ChemicalBook > CAS DataBase List > 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE

7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE

Product Name
7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE
CAS No.
24415-66-5
Chemical Name
7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE
Synonyms
Trapidil Impurity 2;7-Chloro-5-methyl-s-triazolo[1,5-a]pyrimidine;7-Chloro-5-methyl-1,2,4-triazolo[1,5-]pyrimidine;7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE;[1,2,4]Triazolo[1,5-a]pyriMidine, 7-chloro-5-Methyl-
CBNumber
CB51091084
Molecular Formula
C6H5ClN4
Formula Weight
168.58
MOL File
24415-66-5.mol
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7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE Property

Melting point:
151-153 °C
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-0.03±0.30(Predicted)
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
NC44309
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Packaging
500mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC44309
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Packaging
1g
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC44309
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Packaging
2g
Price
$130
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-QK
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Purity
95%
Packaging
1g
Price
$176
Updated
2021/12/16
Oakwood
Product number
044663
Product name
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
Purity
97%
Packaging
5g
Price
$180
Updated
2021/12/16
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7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Uses

7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine is a reactant used in the iron-catalyzed cross-coupling of organometallic compounds.

Synthesis

2503-56-2

24415-66-5

General procedure for the synthesis of 7-chloro-5-methyl-1,2,4-triazolo[1,5-α]pyrimidine from 7-hydroxy-5-methyl-1,3,4-tetraazaindolizine: to a solution of 7-hydroxy-5-methyl-1,3,4-tetraazaindolizine (1.60 g; 10.66 mmol) in dioxane (10 mL) was added sequentially phosphorous triclosulfate (2.5 mL; 26.65 mmol) and triethylamine (2.97 mL; 21.32 mmol). The reaction mixture was heated at 105 °C with stirring for 3 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted slowly and dropwise by adding sodium bicarbonate solution to 8. Subsequently, dichloromethane (DCM) was added for phase separation. The aqueous phase was further extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate and filtered. The solvent was removed by concentration under reduced pressure to give the crude product as an oil. The crude product was purified by column chromatography using a gradient elution from pure petroleum ether to 50% ethyl acetate/petroleum ether to afford 7-chloro-5-methyl-1,2,4-triazolo[1,5-alpha]pyrimidine (Compound 4) as a yellow solid (1.16 g, 65% yield).

References

[1] Tetrahedron Letters, 2018, vol. 59, # 11, p. 1050 - 1054
[2] Patent: WO2007/149211, 2007, A1. Location in patent: Page/Page column 23-24
[3] Monatshefte fuer Chemie, 1987, vol. 118, p. 601 - 606
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 7, p. 1864 - 1872
[5] European Journal of Medicinal Chemistry, 2016, vol. 119, p. 260 - 277

7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE Suppliers

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View Lastest Price from 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE manufacturers

Henan Fengda Chemical Co., Ltd
Product
7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE 24415-66-5
Price
US $8.00-2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-25
Career Henan Chemical Co
Product
7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine 24415-66-5
Price
US $1.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
200KG
Release date
2018-08-15

24415-66-5, 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINERelated Search:

7-CHLORO-6-(2-CHLOROETHYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE methyl 7-chloro-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate BUTTPARK 56\40-46 methyl 7-chloro-5-isopropyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE methyl 7-chloro-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate methyl 5-tert-butyl-7-chloro[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate 7-CHLORO-5-METHYL-2-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE 7-chloro-5-pyridin-3-yl[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-isopropyl[1,2,4]triazolo[1,5-a]pyrimidine 5-tert-butyl-7-chloro[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-propyl[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidine 7-chloro-5-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine

  • [1,2,4]Triazolo[1,5-a]pyriMidine, 7-chloro-5-Methyl-
  • 7-CHLORO-5-METHYL-1,2,4-TRIAZOLE[1,5-A]PYRIMIDINE
  • 7-Chloro-5-methyl-1,2,4-triazolo[1,5-]pyrimidine
  • 7-Chloro-5-methyl-s-triazolo[1,5-a]pyrimidine
  • Trapidil Impurity 2
  • 24415-66-5
  • Heterocycle-Pyrimidine series