D-PYROGLUTAMIC ACID TERT-BUTYL ESTER

Product Name: D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
CAS No.: 205524-46-5
Chemical Name: D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
Synonyms: idone-5-carboxyL;Glutamic Acid Impurity 21;tert-butyl D-Pyroglutamate;tert-butyl 5-oxo-D-prolinate;5-Oxo-D-proline tert-butyl ester;D-PyroglutaMic acid ter-butyl ester;2-Methyl-2-propanyl 5-oxo-D-prolinate;D-PYROGLUTAMIC ACID TERT-BUTYL ESTER;5-oxo-D-Proline1,1-dimethylethyl ester;tert-Butyl (R)-2-Pyrrolidone-5-carboxylate
CBNumber: CB51119313
Molecular Formula: C9H15NO3
Formula Weight: 185.22
MOL File: 205524-46-5.mol

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D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Property

Boiling point:: 319℃
Density: 1.099
Flash point:: 147℃
storage temp.: 2-8°C
pka: 14.65±0.40(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure
InChI: InChI=1S/C9H15NO3/c1-9(2,3)13-8(12)6-4-5-7(11)10-6/h6H,4-5H2,1-3H3,(H,10,11)/t6-/m1/s1
InChIKey: QXGSPAGZWRTTOT-ZCFIWIBFSA-N
SMILES: C(OC(C)(C)C)(=O)[C@H]1CCC(=O)N1

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Safety

HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 287633
Product name: D-Pyroglutamic acid tert-butyl ester
Packaging: 1g
Price: $425
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-1-R1
Product name: tert-Butyl (2R)-5-oxopyrrolidine-2-carboxylate
Packaging: 25g
Price: $576
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0004827
Product name: D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $780.78
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0004827
Product name: D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 5G
Price: $942
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0004827
Product name: D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 10G
Price: $1264
Updated: 2021/12/16

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D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

540-88-5

4042-36-8

205524-46-5

The general procedure for the synthesis of tert-butyl D-pyroglutamate from tert-butyl acetate and D-(+)-pyroglutamic acid was as follows: (R)-5-oxopyrrolidine-2-carboxylic acid (3.21 g, 24.9 mmol) was dissolved in tert-butyl acetate (100 mL) under argon protection. Subsequently, 60% aqueous perchloric acid (1.5 mL) was slowly added at room temperature. The reaction mixture was stirred at room temperature for 24 hours in an argon atmosphere. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution (50 mL) was added to the mixture to neutralize the reaction solution, followed by extraction with chloroform (3 x 30 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and the solvent was removed by distillation under reduced pressure to afford tert-butyl (R)-5-oxopyrrolidine-2-carboxylate (4.62 g, yield) as a white solid. The physical properties of the product are described below.

References

[1] Chemistry - A European Journal, 2016, vol. 22, # 27, p. 9330 - 9337
[2] Patent: JP6095208, 2017, B2. Location in patent: Paragraph 0036-0038

D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Suppliers

China 99 India 1 United Kingdom 1 United States 11 Global 112

Pure Chemistry Scientific Inc.

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View Lastest Price from D-PYROGLUTAMIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: D-PYROGLUTAMIC ACID TERT-BUTYL ESTER 205524-46-5
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-26

205524-46-5, D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Related Search:

D-Pyroglutamic acid H-D-PRO-OTBU 5-OXO-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER Ethyl D-(-)-pyroglutamate D-PYROGLUTAMIC ACID TERT-BUTYL ESTER

D-PYROGLUTAMIC ACID TERT-BUTYL ESTER

(R)-5-Oxo-pyrrolidine-2-carboxylic acid tert-butyl ester

5-Oxo-D-proline tert-butyl ester

tert-butyl 5-oxo-D-prolinate

D-PyroglutaMic acid ter-butyl ester

tert-Butyl (R)-2-Pyrrolidone-5-carboxylate

2-Methyl-2-propanyl 5-oxo-D-prolinate

tert-butyl (2R)-5-oxopyrrolidine-2-carboxylate

(R)-tert-Butyl 5-oxopyrrolidine-2-carboxylate

5-oxo-D-Proline1,1-dimethylethyl ester

idone-5-carboxyL

D-Proline, 5-oxo-, 1,1-dimethylethyl ester

ert-butyl(2R)-5-oxopyrrolidine-2-carboxylate

D-PYROGLUTAMIC ACID TERT-BUTYL ESTER USP/EP/BP

tert-butyl D-Pyroglutamate

Glutamic Acid Impurity 21

205524-46-5