4-methyl-2-chloro-pyrimidine-5-carboxylic acid

Product Name: 4-methyl-2-chloro-pyrimidine-5-carboxylic acid
CAS No.: 188781-10-4
Chemical Name: 4-methyl-2-chloro-pyrimidine-5-carboxylic acid
Synonyms: 5-Carboxy-2-chloro-4-methylpyrimidine;4-methyl-2-chloro-pyrimidine-5-carboxylic acid;2-chloro-4-methyl-5-Pyrimidine carboxylic acid;4-ethyl-2-hydroxy-pyrimidine-5-carboxylic acid;5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-;5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI);5-Carboxy-2-chloro-4-methylpyrimidine, 2-Chloro-4-methyl-1,3-diazine-5-carboxylic acid
CBNumber: CB51082235
Molecular Formula: C6H5ClN2O2
Formula Weight: 172.57
MOL File: 188781-10-4.mol

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4-methyl-2-chloro-pyrimidine-5-carboxylic acid Property

Boiling point:: 375.3±22.0 °C(Predicted)
Density: 1.479±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.06±0.25(Predicted)
form: powder
color: Faint yellow

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C384750
Product name: 2-Chloro-4-methylpyrimidine-5-carboxylicAcid
Packaging: 50mg
Price: $90
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-5-Y7
Product name: 2-Chloro-4-methylpyrimidine-5-carboxylic acid
Packaging: 250mg
Price: $157
Updated: 2021/12/16

Matrix Scientific

Product number: 101837
Product name: 2-Chloro-4-methylpyrimidine-5-carboxylic acid
Purity: 95%
Packaging: 250mg
Price: $212
Updated: 2021/12/16

Matrix Scientific

Product number: 101837
Product name: 2-Chloro-4-methylpyrimidine-5-carboxylic acid
Purity: 95%
Packaging: 500mg
Price: $341
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-5-Y7
Product name: 2-Chloro-4-methylpyrimidine-5-carboxylic acid
Packaging: 1g
Price: $490
Updated: 2021/12/16

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4-methyl-2-chloro-pyrimidine-5-carboxylic acid Chemical Properties,Usage,Production

Synthesis

188781-08-0

188781-10-4

The general procedure for the synthesis of 2-chloro-4-methylpyrimidine-5-carboxylic acid from ethyl 4-methyl-2-chloropyrimidine-5-carboxylate is as follows: Example 9: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate (1.0 g, 5 mmol) was reacted with an aqueous solution (30 mL) of NaOH (0.24 g, 6 mmol) with stirring at room temperature for 3 hours. After completion of the reaction, the reaction solution was acidified with 6N HCl and the precipitated solid was filtered and dried to afford 2-chloro-4-methylpyrimidine-5-carboxylic acid (0.67 g, 78% yield). The product was characterized by 1H NMR (DMSO-d6): δ 9.01 (s, 1H), 2.75 (s, 3H).

References

[1] Journal of medicinal chemistry, 2000, vol. 43, # 21, p. 3995 - 4004
[2] Patent: US5935966, 1999, A
[3] Patent: US5811428, 1998, A

4-methyl-2-chloro-pyrimidine-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-methyl-2-chloro-pyrimidine-5-carboxylic acid Suppliers

China 46 Europe 1 India 2 United Kingdom 1 United States 5 Global 55

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View Lastest Price from 4-methyl-2-chloro-pyrimidine-5-carboxylic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-4-methylpyrimidine-5-carboxylic acid 188781-10-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2025-09-24

Shaanxi Dideu New Materials Co. Ltd

Product: 4-methyl-2-chloro-pyrimidine-5-carboxylic acid 188781-10-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 97.0%
Supply Ability: 10000KGS
Release date: 2025-03-19

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