ChemicalBook > CAS DataBase List > 2'-Deoxy-2'-fluoroguanosine

2'-Deoxy-2'-fluoroguanosine

Product Name
2'-Deoxy-2'-fluoroguanosine
CAS No.
78842-13-4
Chemical Name
2'-Deoxy-2'-fluoroguanosine
Synonyms
2'-F-G;2'-FdG;2'-F-2'-dG;2'-F-2'-dG;Guanosine Impurity 9;2'-F-2'-deoxyguanosine;2'-F-2'-deoxyguanosine;2'-Deoxy-2'-fuoroguanosine;2'-deoxy-2'-fluoroguanosine;2'-Fluoro-2'-deoxyguanosine
CBNumber
CB51231453
Molecular Formula
C10H12FN5O4
Formula Weight
285.23
MOL File
78842-13-4.mol
More
Less

2'-Deoxy-2'-fluoroguanosine Property

Melting point:
262-264 °C(Solv: water (7732-18-5))
Density 
2.17±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO : 50 mg/mL (175.30 mM)
pka
9?+-.0.20(Predicted)
form 
Powder
color 
White to Off-white
InChI
InChI=1S/C10H12FN5O4/c11-4-6(18)3(1-17)20-9(4)16-2-13-5-7(16)14-10(12)15-8(5)19/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4-,6-,9-/m1/s1
InChIKey
UXUZARPLRQRNNX-DXTOWSMRSA-N
SMILES
OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](F)[C@@H]1O
More
Less

Safety

HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Alfa Aesar
Product number
J64055
Product name
2'-Fluoro-2'-deoxyguanosine
Purity
99%
Packaging
250mg
Price
$32.65
Updated
2024/03/01
Alfa Aesar
Product number
J64055
Product name
2'-Fluoro-2'-deoxyguanosine, 99%
Packaging
1g
Price
$117.65
Updated
2024/03/01
TRC
Product number
D235125
Product name
2''-Deoxy-2''-fluoroguanosine
Packaging
250mg
Price
$140
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND02828
Product name
2'-Deoxy-2'-fluoroguanosine
Packaging
2g
Price
$170
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
56441
Product name
2??-Deoxy-2??-fluoroguanosine
Packaging
500mg
Price
$190
Updated
2021/12/16
More
Less

2'-Deoxy-2'-fluoroguanosine Chemical Properties,Usage,Production

Uses

2''-Deoxy-2''-fluoroguanosine, can be used as powerful tool for structural manipulation of G-quadruplexes. It is also a influenza viral polymerase inhibitor like Ribavirin (R414475), used as a antiviral drug against avian (H5N1) influenza virus.

Definition

2'-Deoxy-2'-fluoroguanosine is an analog of guanosine that inhibits the viral life cycle. It is a competitive inhibitor of the viral transcriptase enzyme, which prevents RNA synthesis and subsequent protein synthesis. 2'-Deoxy-2'-fluoroguanosine has been shown to inhibit the growth of wild-type viruses in cell culture and to be effective against resistant mutants in cell culture. This drug has also been shown to inhibit the replication of herpes simplex virus type 1 (HSV-1) and influenza virus type A/WSN/33 (H1N1) in cell culture, as well as inhibiting the production of rna from these viruses.

Synthesis

The synthesis of 2'-deoxy-2'-fluoroguanosine was accomplished using tetraisopropyldisiloxanyl (TPDS) protected 9-beta-D-arabinofuranosylguanine as starting material, and conversion to the intermediate diisobutyryl-arabinofuranosylguanosine. Deprotection of the TPDS group, was followed by protection of the hydroxyl group with THP to give diisobutyryl di-THP protected arabinofuranosylguanine. Selective O-deacylation and triflation was followed by treatment of the crude product with fluoride, then deprotection of the THP groups.

