Thalidomide-NH-C3-NH-Boc

Product Name: Thalidomide-NH-C3-NH-Boc
CAS No.: 2093386-36-6
Chemical Name: Thalidomide-NH-C3-NH-Boc
Synonyms: Thalidomide-NH-C3-NH-Boc;Thalidomide-4-NH-C3-NH-Boc;Thalidomide-NH-(CH2)3-NH-Boc;tert-Butyl [3-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]amino]ethyl]carbamate;Carbamic acid, N-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propyl]-, 1,1-dimethylethyl ester
CBNumber: CB511313143
Molecular Formula: C21H26N4O6
Formula Weight: 430.45
MOL File: 2093386-36-6.mol

More

Less

Thalidomide-NH-C3-NH-Boc Property

Boiling point:: 695.8±55.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
pka: 10.75±0.40(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

Thalidomide-NH-C3-NH-Boc Chemical Properties,Usage,Production

Uses

Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)3-NH-Boc is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules targeting 11β-substituted estradiol.

IC 50

Cereblon

References

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527

Thalidomide-NH-C3-NH-Boc Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Thalidomide-NH-C3-NH-Boc Suppliers

China 14 Global 14

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 8645
Advantage: 58

Zhengzhou Convergence Chemical Co. LTD

Tel: 0371-0371-53736046 13393710386
Fax: QQ:2853979814
Email: 2853979814@qq.com
Country: China
ProdList: 9947
Advantage: 58

Xi'an Qiyue Biotechnology Co., Ltd.

Tel: 400-400-6966-012-012 17778955912
Email: 2957605606@qq.com
Country: China
ProdList: 2535
Advantage: 58

Chengdu Yuxin Technology Co., Ltd.

Tel: 13558691827
Email: yuxinpharma@126.com
Country: China
ProdList: 95
Advantage: 58

Shanghai Hongboshangyi Pharmaceutical Technology Co. , Ltd.

Tel: 15927323052
Email: shenqianyan@prssh.com
Country: China
ProdList: 999
Advantage: 58

Suzhou Haiben Pharmaceutical Co., Ltd

Tel: 19353112242
Email: 1816280386@qq.com
Country: China
ProdList: 8045
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: 18143011203
Email: ET-market@chemextension.com
Country: China
ProdList: 32035
Advantage: 58

Hubei Ruinuo Pharmaceutical Technology Co., Ltd

Tel: 0714-5316360; 13165688766
Fax: 0714-5316360
Email: 3008058303@qq.com
Country: China
ProdList: 3000
Advantage: 58

More

Less

View Lastest Price from Thalidomide-NH-C3-NH-Boc manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Thalidomide-NH-C3-NH-Boc 2093386-36-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-08

2093386-36-6, Thalidomide-NH-C3-NH-BocRelated Search:

tert-butyl (8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)carbamate Thalidomide-NH-PEG1-NH-Boc N-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-carbamic Acid 1,1-Dimethylethyl Ester Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester N-[2-Aminoethyl] Pomalidomide Trifluoroacetic Acid Salt Carbamic acid, N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-, 1,1-dimethylethyl ester

Thalidomide-NH-C3-NH-Boc

Thalidomide-NH-(CH2)3-NH-Boc

Carbamic acid, N-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propyl]-, 1,1-dimethylethyl ester

Thalidomide-4-NH-C3-NH-Boc

tert-Butyl [3-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]amino]ethyl]carbamate

2093386-36-6