Pharmacological Study
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Posatirelin

Pharmacological Study
Product Name
Posatirelin
CAS No.
78664-73-0
Chemical Name
Posatirelin
Synonyms
RGH-2202;BRN6006446;BRN 6006446;BRN-6006446;Posatirelin;Posatirelinum;N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2;L-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-L-leucyl-;N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide
CBNumber
CB51179553
Molecular Formula
C17H28N4O4
Formula Weight
352.432
MOL File
78664-73-0.mol
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Posatirelin Property

Melting point:
214-216°
alpha 
D25 -80.2° (c = 1 in acetic acid)
Boiling point:
739.6±60.0 °C(Predicted)
Density 
1.214±0.06 g/cm3(Predicted)
pka
13.56±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
462826
Product name
Posatirelin
Packaging
5mg
Price
$305
Updated
2021/12/16
TRC
Product number
P689665
Product name
Posatirelin
Packaging
10mg
Price
$770
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0006881
Product name
N-[6-OXOPIPERIDIN-2(S)-YLCARBONYL]-L-LEUCYL-L-PROLINAMIDE
Purity
95.00%
Packaging
5MG
Price
$503.98
Updated
2021/12/16
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Posatirelin Chemical Properties,Usage,Production

Pharmacological Study

Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic deficit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a significant improvement in intellectual performance, orientation, motivation and memory as compared to controls. The drug was well tolerated.

Description

Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated.

Uses

Posatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease.

Definition

ChEBI: Posatirelin is an oligopeptide.

Posatirelin Preparation Products And Raw materials

Raw materials

Preparation Products

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Posatirelin Suppliers

Jiangsu Hongmin Pharmaceutical Co., Ltd.
Tel
18221292452
Email
fannieliu@glschina.com
Country
China
ProdList
6799
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24131
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58

78664-73-0, PosatirelinRelated Search:


  • Posatirelin
  • N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2
  • RGH-2202
  • N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide
  • BRN 6006446
  • BRN6006446
  • BRN-6006446
  • Posatirelinum
  • L-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-L-leucyl-
  • 78664-73-0