5-Acetyl-8-(phenylmethoxy)-2-quinolinone

Product Name: 5-Acetyl-8-(phenylmethoxy)-2-quinolinone
CAS No.: 93609-84-8
Chemical Name: 5-Acetyl-8-(phenylmethoxy)-2-quinolinone
Synonyms: Indacaterol int1;Indacaterol Impurity 6;CarMoterol interMediate;Indacaterol Impurity 32;Indacaterol Impurity 39;5-Acetyl-8-benzyloxy-2-quinolone;5-Acetyl-8-(benzyloxy)carbostyril;5-Acetyl-8-benzyloxy-2(1H)-quinolinone;5-Acetyl-8-benzyloxy-1H-quinolin-2-one;5-Acetyl-8-benzyloxy-1H-quinoline-2-one
CBNumber: CB62534817
Molecular Formula: C18H15NO3
Formula Weight: 293.32
MOL File: 93609-84-8.mol

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5-Acetyl-8-(phenylmethoxy)-2-quinolinone Property

Melting point:: 174-176℃
Density: 1.230
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
color: Light Orange
InChI: InChI=1S/C18H15NO3/c1-12(20)14-7-9-16(18-15(14)8-10-17(21)19-18)22-11-13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,19,21)
InChIKey: MVYPGJMOODJFAZ-UHFFFAOYSA-N
SMILES: N1C2=C(C(C(C)=O)=CC=C2OCC2=CC=CC=C2)C=CC1=O

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Safety

HS Code: 2914390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: KOB0028
Product name: 5-Acetyl-8-(benzyloxy)-1,2-dihydroquinolin-2-one
Packaging: 1G
Price: $259
Updated: 2025/07/31

TRC

Product number: A187530
Product name: 5-Acetyl-8-(phenylmethoxy)-2-quinolinone
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17096
Product name: 5-Acetyl-8-(phenylmethoxy)-2-quinolinone
Packaging: 2mg
Price: $120
Updated: 2021/12/16

Apolloscientific

Product number: OR61366
Product name: 5-Acetyl-8-(benzyloxy)quinolin-2(1H)-one
Packaging: 500mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: 5896AC
Product name: 5-Acetyl-8-(benzyloxy)quinolin-2(1H)-one
Packaging: 5g
Price: $172
Updated: 2021/12/16

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5-Acetyl-8-(phenylmethoxy)-2-quinolinone Chemical Properties,Usage,Production

Chemical Properties

White or off-white solid powder

Uses

5-Acetyl-8-(phenylmethoxy)-2-quinolinone can be used in the preparation of phenylethanolamine derivatives as β2 adrenoreceptor agonists.

Synthesis

100-39-0

62978-73-8

93609-84-8

The general procedure for the synthesis of 5-acetyl-8-benzyloxy-1H-quinolin-2-one from 5-acetyl-8-hydroxyquinolin-2(1H)-one (8.13 g, 40 mmol, 1.0 eq.) and benzyl bromide (7.52 g, 44 mmol, 1.10 eq.) was as follows: crude 5-acetyl-8-hydroxyquinolin-2(1H)-one was added to acetone (64 mL) containing N ,N-diisopropylethylamine (6.46 g, 50 mmol, 1.25 equiv) in acetone (64 mL). After heating the suspension to reflux temperature, water (8.2 mL) was added. Benzyl bromide was slowly added dropwise and the reaction mixture was kept at reflux temperature for 6-7 hours until the feedstock was completely consumed. Upon completion of the reaction, water (20 mL) was added at 58°C and the mixture was cooled to 20-25°C. The product was collected by filtration and washed sequentially with acetone/water (1:1, 2 x 8.5 mL) and water (4 x 8 mL). The crude product was dried under vacuum at 60 °C overnight to give 10.77 g (91.7% yield) of 5-acetyl-8-benzyloxy-1H-quinolin-2-one with 99.5% purity of the crude product. The product can be further purified by recrystallization from acetone/water system.

References

[1] Patent: WO2004/87668, 2004, A1. Location in patent: Page 29
[2] Patent: WO2005/123684, 2005, A2. Location in patent: Page/Page column 34
[3] Patent: US2004/224982, 2004, A1. Location in patent: Page 10
[4] Patent: US2004/242622, 2004, A1. Location in patent: Page 29
[5] Patent: US2004/167167, 2004, A1. Location in patent: Page/Page column 32

5-Acetyl-8-(phenylmethoxy)-2-quinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Acetyl-8-(phenylmethoxy)-2-quinolinone Suppliers

Canada 1 China 98 India 3 United Kingdom 3 United States 7 Global 112

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View Lastest Price from 5-Acetyl-8-(phenylmethoxy)-2-quinolinone manufacturers

Career Henan Chemical Co

Product: 5-Acetyl-8-(phenylmethoxy)-2-quinolinone 93609-84-8
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

93609-84-8, 5-Acetyl-8-(phenylmethoxy)-2-quinolinoneRelated Search:

INDENO(1,2,3-C,D)PYRENE 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline N-benzyl-5,6-diethyl-2,3-dihydro-1H-inden-2-amine 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)(phenylmethyl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)- Indacaterol interMediate 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride 2(1H)-Quinolinone, 5-[(1S)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)- 2(1H)-Quinolinone, 5,5'-[[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)imino]bis(1-hydroxy-2,1-ethanediyl)]bis[8-(phenylmethoxy)- (S)-Indacaterol Indacaterol Impurity 12 5-ForMyl-8-hydroxycarbostyril 8-HYDROXY-QUINOLINE-5-CARBALDEHYDE 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone Indacaterol Impurity 34 2-Aminoindan hydrochloride 5-ACETYL-8-HYDROXY-1H-QUINOLIN-2-ONE 2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2R)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, rel- Indacaterol Impurity 13 (Mixture of Diastereomers)

5-Acetyl-8-(benzyloxy)quinolin-2(1H)-one

CarMoterol interMediate

5-Acetyl-8-(benzyloxy)carbostyril

5-Acetyl-8-benzyloxy-1H-quinolin-2-one

5-Acetyl-8-benzyloxy-2(1H)-quinolinone

5-Acetyl-8-(benzyloxy)-1,2-dihydroquinolin-2-one

8-(Benzyloxy)-5-(1-oxoethyl)-1H-quinolin-2-one

5-Acetyl-8-(phenylMethoxy)-2-quinolinone

2(1H)-Quinolinone, 5-acetyl-8-(phenylmethoxy)-

5-acetyl-8-phenylmethoxy-1H-quinolin-2-one

5-Acetyl-8-(benzyloxy)-1,2-dihydro-2-oxoquinoline, 1-[8-(Benzyloxy)-1,2-dihydro-2-oxoquinolin-5-yl]ethan-1-one

Indacaterol Impurity 6

Indacaterol int1

Indacaterol Impurity 32

5-Acetyl-8-(phenylmethoxy)-2-quinolinone ISO 9001：2015 REACH

Indacaterol Impurity 39

5-Acetyl-8-benzyloxy-1H-quinoline-2-one

5-Acetyl-8-benzyloxy-2-quinolone

5-Acetyl-8-benzyloxyl-1H-quinolin-2-one/indole

93609-84-8

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