AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2

Product Name: AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
CAS No.: 475221-20-6
Chemical Name: AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
Synonyms: NEP1-40;NOGO-66 (1-40);PubChem ID: 90488731;Nogo Extracellular Peptide;M.W. 4625.11 C206H324N56O65;NOGO EXTRACELLULAR PEPTIDE, 1-40;NOGO-66 (1-40) ANTAGONIST PEPTIDE;NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40;AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2;ARG-ILE-TYR-LYS-GLY-VAL-ILE-GLN-ALA-ILE-GLN-LYS-SER-ASP-GLU-GLY-HIS-PRO-PHE-ARG-ALA-TYR-LEU-GLU-SER-GLU-VAL-ALA-ILE-SER-GLU-GLU-LEU-VAL-GLN-LYS-TYR-SER-ASN-SER-NH2
CBNumber: CB5110481
Molecular Formula: C206H324N56O65
Formula Weight: 4625.11
MOL File: 475221-20-6.mol

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AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Property

storage temp.: -20°C
solubility: H₂O: 1 mg/mL
form: solid
color: white
Water Solubility: Soluble to 1 mg/ml in water

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N7161
Product name: Nogo-66(1-40) antagonist peptide
Purity: ≥84% (HPLC)
Packaging: 1mg
Price: $231.2
Updated: 2024/03/01

Tocris

Product number: 1984
Product name: Nogo-66(1-40)
Packaging: 1
Price: $374
Updated: 2021/12/16

ApexBio Technology

Product number: B5247
Product name: Nogo-66(1-40)
Packaging: 1mg
Price: $549
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0003973
Product name: NOGO-66(1-40) ANTAGONIST PEPTIDE
Purity: 95.00%
Packaging: 1MG
Price: $859.85
Updated: 2021/12/16

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AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Chemical Properties,Usage,Production

Uses

Nogo-66(1-40) antagonist peptide has been used as a Nogo-66 receptor antagonist peptide:

to study the preliminary therapeutic effect after inhibition of Nogo-A in the cauda equina compression (CEC) model
to determine the effects of Nogo-A/NgR1 on autophagic activation
to study its role in Nogo-B mediated axonal branching using Schwann cells and sensory neurons of mice

Biochem/physiol Actions

Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent.

storage

Store at -20°C

AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Suppliers

China 44 Europe 1 Germany 2 Switzerland 1 United Kingdom 1 United States 6 USA 1 Global 56

3B Pharmachem (Wuhan) International Co.,Ltd.

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475221-20-6, AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2Related Search:

AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2

ARG-ILE-TYR-LYS-GLY-VAL-ILE-GLN-ALA-ILE-GLN-LYS-SER-ASP-GLU-GLY-HIS-PRO-PHE-ARG-ALA-TYR-LEU-GLU-SER-GLU-VAL-ALA-ILE-SER-GLU-GLU-LEU-VAL-GLN-LYS-TYR-SER-ASN-SER-NH2

AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2

M.W. 4625.11 C206H324N56O65

NEP1-40

NOGO-66 (1-40)

NOGO-66 (1-40) ANTAGONIST PEPTIDE

NOGO EXTRACELLULAR PEPTIDE, 1-40

PubChem ID: 90488731

NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40

Nogo Extracellular Peptide

L-Serinamide,n2-acetyl-L-arginyl-L-isoleucyl-L-tyrosyl-L-Lysylglycyl-L-valyl-L-isoleucyl-L-glutaminyl-L-alanyl-L-isoleucyl-L-glutaminyl-L-Lysyl-L-seryl-L-a-aspartyl-L-a-glutamylglycyl-l-histidyl-l-pro

Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2

475221-20-6

C206H324N56O65

Various Peptides