Cerivastatin sodium
- Product Name
- Cerivastatin sodium
- CAS No.
- 143201-11-0
- Chemical Name
- Cerivastatin sodium
- Synonyms
- BAYCOL;BAY-w 6228;Rivastatin hydrate;Cerivastatin sodium;Rivastatin, Baycol, Lipobay;Cerivastatin-13C-d3 Sodium Salt;Cerivastatin sodium salt hydrate;Sodium 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyrid in-3-yl]-3,5-dihydroxy-hept-6-enoate;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(MethoxyMethyl)-2,6-bis(1-Methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic Acid SodiuM Salt;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate
- CBNumber
- CB5115264
- Molecular Formula
- C26H35FNNaO5
- Formula Weight
- 483.56
- MOL File
- 143201-11-0.mol
Cerivastatin sodium Property
- Melting point:
- 197-199°C
- alpha
- D20 +24.1° (c = 1 in ethanol)
- storage temp.
- Hygroscopic, Store under Inert atmosphere -20°C Freezer
- solubility
- H2O: ≥5mg/mL
- form
- powder
- color
- white to tan
- optical activity
- [α]/D +18 to +26° in ethanol
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 143201-11-0(CAS DataBase Reference)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0005
- Product name
- Cerivastatin sodium salt hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- SML0005
- Product name
- Cerivastatin sodium salt hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $646
- Updated
- 2024/03/01
- Product number
- 20362
- Product name
- Cerivastatin (sodium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 20362
- Product name
- Cerivastatin (sodium salt)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $207
- Updated
- 2024/03/01
- Product number
- 20362
- Product name
- Cerivastatin (sodium salt)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $479
- Updated
- 2024/03/01
Cerivastatin sodium Chemical Properties,Usage,Production
Description
Lipobay was launched in Denmark, Germany and the UK for treatment of primary hypercholesteremia types Ⅱa and Ⅱb. It is available through a nine step synthesis beginning with the Hantsch reaction of ethyl 3-amino-4-methylpent-2-enoate and 4-(ethoxycarbonyl)-5-(4-fluorophenyl)-2-methylpent-4-en-3-one. Lipobay acts as an HMG-CoA reductase inhibitor showing a high liver selectivity (50 fold). In vitro Lipobay had a higher affinity (110x) for the enzyme than does Lovastatin, Simvastatin and pravastatin which resulted in a lower ED50, in vivo compared to Lovastatin. Three metabolites generated by the CYP3A4 enzyme system were equal to the parent in activity. Lipobay was as effective as Gemfibrozil in type lib hypercholesteremia and had no age or gender effects. It decreased plasma levels of VLDL and LDL cholesterol by a mechanism similar to other HMG-CoA reductase inhibitors. The (-)- antipode is completely inactive indicating a high stereospecificity by the enzyme. It is therapeutically useful at ultra-low doses which may minimize any drug-drug interactions.
Chemical Properties
Solid
Originator
Bayer (Germany)
Uses
Cerivastatin is a competitive inhibitor of HMG-CoA reductase.
Uses
Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.
Definition
ChEBI: The sodium salt of cerivastatin. Formerly used to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.
brand name
Baycol (Bayer).
General Description
Cerivastatin sodium salt hydrate belongs to the statin class of lipid lowering agents. It helps in decreasing MAP kinase activation, blocking AP-1 (activator protein-1) and NF-kB (nuclear factor-kB ) binding activity, inhibiting inflammatory responses and ameliorated renal damage. It also lowers cholesterol. It is metabolized by cytochrome P450 (CYP)3A4 and (CYP)2C8. Cerivastatin sodium salt hydrate is linked to rhabdomyolysis.
Hazard
A poison by ingestion.
Biochem/physiol Actions
Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.
Cerivastatin sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cerivastatin sodium manufacturers
- Product
- Cerivastatin sodium 143201-11-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-11