Romifidine hydrochloride
- Product Name
- Romifidine hydrochloride
- CAS No.
- 65896-14-2
- Chemical Name
- Romifidine hydrochloride
- Synonyms
- Sedivet;STH 2130Cl;Romifidine HCl;Romifidine Hydrochloride;Romifidine Hydrochloride, Monohydrochloride;N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-ylamine HCl;N-(2-BroMo-6-fluorophenyl)-4,5-dihydro-1H-iMidazol-2-aMine Hydrochloride;1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, monohydrochloride;1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, hydrochloride (1:1)
- CBNumber
- CB51210096
- Molecular Formula
- C9H10BrClFN3
- Formula Weight
- 0
- MOL File
- 65896-14-2.mol
Romifidine hydrochloride Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White
- InChI
- InChI=1S/C9H9BrFN3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
- InChIKey
- SDXVSIWCVTYYQN-UHFFFAOYSA-N
- SMILES
- C1(NC2=C(F)C=CC=C2Br)NCCN=1.[H]Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- R640050
- Product name
- RomifidineHydrochloride
- Packaging
- 50mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- R640050
- Product name
- RomifidineHydrochloride
- Packaging
- 100mg
- Price
- $670
- Updated
- 2021/12/16
- Product number
- API0007049
- Product name
- ROMIFIDINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $323.4
- Updated
- 2021/12/16
- Product number
- API0007049
- Product name
- ROMIFIDINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $721.88
- Updated
- 2021/12/16
- Product number
- A1061990
- Product name
- N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-aminehydrochloride
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $151
- Updated
- 2021/12/16
Romifidine hydrochloride Chemical Properties,Usage,Production
Description
Romifidine hydrochloride [N-(2-b romifidineo-6-fluoro-phenyl)- 4,5-dihydro-1H-imidazol-2-amine mono-hydrochloride, C9H9BrFN3, MW 258.1; romifidine] is an imidazole derivative with potent a2-adrenoceptor agonist properties. It is commonly used in equine practice to provide sedation, analgesia, and muscle relaxation. A comparative study reported that an intravenous (i.v.) dose of 80 μg/kg romifidine is equipotent to 1 mg/kg xylazine i.v. and 20 μg/kg detomidine i.v.[1]. Typical signs of sedation include muscle relaxation, decreased head height (HH), diminished responsiveness to external stimuli, and postural abnormalities following romifidine administration. Furthermore, romifidine possesses antinociceptive activity. As an analgesic, it reduces anesthetic requirements for isoflurane in horses.
Uses
An α2 agonist use as a sedative and analgesic.
Uses
As an α2 agonist used as a sedative and analgesic, RoMifidine Hydrochloride is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses.
Mechanism of action
Alpha2 agonists decrease release of neurotransmitters from the neuron. The proposed mechanism whereby they decrease transmission is via binding to presynaptic alpha2 receptors (negative feedback receptors).
References
[1] M. WOJTASIAK-WYPART. “Pharmacokinetic profile and pharmacodynamic effects of romifidine hydrochloride in the horse.” Journal of veterinary pharmacology and therapeutics 35 5 (2012): 478–488.
Romifidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Romifidine hydrochloride Suppliers
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19553
- Advantage
- 58
View Lastest Price from Romifidine hydrochloride manufacturers
- Product
- Romifidine hydrochloride 65896-14-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10
- Release date
- 2024-07-14