Nitecapone

Description In vitro Biological activity

Product Name: Nitecapone
CAS No.: 116313-94-1
Chemical Name: Nitecapone
Synonyms: OR 462;Nitecapone;3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione;3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione;3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione;2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-;GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia
CBNumber: CB51176592
Molecular Formula: C12H11NO6
Formula Weight: 265.22
MOL File: 116313-94-1.mol

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Nitecapone Property

Melting point:: 171-173°C
Boiling point:: 495.3±45.0 °C(Predicted)
Density: 1.451±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: soluble15mg/mL, clear
pka: 5.60±0.50(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Toxicity: mouse,LD50,intraperitoneal,507mg/kg (507mg/kg),Pharmacology and Toxicology Vol. 69, Pg. 64, 1991.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0671
Product name: Nitecapone
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $73.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0671
Product name: Nitecapone
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $354
Updated: 2024/03/01

Cayman Chemical

Product number: 18656
Product name: Nitecapone
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 18656
Product name: Nitecapone
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 18656
Product name: Nitecapone
Purity: ≥98%
Packaging: 25mg
Price: $288
Updated: 2024/03/01

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Nitecapone Chemical Properties,Usage,Production

Description

Nitecapone (OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).It was patented as an antiparkinson medication.

In vitro

Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biological activity

Nitecapone (OR-462) is a short-acting, orally active, catechol-O-methyltransferase (COMT) inhibitor with gastrointestinal protective and antioxidant activity. Nitecapone (OR-462) scavenges reactive oxygen species and nitric oxide and prevents lipid peroxidation.

Chemical Properties

Yellow Solid

Uses

Inhibitor for the treatment of Parkinson disease

Uses

Inhibitor for the treatment of Parkinson's disease.

Definition

ChEBI: Nitecapone is a hydroxycinnamic acid.

Nitecapone Preparation Products And Raw materials

Raw materials

Preparation Products

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Nitecapone Suppliers

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View Lastest Price from Nitecapone manufacturers

Career Henan Chemical Co

Product: Nitecapone 116313-94-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200g
Release date: 2020-02-01

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Nitecapone

OR 462

3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione

3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione

GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia

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116313-94-1

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