Telatinib

ChemicalBook > CAS DataBase List > Telatinib

Product Name: Telatinib
CAS No.: 332012-40-5
Chemical Name: Telatinib
Synonyms: CS-361;CS-1854;Telatnib;Bay 57-9352;Unii-18p7197Q7j;Telatinib USP/EP/BP;Telatinib(BAY 57-9352);Telatinib, 10 mM in DMSO;4-((4-(4-chlorophenylamino)furo[2,3-d]pyridazin-7-yloxy)methyl)-N-methylpicolinamide;4-[[4-(4-Chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methyl-pyridine-2-carboxamide
CBNumber: CB51179861
Molecular Formula: C20H16ClN5O3
Formula Weight: 409.83
MOL File: 332012-40-5.mol

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Telatinib Property

Boiling point:: 713.6±60.0 °C(Predicted)
Density: 1.417
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥20.5 mg/mL in DMSO
form: solid
pka: 14.18±0.46(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26203
Product name: Telatinib
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 26203
Product name: Telatinib
Packaging: 50mg
Price: $728
Updated: 2024/03/01

Cayman Chemical

Product number: 26203
Product name: Telatinib
Packaging: 10mg
Price: $167
Updated: 2024/03/01

Cayman Chemical

Product number: 26203
Product name: Telatinib
Packaging: 25mg
Price: $389
Updated: 2024/03/01

TRC

Product number: T015700
Product name: Telatinib
Packaging: 10mg
Price: $145
Updated: 2021/12/16

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Telatinib Chemical Properties,Usage,Production

Description

Telatinib is a multi-kinase inhibitor that inhibits VEGF receptor 2 (VEGFR2), VEGFR3, PDGFRα, and c-Kit (IC₅₀s = 6, 4, 15, and 1 nM, respectively). It also binds to the transmembrane region of the ABCG2 efflux transporter and enhances intracellular accumulation of [³H]-mitoxantrone in ABCG2-overexpressing cells. Telatinib (15 mg/kg) decreases tumor growth rate and size in an H460/MX20 mouse xenograft model.

Uses

Telatinib small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. Telatinib is used therapeutically in patients with advanced solid tumors.

Uses

Telatinib (BAY 57-9352) is an orally available, potent multitargeted VEGFR-2, VEGFR-3, PDGFR-β and c-Kit tyrosine kinases inhibitor with an IC50 of 19 nM for the inhibition of VEGFR-2 autophosphorylation.

target

c-Kit

References

[1]. steeghs, n., et al., hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. clin cancer res, 2008. 14(11): p. 3470-6.
[2]. strumberg, d., et al., phase i dose escalation study of telatinib (bay 57-9352) in patients with advanced solid tumours. br j cancer, 2008. 99(10): p. 1579-85.
[3]. sodani, k., et al., telatinib reverses chemotherapeutic multidrug resistance mediated by abcg2 efflux transporter in vitro and in vivo. biochem pharmacol, 2014. 89(1): p. 52-61.
[4]. eskens, f.a., et al., phase i dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-kit, in patients with advanced or metastatic solid tumors. j clin oncol, 2009. 27(25): p. 4169-76.

Telatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Telatinib manufacturers

Dideu Industries Group Limited

Product: Telatinib 332012-40-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

332012-40-5, TelatinibRelated Search:

Nilotinib Phosphomycin Sodium Fruquintinib|HMPL-013 Canertinib Tilatinib Tilatinib 17-AAG Axitinib Nintedanib Dasatinib MG-132 Ibrutinib Crenolanib (CP-868596) Erlotinib Antienite Bosutinib Afatinib

2-Pyridinecarboxamide, 4-(((4-((4-chlorophenyl)amino)furo(2,3-D)pyridazin-7-yl)oxy)methyl)-N-methyl-

Bay 57-9352

Unii-18p7197Q7j

Telatinib(BAY 57-9352)

4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide

4-((4-(4-chlorophenylamino)furo[2,3-d]pyridazin-7-yloxy)methyl)-N-methylpicolinamide

4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide Telatinib(BAY57-9352)

Telatnib

4-[[4-(4-Chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methyl-pyridine-2-carboxamide

CS-361

CS-1854

Telatinib USP/EP/BP

Telatinib, 10 mM in DMSO

332012-40-5

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Inhibitors