BENAZEPRIL HCL
- Product Name
- BENAZEPRIL HCL
- CAS No.
- 3202-55-9
- Chemical Name
- BENAZEPRIL HCL
- Synonyms
- ap1288;brl1288;Benapryzine HCl;benapryzinehydrochloride;Benaprizine Hydrochloride;benzilicacid,2-(ethylpropylamino)ethylester,hydrochloride;alpha-hydroxy-alpha-phenyl-benzeneaceticaci2-(ethylpropylamino)ethyles
- CBNumber
- CB5122019
- Molecular Formula
- C24H29ClN2O5
- Formula Weight
- 460.95
- MOL File
- 3202-55-9.mol
BENAZEPRIL HCL Property
- Melting point:
- 164-166°
N-Bromosuccinimide Price
- Product number
- API0016041
- Product name
- BENAPRYZINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.01
- Updated
- 2021/12/16
BENAZEPRIL HCL Chemical Properties,Usage,Production
Originator
Brizin,Beecham,UK,1973
Uses
Anticholinergic.
Manufacturing Process
A methanolic solution of sodium methoxide [from sodium (0.2 gram) and dry
methanol (3 ml)] was added dropwise during 20 minutes to a boiling solution
of methyl α,α-diphenylglycollate (11 grams) and 2-ethylpropylaminoethanol (6
grams) in light petroleum (150 ml, BP 80°-100°C) and the methanol that
separated was removed by using a Dean and Starke apparatus. At the end of
5 hours no further separation of methanol occurred and the reaction mixture
after being washed with water (3 x 20 ml) was extracted with 1N hydrochloric
acid (3 x 30 ml).
The acid extracts (after washing with 50 ml ether) were made alkaline with
aqueous 5 N sodium hydroxide solution, the liberated base was extracted into
ether (4 x 50 ml) and the ether extracts were dried (MgSO4). Treatment of
the extracts with hydrogen chloride gave the hydrochloride (11 grams, 70%),
which was obtained as rectangular plates, MP 164° to 166°C, after several
crystallizations from butanone.
Therapeutic Function
Anticholinergic, Antiparkinsonian
BENAZEPRIL HCL Preparation Products And Raw materials
Raw materials
Preparation Products
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