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(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE

Product Name
(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
CAS No.
930782-89-1
Chemical Name
(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
Synonyms
(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE;(R)-1-Boc-4-Cbz-2-(hydroxymethyl)piperazine;(R)-4-Benzyl 1-tert-butyl 2-(hydroxyMethyl)piperazine-1,4-dicarboxylate;4-O-benzyl 1-O-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate;Benzyl 1-((tert-butoxy)carbonyl)-(2R)-2-(hydroxymethyl)piperazine-4-carboxylate;(R)-2-Hydroxymethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester;1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2R)-
CBNumber
CB51118699
Molecular Formula
C18H26N2O5
Formula Weight
350.41
MOL File
Mol file
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(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Property

Boiling point:
480.5±30.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.97±0.10(Predicted)
Appearance
Colorless to off-white Viscous liquid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CCH0003499
Product name
(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
Purity
95.00%
Packaging
1G
Price
$269.85
Updated
2021/12/16
AK Scientific
Product number
Z2817
Product name
4-Benzyl1-tert-butyl(2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate
Packaging
5g
Price
$532
Updated
2021/12/16
Chemenu
Product number
CM277862
Product name
(R)-4-Benzyl1-tert-butyl2-(hydroxymethyl)piperazine-1,4-dicarboxylate
Purity
95+%
Packaging
5g
Price
$398
Updated
2021/12/16
Alichem
Product number
930782891
Product name
(R)-4-Benzyl1-tert-butyl2-(hydroxymethyl)piperazine-1,4-dicarboxylate
Packaging
5g
Price
$400
Updated
2021/12/16
Crysdot
Product number
CD11010990
Product name
(R)-4-Benzyl1-tert-butyl2-(hydroxymethyl)piperazine-1,4-dicarboxylate
Purity
97%
Packaging
5g
Price
$422
Updated
2021/12/16
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(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Chemical Properties,Usage,Production

Synthesis

138775-02-7

930782-89-1

General procedure for the synthesis of R-4-Boc-1-Cbz-2-hydroxymethylpiperazine from (R)-N-1-Boc-N-4-Cbz-2-piperazinecarboxylic acid: (2R)-4-[(phenylmethoxy)carbonyl]-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (1.4 g, 3.9 mmol) was dissolved in dimethoxyethane (10 mL), cooled, and N-methylmorpholine (0.4 g, 3.9 mmol) was added dropwise to the solution. N-methylmorpholine (0.4 g, 3.9 mmol) was added dropwise to the solution, followed by isobutyl chloroformate (0.54 g, 3.9 mmol). The reaction mixture was stirred at 0 °C for 20 min and then filtered. The filtrate was transferred to a 500 mL flask and cooled again. Sodium borohydride (0.22 g, 5.9 mmol) dissolved in water (5 mL) was added to the cooled filtrate and the external cooling bath was removed. The reaction mixture was stirred until its temperature rose to room temperature, then water (120 mL) was added. The mixture was extracted three times with ethyl acetate, the organic phases were combined, dried and the solvent evaporated. The product was purified by silica gel column chromatography (eluent: ethyl acetate/heptane, 10% to 70% gradient elution) to afford 1.2 g (84% yield) of 4-benzyl 1-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate as a colorless oil.1H NMR (500 MHz, CDCl3): δ 1.4 (s, 9H), 2.7-3.2 (b , 4H), 3.5 (b, 2H), 3.8-4.2 (m, 4H), 5.1 (m, 2H), 7.2-7.4 (m, 5H); LCMS: m/z 349 (M-1).

References

[1] Patent: WO2007/37743, 2007, A1. Location in patent: Page/Page column 47

(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Suppliers

China 30 India 1 United Kingdom 1 United States 2 Global 34
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(R)-4-Benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate 930782-89-1
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-29
Career Henan Chemical Co
Product
(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE 930782-89-1
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-23
Career Henan Chemical Co
Product
(R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE 930782-89-1
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-23

930782-89-1, (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE Related Search:


  • (R)-4-BOC-1-CBZ-2-HYDROXYMETHYLPIPERAZINE
  • (R)-2-Hydroxymethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester
  • Benzyl 1-((tert-butoxy)carbonyl)-(2R)-2-(hydroxymethyl)piperazine-4-carboxylate
  • (R)-4-Benzyl 1-tert-butyl 2-(hydroxyMethyl)piperazine-1,4-dicarboxylate
  • 1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2R)-
  • (R)-1-Boc-4-Cbz-2-(hydroxymethyl)piperazine
  • 4-O-benzyl 1-O-tert-butyl (2R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate
  • 930782-89-1