2-(S)-Hydroxy-3-methylbutyric acid methyl ester

Uses

Product Name: 2-(S)-Hydroxy-3-methylbutyric acid methyl ester
CAS No.: 24347-63-5
Chemical Name: 2-(S)-Hydroxy-3-methylbutyric acid methyl ester
Synonyms: methyl (S)-2-hydroxy-3-methylbutanoate;(S)-Methyl 2-hydroxy-3-methylbutanoate;methyl (2s)-2-hydroxy-3-methylbutanoate;2-(S)-Hydroxy-3-methylbutyric acid methyl ester;(S)-Methyl 2-hydroxy-3-methylbutanoate - [M92121];Butanoic acid, 2-hydroxy-3-methyl-, methyl ester, (2S)-
CBNumber: CB51180366
Molecular Formula: C6H12O3
Formula Weight: 132.16
MOL File: 24347-63-5.mol

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2-(S)-Hydroxy-3-methylbutyric acid methyl ester Property

Boiling point:: 61-62 °C(Press: 15 Torr)
Density: 1.021±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.94±0.20(Predicted)
form: liquid
color: Colourless
LogP: 0.160 (est)

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Safety

HS Code: 2918199890

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Synthonix

Product number: M92121
Product name: (S)-Methyl 2-hydroxy-3-methylbutanoate
Purity: 97%
Packaging: 100mg
Price: $45
Updated: 2026/05/06

Synthonix

Product number: M92121
Product name: (S)-Methyl 2-hydroxy-3-methylbutanoate
Purity: 97%
Packaging: 250mg
Price: $49
Updated: 2026/05/06

Synthonix

Product number: M92121
Product name: (S)-Methyl 2-hydroxy-3-methylbutanoate
Purity: 97%
Packaging: 1g
Price: $51
Updated: 2026/05/06

Synthonix

Product number: M92121
Product name: (S)-Methyl 2-hydroxy-3-methylbutanoate
Purity: 97%
Packaging: 5g
Price: $140
Updated: 2026/05/06

Synthonix

Product number: M92121
Product name: (S)-Methyl 2-hydroxy-3-methylbutanoate
Purity: 97%
Packaging: 25g
Price: $530
Updated: 2026/05/06

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2-(S)-Hydroxy-3-methylbutyric acid methyl ester Chemical Properties,Usage,Production

Uses

(S)-Methyl 2-hydroxy-3-methylbutanoate is a useful research chemical.

Synthesis

67-56-1

17407-55-5

24347-63-5

Methanol (14.5 mL, 360 mmol) and p-toluenesulfonic acid monohydrate (0.68 g, 3.6 mmol) were added to a solution of (S)-(+)-2-hydroxy-3-methylbutyric acid (14.20 g, 120 mmol) in carbon tetrachloride (40 mL). The reaction mixture was refluxed under anhydrous conditions for 10 hours. Upon completion of the reaction, the mixture was cooled to room temperature, washed sequentially with water (15 mL) and saturated aqueous sodium bicarbonate solution (10 mL), dried over magnesium sulfate, and concentrated under reduced pressure. Purification of the residue by distillation afforded methyl (S)-2-hydroxy-3-methylbutanoate (13.03 g, 82% yield) as a colorless oil; boiling point 62-63 °C/15 Torr; specific optical rotation [α]D = +23.7 (c 1.00, CHCl3), literature value [α]D = +24.3 (c 1.00, CHCl3); 1H NMR ( CDCl3) δ 0.82 (d, J = 6.9 Hz, 3H, 3-Me), 0.98 (d, J = 6.9 Hz, 3H, 3-Me), 2.03 (m, 1H, 3-H), 2.83 (d, J = 6.2 Hz, 1H, OH), 3.75 (s, 3H, CO2Me), 4.01 (dd, J = 6.2, 3.6 Hz 1H, 2-H); 13C NMR (CDCl3) δ 15.9, 18.6, 32.1, 52.2, 75.0, 175.3; IR (thin film) νmax: 3483, 1735 cm-1.

References

[1] Journal of the American Chemical Society, 1990, vol. 112, # 21, p. 7659 - 7672
[2] Tetrahedron Letters, 1989, vol. 30, # 29, p. 3757 - 3760
[3] Journal of Chemical Research, Miniprint, 1998, # 1, p. 126 - 142
[4] Heterocycles, 1999, vol. 51, # 6, p. 1321 - 1343
[5] Organic and Biomolecular Chemistry, 2005, vol. 3, # 20, p. 3749 - 3756

2-(S)-Hydroxy-3-methylbutyric acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(S)-Hydroxy-3-methylbutyric acid methyl ester Suppliers

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2-(S)-Hydroxy-3-methylbutyric acid methyl ester

(S)-Methyl 2-hydroxy-3-methylbutanoate

methyl (S)-2-hydroxy-3-methylbutanoate

Butanoic acid, 2-hydroxy-3-methyl-, methyl ester, (2S)-

methyl (2s)-2-hydroxy-3-methylbutanoate

(S)-Methyl 2-hydroxy-3-methylbutanoate - [M92121]

24347-63-5