Zongertinib
- Product Name
- Zongertinib
- CAS No.
- 2728667-27-2
- Chemical Name
- Zongertinib
- Synonyms
- BI-1810631;Zongertinib;Zostertinib;BLU-451(LNG451);Toremifen citrate;Zostertinib BI-1810631;Zongertinib/BI 1810631;azol-5-yl)oxy]phenyl]amino]pyrimido[5,4-d]pyrimidin-2-yl]-4-piperidinyl]-;N-[1-[4-[3-methyl-4-(1-methylbenzimidazol-5-yl)oxy-anilino]pyrimido[5,4-d]pyrimidin-6-yl]-4-piperidyl]prop-2-enamide;N-(1-(8-((3-methyl-4-((1-methyl-1H-benzo[d]imidazol-5-yl)oxy)phenyl)amino)pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl)acrylamide
- CBNumber
- CB512094450
- Molecular Formula
- C29H29N9O2
- Formula Weight
- 535.6
- MOL File
- 2728667-27-2.mol
Zongertinib Property
- Density
- 1.39±0.1 g/cm3(Predicted)
- form
- Solid
- pka
- 14.16±0.20(Predicted)
- color
- Light yellow to green yellow
- InChIKey
- YSGNGFPNTLERCR-UHFFFAOYSA-N
- SMILES
- C(NC1CCN(C2=NC=C3N=CN=C(NC4=CC=C(OC5=CC=C6N(C)C=NC6=C5)C(C)=C4)C3=N2)CC1)(=O)C=C
Zongertinib Chemical Properties,Usage,Production
Description
Zongertinib (also known as BI 1810631) is an investigational irreversible tyrosine kinase inhibitor (TKI) that selectively inhibits HER2 (ERBB2) while inhibiting epidermal growth factor receptor (EGFR), thereby limiting associated toxicity. This oral targeted therapy is being developed for the treatment of advanced non-small cell lung cancer (NSCLC) with HER2 (ERRB2) mutations.
Uses
Zongertinib (BI 1810631) is a potent and selective HER2 and EGFR tyrosine kinase inhibitor with IC50 values of 13 nM and 579 nM, respectively. Zongertinib has antitumor activity and can be used in the study of multiple solid tumors[1][2][3].
References
[1] WHO Drug Informat ion - World Health Organization (WHO).
[2] Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800. 2021-10-28.
[3] Li S, et al. Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer. Cancers (Basel). 2023 May 24;15(11):2899. DOI:10.3390/cancers15112899
Zongertinib Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Zongertinib manufacturers
- Product
- Zongertinib; BI-1810631 2728667-27-2
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 99% HPLC
- Supply Ability
- 10000
- Release date
- 2024-09-19