Nitecapone

Description In vitro Biological activity

Product Name: Nitecapone
CAS No.: 116313-94-1
Chemical Name: Nitecapone
Synonyms: OR 462;Nitecapone;Nitecapone, 10 mM in DMSO;3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione;3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione;3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione;2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-;GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia
CBNumber: CB51176592
Molecular Formula: C12H11NO6
Formula Weight: 265.22
MOL File: 116313-94-1.mol

More

Less

Nitecapone Property

Melting point:: 171-173°C
Boiling point:: 495.3±45.0 °C(Predicted)
Density: 1.451±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: soluble15mg/mL, clear
pka: 5.60±0.50(Predicted)
form: powder
color: white to beige

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Toxicity: mouse,LD50,intraperitoneal,507mg/kg (507mg/kg),Pharmacology and Toxicology Vol. 69, Pg. 64, 1991.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0671
Product name: Nitecapone
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $73.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0671
Product name: Nitecapone
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $354
Updated: 2024/03/01

Cayman Chemical

Product number: 18656
Product name: Nitecapone
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 18656
Product name: Nitecapone
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 18656
Product name: Nitecapone
Purity: ≥98%
Packaging: 25mg
Price: $288
Updated: 2024/03/01

More

Less

Nitecapone Chemical Properties,Usage,Production

Description

Nitecapone (OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).It was patented as an antiparkinson medication.

In vitro

Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biological activity

Nitecapone (OR-462) is a short-acting, orally active, catechol-O-methyltransferase (COMT) inhibitor with gastrointestinal protective and antioxidant activity. Nitecapone (OR-462) scavenges reactive oxygen species and nitric oxide and prevents lipid peroxidation.

Chemical Properties

Yellow Solid

Uses

Inhibitor for the treatment of Parkinson disease

Uses

Inhibitor for the treatment of Parkinson's disease.

Definition

ChEBI: Nitecapone is a hydroxycinnamic acid.

Biological Activity

Nitecapone is a short-acting inhibitor of catechol-O-methyltransferase (COMT). Nitecapone displays in vivo activity in peripheral tissues, but does not pentrate the blood brain barrier. The compound increases mechanical and thermal nociception, and reduces neuropathic pain in diabetic rats and in a spinal nerve ligation model.

Nitecapone Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Nitecapone Suppliers

Canada 1 China 47 India 2 United States 9 USA 1 Global 60

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 2000
Advantage: 58

ShangHai Wisacheam Pharmaceutical Co., Ltd.

Tel: 13817485796
Fax: QQ:895624079
Email: tim@wisacheampharm.com
Country: China
ProdList: 3833
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: 021-51619050 13301662590
Fax: +86-21-51619052
Email: mandy@atkchemical.com
Country: China
ProdList: 10197
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7312
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beyond Pharmaceutical Co., Ltd

Tel: +86-0571-81953185; 15381198709 15381198709
Fax: 0571-89086206
Email: jasonyao@beyond-pharma.com
Country: China
ProdList: 858
Advantage: 60

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718 +86-13336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29793
Advantage: 60

Aikon International Limited

Tel: 025-66028182 18112977050
Fax: (3)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 15818
Advantage: 58

More

Less

View Lastest Price from Nitecapone manufacturers

Career Henan Chemical Co

Product: Nitecapone 116313-94-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200g
Release date: 2020-02-01

116313-94-1, NitecaponeRelated Search:

Benztropine mesylate Reserpine 2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide S-(-)-Carbidopa Nitecapone

3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione

Nitecapone

OR 462

3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione

3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione

GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia

2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-

Nitecapone, 10 mM in DMSO

116313-94-1

Intermediates & Fine Chemicals

Pharmaceuticals

Aromatics