4-AMINO-3-BROMO-2-CHLOROPYRIDINE

Product Name: 4-AMINO-3-BROMO-2-CHLOROPYRIDINE
CAS No.: 215364-85-5
Chemical Name: 4-AMINO-3-BROMO-2-CHLOROPYRIDINE
Synonyms: SA037434;3-Bromo-2-chloro-4-pyridinamine;3-broMo-2-chloropyridin-4-aMine;4-PyridinaMine,3-broMo-2-chloro-;4-AMINO-3-BROMO-2-CHLOROPYRIDINE;3-BroMo-2-chloro-pyridin-4-ylaMine;4-AMino-3-broMo-2-chloropyridine, 97+%;4-AMINO-3-BROMO-2-CHLOROPYRIDINE ISO 9001：2015 REACH;2(1H)-Pyridinone,5,6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-5-piperidinyl)phenyl]-
CBNumber: CB51092278
Molecular Formula: C5H4BrClN2
Formula Weight: 207.46
MOL File: 215364-85-5.mol

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4-AMINO-3-BROMO-2-CHLOROPYRIDINE Property

Melting point:: 150-151°
Boiling point:: 329.0±37.0 °C(Predicted)
Density: 1.834±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 2.73±0.42(Predicted)
form: solid
Appearance: White to off-white Solid
Sensitive: Air Sensitive
InChI: InChI=1S/C5H4BrClN2/c6-4-3(8)1-2-9-5(4)7/h1-2H,(H2,8,9)
InChIKey: KTWAUKYSQFZIET-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(N)=C1Br

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Safety

Hazard Codes: T
Risk Statements: 25-37/38-41
Safety Statements: 26-39-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 751286
Product name: 4-Amino-3-bromo-2-chloropyridine
Purity: 97%
Packaging: 1g
Price: $30.3
Updated: 2023/06/20

TRC

Product number: B699670
Product name: 3-Bromo-2-chloropyridin-4-amine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA148688
Product name: 4-Amino-3-bromo-2-chloropyridine
Packaging: 2g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 047204
Product name: 3-Bromo-2-chloro-4-pyridinamine
Purity: >95%
Packaging: 5g
Price: $97
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0050027
Product name: 4-AMINO-3-BROMO-2-CHLOROPYRIDINE
Purity: 95.00%
Packaging: 250MG
Price: $116.88
Updated: 2021/12/16

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4-AMINO-3-BROMO-2-CHLOROPYRIDINE Chemical Properties,Usage,Production

Uses

4-Amino-3-bromo-2-chloropyridine is an organic compound, which is often used as a synthetic intermediate for certain drugs, including peptide drugs, hormone drugs, anti-tumor drugs, etc. It is also used in the synthesis of dyes.

Synthesis

14432-12-3

215364-85-5

General procedure for the synthesis of 3-bromo-2-chloropyridin-4-amine from 2-chloro-4-aminopyridine: N-bromosuccinimide (NBS, 2.77 g, 15.56 mmol) was added batchwise to a stirred solution of 2-chloropyridin-4-amine (17A, 2 g, 15.56 mmol) in acetic acid (20 mL) at 0 °C and under nitrogen protection. The reaction mixture was then stirred at room temperature for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and azeotropic distillation with ethanol was performed to further remove the residual solvent. The crude product was purified by silica gel column chromatography (using a 40 g RediSep column with a gradient elution using a petroleum ether solution of 10-20% ethyl acetate as eluent) to afford the target compound, 3-bromo-2-chloropyridin-4-amine (15B, 2 g, 9.64 mmol, 62.0% yield), as a white solid.LCMS analysis: m/z = 209.0 [M + H]+; retention time 0.84 min; condition B.

References

[1] Patent: WO2016/133838, 2016, A1. Location in patent: Paragraph 0315
[2] Patent: US2016/16951, 2016, A1. Location in patent: Paragraph 0878; 0879
[3] Patent: WO2008/8539, 2008, A2. Location in patent: Page/Page column 133
[4] Patent: US2014/336182, 2014, A1. Location in patent: Paragraph 0306-0307
[5] Patent: WO2008/124083, 2008, A2. Location in patent: Page/Page column 47

4-AMINO-3-BROMO-2-CHLOROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-3-BROMO-2-CHLOROPYRIDINE Suppliers

China 127 Germany 2 India 3 United Kingdom 2 United States 14 Global 148

Shijiazhuang Dushi Biopharmaceutical Technology Co., Ltd

Tel: 13102890206 18032066297
Email: 3685803652@qq.com
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Shanghai Sunmonth Technology Co., LTD

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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
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future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
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Alfa Aesar

Tel: 400-6106006
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Email: saleschina@alfa-asia.com
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Wuhan Chemwish Technology Co., Ltd

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Capot Chemical Co., Ltd

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Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
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Pharmsynth Pharmaceutical (Chengdu) Technology Co.,LTD

Tel: 15528092102
Fax: On Line QQ 2415375924
Email: Pharmsynth@hotmail.com
Country: China
ProdList: 116
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View Lastest Price from 4-AMINO-3-BROMO-2-CHLOROPYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-AMINO-3-BROMO-2-CHLOROPYRIDINE 215364-85-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Career Henan Chemical Co

Product: 4-AMINO-3-BROMO-2-CHLOROPYRIDINE 215364-85-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-19

215364-85-5, 4-AMINO-3-BROMO-2-CHLOROPYRIDINERelated Search:

6-AMINO-5-BROMO-3-CHLOROPYRIDINE-2-CARBOXAMIDE 5-AMINO-3-BROMO-2-CHLOROPYRIDINE 3-Amino-2-bromo-6-chloropyridine 3-AMINO-5-BROMO-2-CHLOROPYRIDINE 4-AMINO-6-BROMO-3-CHLOROPYRIDINE-2-CARBOXYLIC ACID 3-AMINO-6-BROMO-2-CHLOROPYRIDINE 3-AMINO-2-BROMO-5-CHLOROPYRIDINE 4-AMINO-5-BROMO-2-CHLOROPYRIDINE 6-AMINO-5-BROMO-3-CHLOROPYRIDINE-2-CARBONITRILE 3-Amino-6-bromo-5-chloropyridine,5-Amino-2-bromo-3-chloropyridine 2-Amino-3-bromo-5-chloropyridine 98%,2-AMINO-3-BROMO-5-CHLOROPYRIDINE 2-Bromo-3-hydroxypyridine 4-AMINO-3-BROMO-2-CHLOROPYRIDINE

3-Bromo-2-chloro-4-pyridinamine

4-AMINO-3-BROMO-2-CHLOROPYRIDINE

3-broMo-2-chloropyridin-4-aMine

3-BroMo-2-chloro-pyridin-4-ylaMine

4-AMino-3-broMo-2-chloropyridine, 97+%

4-PyridinaMine,3-broMo-2-chloro-

SA037434

4-AMINO-3-BROMO-2-CHLOROPYRIDINE ISO 9001：2015 REACH

2(1H)-Pyridinone,5,6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-5-piperidinyl)phenyl]-

215364-85-5

Heterocycle-Pyridine series

Boronic Acid

Pyridine