ChemicalBook > CAS DataBase List > BQ-3020

BQ-3020

Product Name
BQ-3020
CAS No.
143113-45-5
Chemical Name
BQ-3020
Synonyms
BQ-3020;BQ-3020 TFA salt;AC-LMDKEAVYFAHLDIIW;M.W. 2006.35 C96H140N20O25S;Acetyl-(Ala 11,15)-ET 1 (6-21);endothelin receptor antagonist;AC-(ALA11,15)-ENDOTHELIN-1 (6-21);N-AC, ALA11,15-ENDOTHELIN 1, 6-21;ACETYL-(ALA11,15)-ENDOTHELIN-1 (6-21);ACETYL-(D-TRP16)-ENDOTHELIN-1 (16-21)
CBNumber
CB5117455
Molecular Formula
C96H140N20O25S
Formula Weight
2006.34
MOL File
143113-45-5.mol
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BQ-3020 Property

Boiling point:
2125.8±65.0 °C(Predicted)
Density 
1.287±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M)
pka
3.39±0.10(Predicted)
form 
powder
color 
white
Sensitive 
Light Sensitive
Sequence
Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SCP0138
Product name
BQ-3020
Packaging
500μg
Price
$284
Updated
2025/07/31
Sigma-Aldrich
Product number
SCP0138
Product name
BQ-3020
Purity
≥97% (HPLC)
Packaging
1mg
Price
$405
Updated
2025/07/31
Tocris
Product number
1189
Product name
BQ-3020
Packaging
500U
Price
$249
Updated
2021/12/16
TRC
Product number
B703153
Product name
BQ-3020
Packaging
5mg
Price
$45
Updated
2021/12/16
TRC
Product number
B703153
Product name
BQ-3020
Packaging
10mg
Price
$60
Updated
2021/12/16
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BQ-3020 Chemical Properties,Usage,Production

Uses

BQ-3020 is a selective endothelin receptor (ETB receptor) agonist that displaces [125I] ET-1 binding to ETB receptors, with an IC50 value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research12.

Biological Activity

BQ-3020, a linear endothelin analog, is a selective ETB endothelin receptor agonist.

in vivo

BQ-3020 (3 mg/kg for i.h., single dose) attenuates cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection in cancer pain mouse model[3].

Animal Model:Cancer pain mouse model [3]
Dosage:3 mg/kg
Administration:Injected subcutaneously at the site of the greatest tumor development
Result:Attenuated cancer pain by approximately 50% up to 3 h post-injection compared to PBS-vehicle and contralateral injection

IC 50

ETB: 0.2 nM (IC50)

storage

-20°C

References

[1] Arteaga JL,et.al. Endothelin ET(B) receptors are involved in the relaxation to the pig urinary bladder neck. Neurourol Urodyn. 2012 Jun;31(5):688-94. DOI:10.1002/nau.22203
[2] Ihara M, et.al. A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors. Life Sci. 1992;51(6):PL47-52. DOI:10.1016/0024-3205(92)90418-o
[3] Quang PN, et.al. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain. 2010 May;149(2):254-262. DOI:10.1016/j.pain.2010.02.009

BQ-3020 Preparation Products And Raw materials

Raw materials

Preparation Products

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China 83 France 1 Germany 2 Switzerland 2 United Kingdom 3 United States 8 USA 1 Global 100
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View Lastest Price from BQ-3020 manufacturers

Career Henan Chemical Co
Product
BQ-3020 143113-45-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-13

143113-45-5, BQ-3020Related Search:

([125I]-TYR)-ENDOTHELIN-1 (HUMAN, BOVINE, DOG, MOUSE, PORCINE, RAT) BQ-3020 Endothelin-1 (human, porcine) ENDOTHELIN-1 [ALA1,3,11,15] [3-(125I)TYR] (HUMAN) H-ALA-SER-ALA-SER-SER-LEU-MET-ASP-LYS-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP-OH

  • N-AC, ALA11,15-ENDOTHELIN 1, 6-21
  • N-ACETYL[ALA11,15]-ENDOTHELIN-1 (6-21)
  • N-ACETYL-[ALA11,15]ENDOTHELIN-I (6-21)
  • AC-(ALA11,15)-ENDOTHELIN-1 (6-21)
  • BQ-3020
  • ENDOTHELIN-1(6-21), N-ACETYL-[ALA11,15]-
  • Acetyl-(Ala11·15)-Endothelin-1 (6-21) Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
  • ACETYL-(ALA11,15)-ENDOTHELIN-1 (6-21)
  • ACETYL-LEU-MET-ASP-LYS-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP-OH
  • AC-LEU-MET-ASP-LYS-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP
  • AC-LEU-MET-ASP-LYS-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP-OH
  • AC-LMDKEAVYFAHLDIIW
  • BQ-3020 ENDOTHELIN-1(6-21),N-ACETYL-(ALA 11, 15) SYNTHETIC >97%
  • n-acetyl-[ala11,15]-endothelin 1 fragment 6-21
  • ACETYL-(D-TRP16)-ENDOTHELIN-1 (16-21)
  • Acetyl-(Ala 11,15)-ET 1 (6-21)
  • endothelin receptor antagonist
  • M.W. 2006.35 C96H140N20O25S
  • Acetyl-(Ala11·15)-Endothelin-1 (6-21) BQ-3020
  • 6-21-Endothelin 1 (swine reduced), N-acetyl-11-L-alanine-15-L-alanine-
  • BQ 3020 /Ac-[Ala11,15]-Endothelin 1 (6-21)
  • Acetyl-(Ala??·??)-Endothelin-1 (6-21) ammonium salt
  • Acetyl-(Ala11·1?)-Endothelin-1 (6-21)
  • BQ-3020 TFA salt
  • Acetyl-(Ala11.15)-Endothelin-1 (6-21) ammonium salt
  • 143113-45-5
  • C96H140N20O25S
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • BioChemical
  • Agonist
  • Peptides
  • Endothelins
  • Endothelin receptor