References

[1] M. Ikehara, J. Imura. “Studies on Nucleosides and Nucleotides. LXXXVII. Purine Cyclonucleosides. XLII. Synthesis of 2’-Deoxy-2’-fluoroguanosine.” Chemical & pharmaceutical bulletin 22 1 (1981): 1034–1038.
[2] G V Zaitseva. “Chemical and enzymatic synthesis and antiviral properties of 2’-deoxy-2’-fluoroguanosine.” Nucleosides & nucleotides 18 4–5 (1999): 687–8.
[3] M Tisdale. “Inhibition of influenza virus transcription by 2’-deoxy-2’-fluoroguanosine.” Antimicrobial Agents and Chemotherapy 39 11 (1995): 2454–8.

2'-Deoxy-2'-fluoroguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2'-Deoxy-2'-fluoroguanosine Suppliers

Zhengzhou First biochem technology Co.,Ltd.
Tel
0371-68865717 13213090566
Email
firstbio@126.com
Country
China
ProdList
15
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 13626641628
Email
jiangnan@huidabiotech.com
Country
China
ProdList
3656
Advantage
58
Hefei Huana Biomedical Technology Co.,Ltd
Tel
17333066501
Email
shengwen.fang@huanaok.com.cn
Country
China
ProdList
95
Advantage
58
Hangzhou Huiyi Biotechnology Co., LTD
Tel
0571-89918262 13357170655
Email
chenlingwei@hizyme.com
Country
China
ProdList
282
Advantage
58
HeFei ShenShen Medical Technology Co.,Ltd
Tel
15375050680; 15375050680
Email
gdz2.71828@163.com
Country
China
ProdList
17
Advantage
58
Suzhou Heshengyuan Biopharmaceutical Technology Co., Ltd
Tel
13918488572 13918488572
Email
he_wei_ryan@synorbio.com
Country
China
ProdList
51
Advantage
58
Allbiosyn Biotechnology Co.,LTD
Tel
18666985712
Email
info@allbiosyn.com
Country
China
ProdList
285
Advantage
58
Xinxiang Yicheng Biotechnology Co.,LTD
Tel
0373-6014999 18937330588
Email
xxycswsale@163.com
Country
China
ProdList
69
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
Advantage
61
More
Less

View Lastest Price from 2'-Deoxy-2'-fluoroguanosine manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
2'-Deoxy-2'-fluoroguanosine 78842-13-4
Price
US $0.00/g
Min. Order
100g
Purity
≥98%(HPLC)
Supply Ability
20t
Release date
2023-05-11
Yunbio Tech Co.,Ltd.
Product
2'-Deoxy-2'-fluoroguanosine 78842-13-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
300KGS
Release date
2023-03-04
Zhejiang Hengkang Pharmaceutical Co., Ltd.
Product
2'-Deoxy-2'-fluoroguanosine 78842-13-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg per month
Release date
2022-12-27

78842-13-4, 2'-Deoxy-2'-fluoroguanosineRelated Search:


  • 2'-deoxy-2'-fluoroguanosine
  • 2'-FdG
  • 2'-Fluoro -2'-deoxyguanosine
  • 2'-F-2'-dG
  • Guanosine,2'-deoxy-2'-fluoro-
  • 2-amino-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
  • 2'-Deoxy-2'-fluoroguanosine USP/EP/BP
  • 2'-F-G
  • 2'-F-2'-deoxyguanosine
  • nucleoside,strains,tract,Influenza Virus,Inhibitor,analog,fever,nasal,inhibit,virus,influenza,upper,2′Deoxy2′fluoroguanosine,2′ Deoxy 2′ fluoroguanosine,respiratory,inflammation
  • 2-Amino-9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
  • Guanosine Impurity 9
  • 2'-Fluoro-2'-Deoxyguanosine (FdG)
  • 2'-Fluoro-2'-deoxyguanosine
  • 2'-Deoxy-2'-fluoroguanosine
  • 2'-Deoxy-2'-fuoroguanosine
  • 2'-F-2'-deoxyguanosine
  • 2'-F-2'-dG
  • 78842-13-4
  • 78842-23-4
  • Nucleosides
  • Modified(deoxy)nucleoside
  • Nucleosides-2'-F Nucleosides