(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Product Name: (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
CAS No.: 114676-69-6
Chemical Name: (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
Synonyms: (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;Boc-cis-4-Hydroxy-D-proline methyl ester;1-tert-butyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;Boc-Cis-D-Hyp-OMe;cis-Boc-d-Hyp-Ome;N-Boc-cis-D-Hyp-Ome;(2R,4R)-1-Boc-4-hydroxypyrroL;CIS-1-BOC-4-HYDROXY-D-PROLINATE;(Tert-Butoxy)Carbonyl D-cis-Hyp-OMe;Methyl cis-Boc-4-hydroxy-D-prolinate
CBNumber: CB51118684
Molecular Formula: C11H19NO5
Formula Weight: 245.27
MOL File: 114676-69-6.mol

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(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Property

Melting point:: 76 °C
Boiling point:: 335.2±42.0 °C(Predicted)
alpha: 63° (C=1,EtOH)
Density: 1.216±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 14.27±0.40(Predicted)
form: Powder
color: White
InChI: InChI=1S/C11H19NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h7-8,13H,5-6H2,1-4H3/t7-,8-/m1/s1
InChIKey: MZMNEDXVUJLQAF-HTQZYQBOSA-N
SMILES: N1(C(OC(C)(C)C)=O)C[C@H](O)C[C@@H]1C(OC)=O

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5857
Product name: N-(tert-Butoxycarbonyl)-cis-4-hydroxy-D-proline Methyl Ester
Purity: >97.0%(GC)
Packaging: 1g
Price: $19
Updated: 2025/07/31

TCI Chemical

Product number: B5857
Product name: N-(tert-Butoxycarbonyl)-cis-4-hydroxy-D-proline Methyl Ester
Purity: >97.0%(GC)
Packaging: 5g
Price: $43
Updated: 2025/07/31

TRC

Product number: M220398
Product name: Methylcis-1-Boc-4-hydroxy-D-prolinate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Oakwood

Product number: 040905
Product name: Methylcis-N-Boc-4-hydroxy-D-prolinate
Purity: 95%
Packaging: 1g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: X4671
Product name: Methylcis-1-Boc-4-hydroxy-D-prolinate
Packaging: 1g
Price: $14
Updated: 2021/12/16

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(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Chemical Properties,Usage,Production

Uses

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate (N-Boc-cis-4-hydroxy-D-proline methyl ester) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

IC 50

Non-cleavable Linker

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Suppliers

Americas 1 China 188 Europe 1 India 6 Japan 1 United Kingdom 1 United States 15 Global 213

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

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View Lastest Price from (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: N-tert-Butoxycarbonyl-cis-4-hydroxy-D-proline methyl ester 114676-69-6
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-01

Career Henan Chemical Co

Product: METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE 114676-69-6
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 97-99%
Supply Ability: 1000KGS
Release date: 2019-12-19

114676-69-6, (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Related Search:

(1s,3s)-methyl 3-aminocyclobutane carboxylate hydrochloride tert-butyl (cis-3-aminocy... cis-cyclopentane-1,2-diamine dihydrochloride cis-2-(Ethoxycarbonyl)cyclopropanecarboxylic acid cis-cyclopropanecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester (+)-CIS-(2R,3S)-3-Hydroxyproline (2S,3R)-3-Hydroxyproline Cis-4-Cyclohexylcyclohexanol (2S,3R)-methyl 3-hydroxypyrrolidine-2-carboxylate hydrochloride (1S,2S)-2-fluorocyclopropanecarboxylic acid cis-3-Hydroxycyclobutanecarboxylic acid rel-(4aR,7aR)-6-Benzyloctahydro-1H-pyrrolo[3,4-b]pyridine CIS-DICHLOROBIS(2,2'-BIPYRIDINE)RUTHENIUM (II) DIHYDRATE, 99 Cyclopropanecarboxylicacid,2-amino-,cis-(9CI) cis-4-Hydroxy-D-proline (S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate BOC-N-methyl-D-alanine

(2R,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylicacid 1-(1,1-dimethylethyl) 2-methyl ester

(2R,4R)-1-tert-butyl 2-Methyl 4-hydroxypyrrolidine-1,2-dicarboxy

(2R,4R)-1-tert-butyl 2-Methyl 4-hydro×ypyrrolidine-1,2-dicarbo×ylate

Boc-Cis-D-Hyp-OMe

Methy cis-1-Boc-4-hydroxy-D-prolinate

Methyl cis-Boc-4-hydroxy-D-prolinate

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-

1-tert-butyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate

N-tert-Butoxycarbonyl-cis-4-hydroxy-D-proline methyl ester

Methyl cis-1-Boc-4-hydroxy-D-prolinate

(2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

N-Boc-cis-4-hydroxy-D-proline methyl ester

Boc-cis-4-Hydroxy-D-proline methyl ester

(Tert-Butoxy)Carbonyl D-cis-Hyp-OMe

CIS-1-BOC-4-HYDROXY-D-PROLINATE

Methyl (2R,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate

(2R,4R)-N-Boc-4-hydroxyproline methyl ester

(2R,4R)-N-Boc-cis-4-hydroxy-D-proline methyl ester

N-Boc-cis-D-Hyp-Ome

(2R,4R)-1-Boc-4-hydroxypyrroL

N-Boc-cis-4-hydroxy-D-prolinemethylester,95%

(2R,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester

METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE USP/EP/BP

O1-tert-Butyl O2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate

cis-Boc-d-Hyp-Ome

1-(1,1-Dimethylethyl) 2-methyl (2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

BOC cis D hydroxyproline methyl ester

(2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate/METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE

Methyl cis-1-Boc-4-hydroxy-D-prolinate, CAS 114676-69-6

1-(tert-Butyl) 2-methyl (2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

114676-69-6