2-CHLORO-3-FLUOROBENZALDEHYDE
- Product Name
- 2-CHLORO-3-FLUOROBENZALDEHYDE
- CAS No.
- 96516-31-3
- Chemical Name
- 2-CHLORO-3-FLUOROBENZALDEHYDE
- Synonyms
- Benzaldehyde, 2-chloro-3-fluoro-;2-CHLORO-3-FLUOROBENZALDEHYDE ISO 9001：2015 REACH
- CBNumber
- CB51092076
- Molecular Formula
- C7H4ClFO
- Formula Weight
- 158.56
- MOL File
- 96516-31-3.mol
2-CHLORO-3-FLUOROBENZALDEHYDE Property
- Melting point:
- 29-32℃
- Boiling point:
- 211.0±20.0℃ (760 Torr)
- Density
- 1.352±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 81.4±21.8℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- color
- White
- Sensitive
- Air Sensitive
Safety
- Hazard Codes
- Xn
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C585758
- Product name
- 2-Chloro-3-fluorobenzaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC67007
- Product name
- 2-Chloro-3-fluorobenzaldehyde
- Packaging
- 50g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- J97737
- Product name
- 2-Chloro-3-fluorobenzaldehyde
- Packaging
- 25g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- 073116
- Product name
- 2-Chloro-3-fluorobenzaldehyde
- Purity
- 95+%
- Packaging
- 10g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FC67007
- Product name
- 2-Chloro-3-fluorobenzaldehyde
- Packaging
- 25g
- Price
- $50
- Updated
- 2021/12/16
2-CHLORO-3-FLUOROBENZALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Clear colourless to light yellow liquid
Synthesis
96516-32-4
96516-31-3
1. To a solution of 2-chloro-3-fluorobenzoic acid (1.00 g, 5.73 mmol) in tetrahydrofuran (THF, 40 ml) was slowly added borane-tetrahydrofuran complex (1.0 M solution, 20.1 ml, 20.1 mmol) at 0 °C. The reaction mixture was stirred under reflux conditions overnight. After completion of the reaction, the mixture was cooled with crushed ice. 2. 1N aqueous hydrochloric acid and ethyl acetate (AcOEt) were added to the cooled reaction mixture to separate the organic and aqueous layers. The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure to give the crude product of (2-chloro-3-fluorophenyl)methanol. 3. To a solution of oxalyl chloride (737 μl, 8.60 mmol) in dichloromethane (CH2Cl2, 50 ml) was slowly added dimethylsulfoxide (DMSO, 1.22 ml, 17.2 mmol) dropwise at -78 °C. The mixture was stirred at the same temperature for 5 min. 4. (2-chloro-3-fluorophenyl) methanol obtained in step 2 was dissolved in dichloromethane (15 ml) and slowly added to the above reaction mixture at -78°C. The reaction solution was warmed to -40°C and stirred for 1 hour. 5. Triethylamine (3.97 ml, 28.7 mmol) was added to the reaction mixture with continued stirring and gradually warmed to room temperature. After completion of the reaction, 0.5N aqueous hydrochloric acid was added and the organic and aqueous layers were separated. 6. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed under reduced pressure and the crude product was purified by column chromatography (eluent: n-hexane/ethyl acetate = 50:1) to give 2-chloro-3-fluorobenzaldehyde (500 mg, 55% yield). 7. The product was analyzed by 1H NMR. 7. The product was confirmed by 1H NMR (CDCl3): δ 7.35-7.43 (2H, m), 7.72-7.78 (1H, m), 10.47 (1H, s).
References
[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 6, p. 1930 - 1949
2-CHLORO-3-FLUOROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-3-FLUOROBENZALDEHYDE manufacturers
- Product
- 2-Chloro-3-fluorobenzaldehyde 96516-31-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-13
- Product
- 2-CHLORO-3-FLUOROBENZALDEHYDE 96516-31-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24