ChemicalBook > CAS DataBase List > 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE

7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE

Product Name
7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE
CAS No.
24415-66-5
Chemical Name
7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE
Synonyms
Trapidil Impurity 2;7-Chloro-5-methyl-s-triazolo[1,5-a]pyrimidine;7-Chloro-5-methyl-1,2,4-triazolo[1,5-]pyrimidine;7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE;[1,2,4]Triazolo[1,5-a]pyriMidine, 7-chloro-5-Methyl-
CBNumber
CB51091084
Molecular Formula
C6H5ClN4
Formula Weight
168.58
MOL File
24415-66-5.mol
More
Less

7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE Property

Melting point:
151-153 °C
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-0.03±0.30(Predicted)
More
Less

Safety

HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
NC44309
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Packaging
500mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC44309
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Packaging
1g
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC44309
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Packaging
2g
Price
$130
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-QK
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Purity
95%
Packaging
1g
Price
$176
Updated
2021/12/16
Oakwood
Product number
044663
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Purity
97%
Packaging
5g
Price
$180
Updated
2021/12/16
More
Less

7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Uses

7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine is a reactant used in the iron-catalyzed cross-coupling of organometallic compounds.

Synthesis

2503-56-2

24415-66-5

General procedure for the synthesis of 7-chloro-5-methyl-1,2,4-triazolo[1,5-α]pyrimidine from 7-hydroxy-5-methyl-1,3,4-tetraazaindolizine: to a solution of 7-hydroxy-5-methyl-1,3,4-tetraazaindolizine (1.60 g; 10.66 mmol) in dioxane (10 mL) was added sequentially phosphorous triclosulfate (2.5 mL; 26.65 mmol) and triethylamine (2.97 mL; 21.32 mmol). The reaction mixture was heated at 105 °C with stirring for 3 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted slowly and dropwise by adding sodium bicarbonate solution to 8. Subsequently, dichloromethane (DCM) was added for phase separation. The aqueous phase was further extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate and filtered. The solvent was removed by concentration under reduced pressure to give the crude product as an oil. The crude product was purified by column chromatography using a gradient elution from pure petroleum ether to 50% ethyl acetate/petroleum ether to afford 7-chloro-5-methyl-1,2,4-triazolo[1,5-alpha]pyrimidine (Compound 4) as a yellow solid (1.16 g, 65% yield).

References

[1] Tetrahedron Letters, 2018, vol. 59, # 11, p. 1050 - 1054
[2] Patent: WO2007/149211, 2007, A1. Location in patent: Page/Page column 23-24
[3] Monatshefte fuer Chemie, 1987, vol. 118, p. 601 - 606
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 7, p. 1864 - 1872
[5] European Journal of Medicinal Chemistry, 2016, vol. 119, p. 260 - 277

7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE Suppliers

China 57 India 1 Ukraine 2 United Kingdom 1 United States 7 Global 68
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Shanghai Synthfine Chemical Co.,Ltd
Tel
15921303235
Fax
QQ489466966
Email
sales@synthfine.com
Country
China
ProdList
1042
Advantage
58
Shanghai Xiannuo Biotechnology Co., Ltd.
Tel
021-50718719 13918719472
Fax
021-50718719
Country
China
ProdList
979
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Bellen Chemistry Co., Ltd.
Tel
010-60400365-8001 15910885229
Fax
010-60400361
Email
service@bellenchem.com
Country
China
ProdList
4514
Advantage
60
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
4985
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
(5)02557626880
Email
dt3@aikonchem.com
Country
China
ProdList
15493
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
14948
Advantage
58
More
Less

View Lastest Price from 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE manufacturers

Henan Fengda Chemical Co., Ltd
Product
7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE 24415-66-5
Price
US $8.00-2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-25
Career Henan Chemical Co
Product
7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine 24415-66-5
Price
US $1.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
200KG
Release date
2018-08-15

24415-66-5, 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINERelated Search:

7-CHLORO-6-(2-CHLOROETHYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE methyl 7-chloro-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate BUTTPARK 56\40-46 methyl 7-chloro-5-isopropyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE methyl 7-chloro-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate methyl 5-tert-butyl-7-chloro[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate 7-CHLORO-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE 7-chloro-5-pyridin-3-yl[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-isopropyl[1,2,4]triazolo[1,5-a]pyrimidine 5-tert-butyl-7-chloro[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-propyl[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine

  • [1,2,4]Triazolo[1,5-a]pyriMidine, 7-chloro-5-Methyl-
  • 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE
  • 7-Chloro-5-methyl-1,2,4-triazolo[1,5-]pyrimidine
  • 7-Chloro-5-methyl-s-triazolo[1,5-a]pyrimidine
  • Trapidil Impurity 2
  • 24415-66-5
  • Heterocycle-Pyrimidine series