Nitecapone

Description In vitro Biological activity

Product Name: Nitecapone
CAS No.: 116313-94-1
Chemical Name: Nitecapone
Synonyms: OR 462;Nitecapone;3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione;3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione;3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione;2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-;GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia
CBNumber: CB51176592
Molecular Formula: C12H11NO6
Formula Weight: 265.22
MOL File: 116313-94-1.mol

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Nitecapone Property

Melting point:: 171-173°C
Boiling point:: 495.3±45.0 °C(Predicted)
Density: 1.451±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: soluble15mg/mL, clear
pka: 5.60±0.50(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Toxicity: mouse,LD50,intraperitoneal,507mg/kg (507mg/kg),Pharmacology and Toxicology Vol. 69, Pg. 64, 1991.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0671
Product name: Nitecapone
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $73.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0671
Product name: Nitecapone
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $354
Updated: 2024/03/01

Cayman Chemical

Product number: 18656
Product name: Nitecapone
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 18656
Product name: Nitecapone
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 18656
Product name: Nitecapone
Purity: ≥98%
Packaging: 25mg
Price: $288
Updated: 2024/03/01

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Nitecapone Chemical Properties,Usage,Production

Description

Nitecapone (OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).It was patented as an antiparkinson medication.

In vitro

Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biological activity

Nitecapone (OR-462) is a short-acting, orally active, catechol-O-methyltransferase (COMT) inhibitor with gastrointestinal protective and antioxidant activity. Nitecapone (OR-462) scavenges reactive oxygen species and nitric oxide and prevents lipid peroxidation.

Chemical Properties

Yellow Solid

Uses

Inhibitor for the treatment of Parkinson disease

Uses

Inhibitor for the treatment of Parkinson's disease.

Definition

ChEBI: Nitecapone is a hydroxycinnamic acid.

Nitecapone Preparation Products And Raw materials

Raw materials

Preparation Products

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Nitecapone Suppliers

Canada 1 China 40 India 2 United States 8 USA 1 Global 52

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 028-87925786 18982287581
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 1374
Advantage: 58

ShangHai Wisacheam Pharmaceutical Co., Ltd.

Tel: 13817485796
Fax: QQ:895624079
Email: tim@wisacheampharm.com
Country: China
ProdList: 3689
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beyond Pharmaceutical Co., Ltd

Tel: +86-0571-81953185; 15381198709 +86-15381198709
Fax: 0571-89086206
Email: jasonyao@beyond-pharma.com
Country: China
ProdList: 829
Advantage: 60

Capot Chemical Co.,Ltd.

Tel: 571-85586718 +8613336195806
Fax: +86-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 29797
Advantage: 60

Aikon International Limited

Tel: 025-66028182 18112977050
Fax: (3)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 15820
Advantage: 58

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: 021-58958618
Email: xiaoyangw@gmail.com
Country: China
ProdList: 2129
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20569
Advantage: 58

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View Lastest Price from Nitecapone manufacturers

Career Henan Chemical Co

Product: Nitecapone 116313-94-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200g
Release date: 2020-02-01

116313-94-1, NitecaponeRelated Search:

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3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione

Nitecapone

OR 462

3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione

3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione

GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia

2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-

116313-94-1

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