Nitecapone
Description In vitro Biological activity- Product Name
- Nitecapone
- CAS No.
- 116313-94-1
- Chemical Name
- Nitecapone
- Synonyms
- OR 462;Nitecapone;Nitecapone, 10 mM in DMSO;3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione;3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione;3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione;2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-;GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia
- CBNumber
- CB51176592
- Molecular Formula
- C12H11NO6
- Formula Weight
- 265.22
- MOL File
- 116313-94-1.mol
Nitecapone Property
- Melting point:
- 171-173°C
- Boiling point:
- 495.3±45.0 °C(Predicted)
- Density
- 1.451±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 5.60±0.50(Predicted)
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML0671
- Product name
- Nitecapone
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $54.3
- Updated
- 2025/07/31
- Product number
- SML0671
- Product name
- Nitecapone
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $309
- Updated
- 2025/07/31
- Product number
- 18656
- Product name
- Nitecapone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 18656
- Product name
- Nitecapone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 18656
- Product name
- Nitecapone
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $288
- Updated
- 2024/03/01
Nitecapone Chemical Properties,Usage,Production
Description
Nitecapone (OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).It was patented as an antiparkinson medication.
In vitro
Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Biological activity
Nitecapone (OR-462) is a short-acting, orally active, catechol-O-methyltransferase (COMT) inhibitor with gastrointestinal protective and antioxidant activity. Nitecapone (OR-462) scavenges reactive oxygen species and nitric oxide and prevents lipid peroxidation.
Chemical Properties
Yellow Solid
Uses
Inhibitor for the treatment of Parkinson disease
Uses
Inhibitor for the treatment of Parkinson's disease.
Definition
ChEBI: Nitecapone is a hydroxycinnamic acid.
Biological Activity
Nitecapone is a short-acting inhibitor of catechol-O-methyltransferase (COMT). Nitecapone displays in vivo activity in peripheral tissues, but does not pentrate the blood brain barrier. The compound increases mechanical and thermal nociception, and reduces neuropathic pain in diabetic rats and in a spinal nerve ligation model.
in vivo
Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats[3].
| Animal Model: | Eighty-six male Wistar rats, weighing 140-350 g[3]. |
| Dosage: | 30 mg/kg (3.3 mL/kg). |
| Administration: | IP, once daily for 13 days. |
| Result: | Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h. Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia. Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats. |
Nitecapone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nitecapone manufacturers
- Product
- Nitecapone 116313-94-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01