 183.64
- MOL File
- 35691-20-4.mol
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4-azetidin-1-yl-2-chloropyrimidine Property
- storage temp.
- -20°C, stored under nitrogen
- Appearance
- White to off-white Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C379463
- Product name
- 2-Chloro-4-(pyrrolidin-1-yl)pyrimidine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC142714
- Product name
- 2-Chloro-4-(pyrrolidin-1-yl)pyrimidine
- Packaging
- 5G
- Price
- $212.5
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR11552
- Product name
- 2-Chloro-4-(pyrrolidin-1-yl)pyrimidine
- Purity
- 98%
- Packaging
- 5g
- Price
- $312
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 083954
- Product name
- 2-Chloro-4-pyrrolidin-1-ylpyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $341
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-5-J7
- Product name
- 2-Chloro-4-(pyrrolidin-1-yl)pyrimidine
- Purity
- 98.0%
- Packaging
- 5G
- Price
- $344
- Updated
- 2021/12/16
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4-azetidin-1-yl-2-chloropyrimidine Chemical Properties,Usage,Production
Uses
4-(Azetidin-1-yl)-2-chloropyrimidine is a reagent in the preparation of pyrimidinyl biphenylureas as allosteric modulators of the cannabinoid receptor 1 (CB1).
Synthesis
123-75-1
3934-20-1
35691-20-4
GENERAL METHOD: In a 50 mL round-bottomed flask, 2,4-dichloropyrimidine (3.36 mmol) was dissolved in anhydrous ethanol (5 mL), followed by the addition of triethylamine (5.03 mmol) and tetrandrine (5.03 mmol). For the reaction of 2,4-dichloropyrimidine, the mixture was stirred at room temperature; while for the other dichlorodiazines, it was carried out under ethanol reflux conditions. The reaction progress was monitored by gas chromatography (GC). After the starting material 2,4-dichloropyrimidine was completely consumed, the reaction mixture was poured into saturated ammonium chloride solution (20 mL) and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was ground with petroleum ether and filtered through a Büchner funnel to give the pure 2-chloro-4-(pyrrolin-1-yl)pyrimidine.
References
[1] Organic Letters, 2018, vol. 20, # 2, p. 473 - 476
[2] Tetrahedron, 2015, vol. 71, # 29, p. 4859 - 4867
[3] Bioorganic and Medicinal Chemistry Letters, 2018,
[4] European Journal of Medicinal Chemistry, 1991, vol. 26, # 7, p. 729 - 733
[5] Patent: WO2009/29617, 2009, A1. Location in patent: Page/Page column 86-87
4-azetidin-1-yl-2-chloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-azetidin-1-yl-2-chloropyrimidine manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2-Chloro-4-(pyrrolidin-1-yl)pyriMidine 35691-20-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
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