2,5-Dibromotoluene
- Product Name
- 2,5-Dibromotoluene
- CAS No.
- 615-59-8
- Chemical Name
- 2,5-Dibromotoluene
- Synonyms
- 2,5-dibromotuluene;2,5-DIBROMOTOLUENE;Toluene,2,5-dibromo-;Toluene, 2,5-dibromo-;2,5-Dibromotoluene>2,5-Dibromotoluene,99%;2,5-Dibromotoluene 97%;2,5-Dibromotoluene,97%;f,5-DIBROMOTOLUENE, 98%;2,5-Dibromotoluene ,98%
- CBNumber
- CB5115976
- Molecular Formula
- C7H6Br2
- Formula Weight
- 249.93
- MOL File
- 615-59-8.mol
2,5-Dibromotoluene Property
- Melting point:
- 5-6 °C (lit.)
- Boiling point:
- 135-136 °C/35 mmHg (lit.)
- Density
- 1.815 g/mL at 25 °C (lit.)
- refractive index
- 1.601-1.603
- Flash point:
- 110°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- form
- Liquid
- Specific Gravity
- 1.815
- color
- Clear colorless to yellow
- BRN
- 1859123
- CAS DataBase Reference
- 615-59-8(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 1,4-dibromo-2-methyl-(615-59-8)
- EPA Substance Registry System
- 2,5-Dibromotoluene (615-59-8)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-37/39-26
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 250988
- Product name
- 2,5-Dibromotoluene
- Purity
- 98%
- Packaging
- 5g
- Price
- $52.6
- Updated
- 2025/07/31
- Product number
- 250988
- Product name
- 2,5-Dibromotoluene
- Purity
- 98%
- Packaging
- 25g
- Price
- $67.6
- Updated
- 2025/07/31
- Product number
- D2577
- Product name
- 2,5-Dibromotoluene
- Packaging
- 5G
- Price
- $25
- Updated
- 2025/07/31
- Product number
- D425883
- Product name
- 1,4-Dibromo-2-methylbenzene
- Packaging
- 25g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- JK120183
- Product name
- 2,5-Dibromotoluene
- Purity
- 98%
- Packaging
- 5g
- Price
- $31
- Updated
- 2021/12/16
2,5-Dibromotoluene Chemical Properties,Usage,Production
Chemical Properties
clear colourless to yellowish liquid
Uses
2,5-Dibromotoluene has been used:
- as internal standard for quantification of cyanide and thiocyanate in human saliva by GC-MS
- in the preparation of 2,5-bis(4′-alkoxycarbonylphenyl)styrenes, monomers required for the synthesis of mesogen-jacketed liquid-crystal polymers
Synthesis
583-75-5
615-59-8
The general procedure for the synthesis of 2,5-dibromotoluene from 2-methyl-4-bromoaniline is as follows: 400 mL of 23% aqueous hydrobromic acid was added to a 2000 mL three-necked beaker, and 46.5 g (0.25 mol) of pre-melted 2-methyl-4-bromoaniline was slowly added. A mechanical stirrer was turned on and the reaction mixture was stirred continuously for 20 minutes and subsequently cooled to -50°C. This temperature was maintained and a solution of 22.4 g (0.33 mol) of sodium nitrite dissolved in 130 mL of water was added slowly and dropwise through a constant pressure dropping funnel over a period of 1 hour. Upon completion of the reaction, the resulting diazonium salt solution was added in batches to 100 mL of 47% hydrobromic acid solution containing 35.9 g (0.25 mol) of copper bromide at 0°C. The reaction system was gradually warmed to 70 °C and stirred at this temperature for 30 min. At the end of the reaction, it was cooled to room temperature and extracted with methyl tert-butyl ether (3 x 200 mL). The organic phases were combined, dried with anhydrous potassium carbonate and concentrated under reduced pressure to remove the solvent. The crude product was first initially purified by passing through a short silica gel column (silica gel 60, 40-63 μm, column diameter 60 mm, height 140 mm; eluent: n-hexane). Finally, the colorless oily product with a boiling point of 100-102 °C/10 mmHg was collected by decompression distillation in a yield of 36.1 g (58% yield). Calculated elemental analysis (C7H6Br2): C, 33.64; H, 2.42. Measured values: C, 33.79; H, 2.50.1H NMR (CDCl3, 400 MHz) δ: 7.39 (m, 1H, Ar-H), 7.37 (m, 1H, Ar-H), 7.18 (m, 1H, Ar-H), 2.38 (s, 3H, -CH3).13C NMR (CDCl3, 400 MHz) δ: 7.39 (m, 1H, Ar-H), 7.37 (m, 1H, Ar-H), 7.18 (m, 1H, Ar-H), 2.38 (s, 3H, -CH3). -CH3).13C NMR (CDCl3, 100 MHz) δ: 139.9, 133.6, 133.5, 130.3, 123.5, 120.9, 22.7.
References
[1] Patent: WO2007/70041, 2007, A1. Location in patent: Page/Page column 109-110
[2] Justus Liebigs Annalen der Chemie, 1873, vol. 168, p. 153
[3] Justus Liebigs Annalen der Chemie, 1878, vol. 192, p. 202
[4] Chemische Berichte, 1880, vol. 13, p. 963
[5] Chemische Berichte, 1881, vol. 14, p. 417
2,5-Dibromotoluene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Dibromotoluene manufacturers
- Product
- 2,5-Dibromotoluene 615-59-8
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 1,4-Dibromo-2-methylbenzene 615-59-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0%
- Supply Ability
- 100 tons
- Release date
- 2022-02-20
- Product
- 2,5-Dibromotoluene 615-59-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-31