Romifidine hydrochloride

Product Name: Romifidine hydrochloride
CAS No.: 65896-14-2
Chemical Name: Romifidine hydrochloride
Synonyms: Sedivet;STH 2130Cl;Romifidine HCl;Romifidine Hydrochloride;Romifidine Hydrochloride, Monohydrochloride;Romifidine hydrochloride 100 μg/mL in Acetonitrile;N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-ylamine HCl;N-(2-BroMo-6-fluorophenyl)-4,5-dihydro-1H-iMidazol-2-aMine Hydrochloride;1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, monohydrochloride;1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, hydrochloride (1:1)
CBNumber: CB51210096
Molecular Formula: C9H10BrClFN3
Formula Weight: 0
MOL File: 65896-14-2.mol

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Romifidine hydrochloride Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White
InChI: InChI=1S/C9H9BrFN3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
InChIKey: SDXVSIWCVTYYQN-UHFFFAOYSA-N
SMILES: C1(NC2=C(F)C=CC=C2Br)NCCN=1.[H]Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: R640050
Product name: RomifidineHydrochloride
Packaging: 50mg
Price: $350
Updated: 2021/12/16

TRC

Product number: R640050
Product name: RomifidineHydrochloride
Packaging: 100mg
Price: $670
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007049
Product name: ROMIFIDINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 50MG
Price: $721.88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007049
Product name: ROMIFIDINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 25MG
Price: $323.4
Updated: 2021/12/16

Ambeed

Product number: A1061990
Product name: N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-aminehydrochloride
Purity: 98+%
Packaging: 1g
Price: $564
Updated: 2021/12/16

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Romifidine hydrochloride Chemical Properties,Usage,Production

Description

Romifidine hydrochloride [N-(2-b romifidineo-6-fluoro-phenyl)- 4,5-dihydro-1H-imidazol-2-amine mono-hydrochloride, C9H9BrFN3, MW 258.1; romifidine] is an imidazole derivative with potent a2-adrenoceptor agonist properties. It is commonly used in equine practice to provide sedation, analgesia, and muscle relaxation. A comparative study reported that an intravenous (i.v.) dose of 80 μg/kg romifidine is equipotent to 1 mg/kg xylazine i.v. and 20 μg/kg detomidine i.v.[1]. Typical signs of sedation include muscle relaxation, decreased head height (HH), diminished responsiveness to external stimuli, and postural abnormalities following romifidine administration. Furthermore, romifidine possesses antinociceptive activity. As an analgesic, it reduces anesthetic requirements for isoflurane in horses.

Uses

An α2 agonist use as a sedative and analgesic.

Uses

As an α2 agonist used as a sedative and analgesic, RoMifidine Hydrochloride is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses.

Mechanism of action

Alpha2 agonists decrease release of neurotransmitters from the neuron. The proposed mechanism whereby they decrease transmission is via binding to presynaptic alpha2 receptors (negative feedback receptors).

in vivo

Romifidine hydrochloride (80 μg/kg; i.v. once) produces sedative effects with significantly greater drooping during the 45-90 min time period in welsh mountain ponies^[1]. Romifidine hydrochloride (40, 80 and 120 mg/kg; i.v. at seven-day intervals) shows a shallower and shorter-lived sedation than with detomidine in horses^[2].

References

[1] M. WOJTASIAK-WYPART. “Pharmacokinetic profile and pharmacodynamic effects of romifidine hydrochloride in the horse.” Journal of veterinary pharmacology and therapeutics 35 5 (2012): 478–488.

Romifidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Romifidine hydrochloride Suppliers

Canada 1 China 38 India 2 United States 1 Global 42

Tianjin Keluo Pharmaceutical Technology Co. LTD

Tel: 022-23869539 18920052327
Fax: 022-83711180
Email: 281258989@qq.com
Country: China
ProdList: 63
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Wuhan Sunrise Technology Development Co., Ltd.

Tel: 27-027-83314682 13554138826
Fax: +86 (27) 8331-4682
Email: whsrtech@vip.163.com
Country: China
ProdList: 246
Advantage: 62

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Jiangsu aikang biomedical research and development co., LTD

Tel: 025-58859352 13155353615
Email: qzhang@aikonchem.com
Country: China
ProdList: 15525
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15116
Advantage: 58

Nanjing Ze Feng biological medicine technology Co., Ltd.

Tel: 18851912129 18851912129;
Email: 1670471576@qq.com
Country: China
ProdList: 800
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

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View Lastest Price from Romifidine hydrochloride manufacturers

RongNa Biotechnology Co.,Ltd

Product: Romifidine hydrochloride 65896-14-2
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 100kg
Release date: 2025-05-22

Xi an Biohorlden Industry Trade Co Ltd

Product: Romifidine hydrochloride 65896-14-2
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10 kg
Release date: 2025-04-22

Guangdong Junhua Chemical Co., Ltd

Product: Romifidine hydrochloride 65896-14-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.9
Supply Ability: 10 tons
Release date: 2025-02-26

65896-14-2, Romifidine hydrochlorideRelated Search:

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Romifidine hydrochloride 100 μg/mL in Acetonitrile

65896-14-2

C9H10BrClFN3

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals