Flumexadol
- Product Name
- Flumexadol
- CAS No.
- 30914-89-7
- Chemical Name
- Flumexadol
- Synonyms
- 1841CERM;CERM-1841;Flumexadol;2-(α,α,α-Trifluoro-m-tolyl)morpholine;2-[3-(Trifluoromethyl)phenyl]morpholine;Morpholine, 2-[3-(trifluoromethyl)phenyl]-
- CBNumber
- CB51178778
- Molecular Formula
- C11H12F3NO
- Formula Weight
- 231.21
- MOL File
- 30914-89-7.mol
Flumexadol Property
- Boiling point:
- 132 °C(Press: 10 Torr)
- Density
- 1.2081 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mg/mL (432.51 mM)
- pka
- 8.41±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T900660
- Product name
- 2-[3-(Trifluoromethyl)phenyl]morpholine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-0109485
- Product name
- Flumexadol
- Purity
- 98.87%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- HCH0126047
- Product name
- 2-[3-(TRIFLUOROMETHYL)PHENYL]-MORPHOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $787.5
- Updated
- 2021/12/16
- Product number
- HCH0126047
- Product name
- 2-[3-(TRIFLUOROMETHYL)PHENYL]-MORPHOLINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1663.02
- Updated
- 2021/12/16
- Product number
- HCH0126047
- Product name
- 2-[3-(TRIFLUOROMETHYL)PHENYL]-MORPHOLINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2223.51
- Updated
- 2021/12/16
Flumexadol Chemical Properties,Usage,Production
Biological Activity
Flumexadol is an orally active non-narcotic analgesic. It is a selective and affinity agonist of the 5-HT2C receptor with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, 40-fold more selective than the 5-HT2A receptor.
in vivo
In rats and dogs dosed with 14 C-Flumexadol (CERM1841), the 14 C is excreted in the urine. The 14 C eliminated in the faeces of dog is significantly higher than for rat. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances. The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.
div>
target
| 5-HT 2C Receptor 25 nM (Ki) |