8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline

Product Name: 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
CAS No.: 100331-89-3
Chemical Name: 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline
Synonyms: 8-(benzyloxy)-5-(2-broMoacetyl)quinolin-2(1H)-one;5-(2-Bromoacetyl)-8-benzyloxy-1H-quinolin-2-one;1-[8-(b;8-Benzyloxy-5;Indacaterol int;Indacaterol Impurity 37;Indacaterol Intermediate 2;Adatero and its intermediates;5-BroMoacetyl-8-benzyloxycarbostyril;5-Bromoacetyl-8-benzyloxy-2-quinolone
CBNumber: CB51119227
Molecular Formula: C18H14BrNO3
Formula Weight: 372.21
MOL File: 100331-89-3.mol

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8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Property

Melting point:: 192-194oC
Boiling point:: 602.6±55.0 °C(Predicted)
Density: 1.479±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
pka: 10.38±0.70(Predicted)
form: Solid
color: White to Pale Beige
Stability:: Unstable in DMSO
InChI: InChI=1S/C18H14BrNO3/c19-10-15(21)13-6-8-16(18-14(13)7-9-17(22)20-18)23-11-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,20,22)
InChIKey: RVHSDLUBNZBRMH-UHFFFAOYSA-N
SMILES: N1C2=C(C(C(CBr)=O)=CC=C2OCC2=CC=CC=C2)C=CC1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: B286115
Product name: 8-Benzyloxy-5-(2-bromoacetyl)-2(1H)-quinolinone
Packaging: 10mg
Price: $70
Updated: 2021/12/16

TRC

Product number: B286115
Product name: 8-Benzyloxy-5-(2-bromoacetyl)-2(1H)-quinolinone
Packaging: 100mg
Price: $265
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18407
Product name: 8-Benzyloxy- 5-(2-bromoacetyl)-2(1H)-quinolinone
Packaging: 250mg
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18407
Product name: 8-Benzyloxy- 5-(2-bromoacetyl)-2(1H)-quinolinone
Packaging: 500mg
Price: $190
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18407
Product name: 8-Benzyloxy- 5-(2-bromoacetyl)-2(1H)-quinolinone
Packaging: 1g
Price: $300
Updated: 2021/12/16

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8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Chemical Properties,Usage,Production

Chemical Properties

Off-white Solid

Uses

8-(benzyloxy)-5-(2-broMoacetyl)quinolin-2(1H)-one can be used in the preparation of phenylethanolamine derivatives as β2 adrenoreceptor agonists.

Synthesis

93609-84-8

100331-89-3

(1) A bromine solution was prepared by dissolving 7.8 g of bromine in 30 mL of dichloromethane. In another reaction flask, 13 g of 5-acetyl-8-benzyloxy-1H-quinolin-2-one and 7.56 g of boron trifluoride ether compound were dissolved in 170 ml of dichloromethane and heated to reflux. Subsequently, the bromine solution was slowly added dropwise to the refluxed solution and the reflux reaction was continued for 30 minutes. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was adjusted to alkaline by adding 10% aqueous potassium carbonate solution and the resulting precipitate was collected by filtration. The resulting crude product was purified by recrystallization from a solvent mixture of chloroform and methanol, resulting in 12.51 g of 5-bromoacetyl-8-benzyloxy-1H-quinolin-2-one as light yellow acicular crystals in 75.7% yield.

References

[1] Patent: US4579854, 1986, A
[2] Patent: WO2012/168349, 2012, A1. Location in patent: Page/Page column 30-31
[3] Patent: WO2012/168359, 2012, A1. Location in patent: Page/Page column 56; 57
[4] Patent: US2013/34504, 2013, A1. Location in patent: Paragraph 0120; 0121; 0122
[5] Patent: US2014/163066, 2014, A1. Location in patent: Paragraph 0209-0211

8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline Suppliers

Canada 1 China 214 India 4 United Kingdom 1 United States 10 Global 230

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View Lastest Price from 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: 8-BENZYLOXY-5-(2-BROMOACETYL)-2-HYDROXYQUINOLINE 100331-89-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1200KG/M
Release date: 2023-08-11

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 8-BENZYLOXY-5-(2-BROMOACETYL)-2-HYDROXYQUINOLINE 100331-89-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-09

S&Y Biochem Co.,Ltd

Product: 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline 100331-89-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 1111
Release date: 2024-10-08

100331-89-3, 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinolineRelated Search:

INDENO(1,2,3-C,D)PYRENE 6-Bromomethyl-3,4-dihydro-2-methyl-quinazolin-4-one 5-Acetyl-8-(phenylmethoxy)-2-quinolinone 2(1H)-Quinolinone, 5,5'-[[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)imino]bis(1-hydroxy-2,1-ethanediyl)]bis[8-(phenylmethoxy)- (S)-Indacaterol Indacaterol Impurity 12 5-ForMyl-8-hydroxycarbostyril N-benzyl-5,6-diethyl-2,3-dihydro-1H-inden-2-amine 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)(phenylmethyl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)- 2,8-Quinolinediol 2(1H)-Quinolinone, 5-[(1S)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)- 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Indacaterol interMediate Indacaterol Impurity 13 (Mixture of Diastereomers) 2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2R)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, rel- (S)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one Indacaterol Impurity 19 2-Aminoindan hydrochloride

8-Benzyloxy-5

1-[8-(benzyloxy)-2-hydroxyquinolin-5-yl]-2-broMoethan-1-one

8-(benzyloxy)-5-(2-broMoacetyl)quinolin-2(1H)-one

5-(2-BroMo-1-oxoethyl)-8-benzyloxy-2(1H)-quinolinone

5-(BroMoacetyl)-8-(phenylMethoxy)-2(1H)-quinolinone

5-BroMoacetyl-8-benzyloxycarbostyril

8-Benzyloxy-5-(2-broMoacetyl)-2-(1h)-quinoline

8-benzyloxy-5-(2-broMoacetyl)-2-(1H)-quinolinone

2(1H)-Quinolinone, 5-(2-bromoacetyl)-8-(phenylmethoxy)-

Indacaterol Intermediate 2

8-(Benzyloxy)-5-(broMoacetyl)quinolin-2(1H)-one

1-[8-(b

Indacaterol int

Adatero and its intermediates

5-(2-Bromoacetyl)-8-benzyloxy-1H-quinolin-2-one

5-(2-bromoacetyl)-8-phenylmethoxy-1H-quinolin-2-one

Indacaterol Impurity 37

5-(2-Bromoacetyl)-8-(phenylmethoxy)-2(1H)-quinolinone

8-BENZYLOXY-5-(2-BROMOACETYL)-2-HYDROXYQUINOLINE

Intermediate of 8-benzyloxy-5-bromoacetyl-2-quinolinone indaterol

5-Bromoacetyl-8-benzyloxy-2-quinolone

8-Benzyloxyl-5-(2-bromoacetyl)-2-hydroxyquinoline

100331-89-3

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Intermediate of Indacaterol