ChemicalBook > CAS DataBase List > 2-Methoxy-4-trifluoromethyl-pyridine

2-Methoxy-4-trifluoromethyl-pyridine

Product Name
2-Methoxy-4-trifluoromethyl-pyridine
CAS No.
219715-34-1
Chemical Name
2-Methoxy-4-trifluoromethyl-pyridine
Synonyms
2-Methoxy-4-trifluoromethyl-pyridine;Pyridine,2-methoxy-4-(trifluoromethyl)-;2-Methoxy-4-trifluoromethyl-pyridine ISO 9001:2015 REACH
CBNumber
CB51113179
Molecular Formula
C7H6F3NO
Formula Weight
177.12
MOL File
219715-34-1.mol
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2-Methoxy-4-trifluoromethyl-pyridine Property

Boiling point:
172.9±40.0 °C(Predicted)
Density 
1.263±0.06 g/cm3(Predicted)
vapor pressure 
7.398-7.399hPa at 25℃
storage temp. 
Sealed in dry,Room Temperature
pka
1.04±0.10(Predicted)
EPA Substance Registry System
Pyridine, 2-methoxy-4-(trifluoromethyl)- (219715-34-1)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Signal word
Warning
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N-Bromosuccinimide Price

TRC
Product number
M271978
Product name
2-Methoxy-4-(trifluoromethyl)pyridine
Packaging
250mg
Price
$145
Updated
2021/12/16
AK Scientific
Product number
V1372
Product name
2-Methoxy-4-trifluoromethylpyridine
Packaging
1g
Price
$171
Updated
2021/12/16
Matrix Scientific
Product number
119913
Product name
2-Methoxy-4-(trifluoromethyl)pyridine
Purity
95+%
Packaging
1g
Price
$324
Updated
2021/12/16
Apolloscientific
Product number
PC201198
Product name
2-Methoxy-4-(trifluoromethyl)pyridine
Purity
98%
Packaging
5g
Price
$450
Updated
2021/12/16
AK Scientific
Product number
V1372
Product name
2-Methoxy-4-trifluoromethylpyridine
Packaging
5g
Price
$457
Updated
2021/12/16
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2-Methoxy-4-trifluoromethyl-pyridine Chemical Properties,Usage,Production

Uses

2-Methoxy-4-(trifluoromethyl)pyridine

Synthesis

124-41-4

81565-18-6

219715-34-1

In a dry reaction flask, 2-chloro-4-trifluoromethylpyridine (45.5 g, 0.251 mol) and a 30% mass fraction of sodium methanol solution (135.5 g, 0.753 mol) were added. The mixture was stirred well and then heated to 65 °C and maintained at that temperature for the reaction. The progress of the reaction was monitored by gas chromatography (GC) until complete conversion of the feedstock. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered to remove insoluble material. Subsequently, methanol was recovered by distillation under reduced pressure. Water was added to the residue and extracted with dichloromethane to separate the organic and aqueous phases. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the light yellow liquid product 2-methoxy-4-trifluoromethylpyridine (40.9 g, 92.1% yield).

References

[1] Patent: CN108558744, 2018, A. Location in patent: Paragraph 0052-0055
[2] Patent: EP1559320, 2005, A1. Location in patent: Page/Page column 9

2-Methoxy-4-trifluoromethyl-pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxy-4-trifluoromethyl-pyridine Suppliers

Pure Chemistry Scientific Inc.
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Focus Synthesis LLC
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View Lastest Price from 2-Methoxy-4-trifluoromethyl-pyridine manufacturers

Dideu Industries Group Limited
Product
2-Methoxy-4-trifluoromethyl-pyridine 219715-34-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-30
Career Henan Chemical Co
Product
2-Methoxy-4-trifluoromethyl-pyridine 219715-34-1
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-01-08