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N-(n-Nonyl)deoxynojirimycin

Product Name
N-(n-Nonyl)deoxynojirimycin
CAS No.
81117-35-3
Chemical Name
N-(n-Nonyl)deoxynojirimycin
Synonyms
Nonyl-DNJ;N-Nonyldeoxynojirimycin;N-(n-Nonyl)-1-deoxynojirimycin;N-(n-Nonyl)-1-deoxynojirimycin min. 99%;(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol;(2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol;3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-nonyl-, (2R,3R,4R,5S)-
CBNumber
CB51176507
Molecular Formula
C15H31NO4
Formula Weight
289.41
MOL File
81117-35-3.mol
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N-(n-Nonyl)deoxynojirimycin Property

Melting point:
101-102°C
Boiling point:
451.7±45.0 °C(Predicted)
Density 
1.112±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: >10mg/mL
form 
solid
pka
13.72±0.70(Predicted)
color 
White to off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N6414
Product name
NN-DNJ
Purity
≥98% (HPLC)
Packaging
5mg
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
N6414
Product name
NN-DNJ
Purity
≥98% (HPLC)
Packaging
25mg
Price
$880
Updated
2024/03/01
Cayman Chemical
Product number
29698
Product name
N-Nonyldeoxynojirimycin
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
29698
Product name
N-Nonyldeoxynojirimycin
Packaging
25mg
Price
$469
Updated
2024/03/01
Cayman Chemical
Product number
29698
Product name
N-Nonyldeoxynojirimycin
Packaging
5mg
Price
$155
Updated
2024/03/01
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N-(n-Nonyl)deoxynojirimycin Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Definition

ChEBI: N-nonyldeoxynojirimycin is a hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group. It has a role as an EC 3.2.1.45 (glucosylceramidase) inhibitor, an EC 3.2.1.20 (alpha-glucosidase) inhibitor and an antiviral agent. It is a hydroxypiperidine and a tertiary amino compound. It is functionally related to a duvoglustat.

Biological Activity

Glucosidase inhibitor (IC 50 values are 0.42 and 8.4 μ M for acid α -glucosidase and α -1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo . Also acts as a chemical chaperone; chaperones β -Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.

Biochem/physiol Actions

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

storage

Store at -20°C

N-(n-Nonyl)deoxynojirimycin Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(n-Nonyl)deoxynojirimycin Suppliers

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81117-35-3, N-(n-Nonyl)deoxynojirimycinRelated Search:


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  • (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol
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