Talampicillin hydrochloride
- Product Name
- Talampicillin hydrochloride
- CAS No.
- 39878-70-1
- Chemical Name
- Talampicillin hydrochloride
- Synonyms
- Talat;PC 183;Talpen;BRL 8988;Yamacillin;Aseocillin;Ampicillin Impurity 26;D-Talampicillin hydrochloride;Talampicillin hydrochloride CRS;Ampicillinphthalidyl hydrochloride
- CBNumber
- CB51105387
- Molecular Formula
- C24H23N3O6S.ClH
- Formula Weight
- 517.988
- MOL File
- 39878-70-1.mol
Talampicillin hydrochloride Property
- Melting point:
- 154-157° (dec)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T0010000
- Product name
- Talampicillin hydrochloride
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- t0010000
- Price
- $150
- Updated
- 2024/03/01
- Product number
- API0016125
- Product name
- TALAMPICILLIN HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $280.35
- Updated
- 2021/12/16
Talampicillin hydrochloride Chemical Properties,Usage,Production
Description
Talampicillin was synthesized by Yamanouchi Pharmaceutical Co. in 1971 by esterifying the carboxylic acid group of ampicillin in order to improve the oral absorption. When administered orally, it is hydrolyzed to ampicillin by intestinal esterase. Its bioavailability is two or more times as high as that of ampicillin, and it is used to treat the same infections as those for which ampicillin is used orally but in doses only half or one-third as large.
Originator
Talpen,Beecham,US,1975
Manufacturing Process
A fine suspension of 25.18 grams (0.05 mol) of potassium salt of enamine protected ampicillin and 10.65 grams (0.05 mol) 3-bromophthalide were reacted in a 1:2 mixture of acetone/ethyl acetate (1,500 ml) for 24 hours. After filtration the organic layer was washed twice with 250 ml portions of 1 N sodium bicarbonate and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo. Addition of ether crystallized the phthalide enamine protected α-aminophenylacetamido penicillanate in 85% yield.
Therapeutic Function
Antibacterial
Talampicillin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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