(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE

Product Name: (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
CAS No.: 930782-89-1
Chemical Name: (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
Synonyms: (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE;(R)-1-Boc-4-Cbz-2-(hydroxymethyl)piperazine;(R)-4-Benzyl 1-tert-butyl 2-(hydroxyMethyl)piperazine-1,4-dicarboxylate;4-O-benzyl 1-O-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate;Benzyl 1-((tert-butoxy)carbonyl)-(2R)-2-(hydroxymethyl)piperazine-4-carboxylate;(R)-2-Hydroxymethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester;1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2R)-
CBNumber: CB51118699
Molecular Formula: C18H26N2O5
Formula Weight: 350.41
MOL File: Mol file

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(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Property

Boiling point:: 480.5±30.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.97±0.10(Predicted)
Appearance: Colorless to off-white Viscous liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CCH0003499
Product name: (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
Purity: 95.00%
Packaging: 1G
Price: $269.85
Updated: 2021/12/16

AK Scientific

Product number: Z2817
Product name: 4-Benzyl1-tert-butyl(2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate
Packaging: 5g
Price: $532
Updated: 2021/12/16

Chemenu

Product number: CM277862
Product name: (R)-4-Benzyl1-tert-butyl2-(hydroxymethyl)piperazine-1,4-dicarboxylate
Purity: 95+%
Packaging: 5g
Price: $398
Updated: 2021/12/16

Alichem

Product number: 930782891
Product name: (R)-4-Benzyl1-tert-butyl2-(hydroxymethyl)piperazine-1,4-dicarboxylate
Packaging: 5g
Price: $400
Updated: 2021/12/16

Crysdot

Product number: CD11010990
Product name: (R)-4-Benzyl1-tert-butyl2-(hydroxymethyl)piperazine-1,4-dicarboxylate
Purity: 97%
Packaging: 5g
Price: $422
Updated: 2021/12/16

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(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Chemical Properties,Usage,Production

Synthesis

138775-02-7

930782-89-1

General procedure for the synthesis of R-4-Boc-1-Cbz-2-hydroxymethylpiperazine from (R)-N-1-Boc-N-4-Cbz-2-piperazinecarboxylic acid: (2R)-4-[(phenylmethoxy)carbonyl]-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (1.4 g, 3.9 mmol) was dissolved in dimethoxyethane (10 mL), cooled, and N-methylmorpholine (0.4 g, 3.9 mmol) was added dropwise to the solution. N-methylmorpholine (0.4 g, 3.9 mmol) was added dropwise to the solution, followed by isobutyl chloroformate (0.54 g, 3.9 mmol). The reaction mixture was stirred at 0 °C for 20 min and then filtered. The filtrate was transferred to a 500 mL flask and cooled again. Sodium borohydride (0.22 g, 5.9 mmol) dissolved in water (5 mL) was added to the cooled filtrate and the external cooling bath was removed. The reaction mixture was stirred until its temperature rose to room temperature, then water (120 mL) was added. The mixture was extracted three times with ethyl acetate, the organic phases were combined, dried and the solvent evaporated. The product was purified by silica gel column chromatography (eluent: ethyl acetate/heptane, 10% to 70% gradient elution) to afford 1.2 g (84% yield) of 4-benzyl 1-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate as a colorless oil.1H NMR (500 MHz, CDCl3): δ 1.4 (s, 9H), 2.7-3.2 (b , 4H), 3.5 (b, 2H), 3.8-4.2 (m, 4H), 5.1 (m, 2H), 7.2-7.4 (m, 5H); LCMS: m/z 349 (M-1).

References

[1] Patent: WO2007/37743, 2007, A1. Location in patent: Page/Page column 47

(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (R)-4-Benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 930782-89-1
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-29

Career Henan Chemical Co

Product: (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE 930782-89-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-23

Career Henan Chemical Co

Product: (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE 930782-89-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-23

930782-89-1, (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Related Search:

(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE

(R)-2-Hydroxymethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Benzyl 1-((tert-butoxy)carbonyl)-(2R)-2-(hydroxymethyl)piperazine-4-carboxylate

(R)-4-Benzyl 1-tert-butyl 2-(hydroxyMethyl)piperazine-1,4-dicarboxylate

1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2R)-

(R)-1-Boc-4-Cbz-2-(hydroxymethyl)piperazine

4-O-benzyl 1-O-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate

930782-89-1