BQ-3020
- Product Name
- BQ-3020
- CAS No.
- 143113-45-5
- Chemical Name
- BQ-3020
- Synonyms
- BQ-3020;BQ-3020 TFA salt;AC-LMDKEAVYFAHLDIIW;M.W. 2006.35 C96H140N20O25S;Acetyl-(Ala 11,15)-ET 1 (6-21);endothelin receptor antagonist;AC-(ALA11,15)-ENDOTHELIN-1 (6-21);N-AC, ALA11,15-ENDOTHELIN 1, 6-21;ACETYL-(ALA11,15)-ENDOTHELIN-1 (6-21);ACETYL-(D-TRP16)-ENDOTHELIN-1 (16-21)
- CBNumber
- CB5117455
- Molecular Formula
- C96H140N20O25S
- Formula Weight
- 2006.34
- MOL File
- 143113-45-5.mol
BQ-3020 Property
- Boiling point:
- 2125.8±65.0 °C(Predicted)
- Density
- 1.287±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M)
- pka
- 3.39±0.10(Predicted)
- form
- powder
- color
- white
- Sensitive
- Light Sensitive
- Sequence
- Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SCP0138
- Product name
- BQ-3020
- Packaging
- 500μg
- Price
- $284
- Updated
- 2025/07/31
- Product number
- SCP0138
- Product name
- BQ-3020
- Purity
- ≥97% (HPLC)
- Packaging
- 1mg
- Price
- $405
- Updated
- 2025/07/31
- Product number
- 1189
- Product name
- BQ-3020
- Packaging
- 500U
- Price
- $249
- Updated
- 2021/12/16
- Product number
- B703153
- Product name
- BQ-3020
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B703153
- Product name
- BQ-3020
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
BQ-3020 Chemical Properties,Usage,Production
Uses
BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.
Biological Activity
BQ-3020, a linear endothelin analog, is a selective ETB endothelin receptor agonist.
in vivo
BQ-3020 (3 mg/kg for i.h., single dose) attenuates cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection in cancer pain mouse model[3].
| Animal Model: | Cancer pain mouse model [3] |
| Dosage: | 3 mg/kg |
| Administration: | Injected subcutaneously at the site of the greatest tumor development |
| Result: | Attenuated cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection |
IC 50
ETB: 0.2 nM (IC50)
storage
-20°C
References
[1] Arteaga JL,et.al. Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck. Neurourol Urodyn. 2012 Jun;31(5):688-94. DOI:10.1002/nau.22203
[2] Ihara M, et.al. A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors. Life Sci. 1992;51(6):PL47-52. DOI:10.1016/0024-3205(92)90418-o
[3] Quang PN, et.al. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain. 2010 May;149(2):254-262. DOI:10.1016/j.pain.2010.02.009
BQ-3020 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BQ-3020 manufacturers
- Product
- BQ-3020 143113-45-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13