2'-Deoxy-2'-fluoroguanosine

Product Name: 2'-Deoxy-2'-fluoroguanosine
CAS No.: 78842-13-4
Chemical Name: 2'-Deoxy-2'-fluoroguanosine
Synonyms: 2'-F-G;2'-FdG;2'-F-2'-dG;Guanosine Impurity 9;2'-F-2'-deoxyguanosine;2'-deoxy-2'-fluoroguanosine;2'-Fluoro-2'-deoxyguanosine;2'-Deoxy-2'-fluoroguanosine;2'-Fluoro -2'-deoxyguanosine;Guanosine,2'-deoxy-2'-fluoro-
CBNumber: CB51231453
Molecular Formula: C10H12FN5O4
Formula Weight: 285.23
MOL File: 78842-13-4.mol

More

Less

2'-Deoxy-2'-fluoroguanosine Property

Melting point:: 262-264 °C(Solv: water (7732-18-5))
Density: 2.17±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO : 50 mg/mL (175.30 mM)
pka: 9?+-.0.20(Predicted)
form: Powder
color: White to Off-white
InChI: InChI=1S/C10H12FN5O4/c11-4-6(18)3(1-17)20-9(4)16-2-13-5-7(16)14-10(12)15-8(5)19/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4-,6-,9-/m1/s1
InChIKey: UXUZARPLRQRNNX-DXTOWSMRSA-N
SMILES: OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](F)[C@@H]1O

More

Less

Safety

HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Alfa Aesar

Product number: J64055
Product name: 2'-Fluoro-2'-deoxyguanosine
Purity: 99%
Packaging: 250mg
Price: $32.65
Updated: 2024/03/01

Alfa Aesar

Product number: J64055
Product name: 2'-Fluoro-2'-deoxyguanosine, 99%
Packaging: 1g
Price: $117.65
Updated: 2024/03/01

TRC

Product number: D235125
Product name: 2''-Deoxy-2''-fluoroguanosine
Packaging: 250mg
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND02828
Product name: 2'-Deoxy-2'-fluoroguanosine
Packaging: 2g
Price: $170
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 56441
Product name: 2??-Deoxy-2??-fluoroguanosine
Packaging: 500mg
Price: $190
Updated: 2021/12/16

More

Less

2'-Deoxy-2'-fluoroguanosine Chemical Properties,Usage,Production

Uses

2''-Deoxy-2''-fluoroguanosine, can be used as powerful tool for structural manipulation of G-quadruplexes. It is also a influenza viral polymerase inhibitor like Ribavirin (R414475), used as a antiviral drug against avian (H5N1) influenza virus.

Definition

2'-Deoxy-2'-fluoroguanosine is an analog of guanosine that inhibits the viral life cycle. It is a competitive inhibitor of the viral transcriptase enzyme, which prevents RNA synthesis and subsequent protein synthesis. 2'-Deoxy-2'-fluoroguanosine has been shown to inhibit the growth of wild-type viruses in cell culture and to be effective against resistant mutants in cell culture. This drug has also been shown to inhibit the replication of herpes simplex virus type 1 (HSV-1) and influenza virus type A/WSN/33 (H1N1) in cell culture, as well as inhibiting the production of rna from these viruses.

Synthesis

The synthesis of 2'-deoxy-2'-fluoroguanosine was accomplished using tetraisopropyldisiloxanyl (TPDS) protected 9-beta-D-arabinofuranosylguanine as starting material, and conversion to the intermediate diisobutyryl-arabinofuranosylguanosine. Deprotection of the TPDS group, was followed by protection of the hydroxyl group with THP to give diisobutyryl di-THP protected arabinofuranosylguanine. Selective O-deacylation and triflation was followed by treatment of the crude product with fluoride, then deprotection of the THP groups.

2'-Deoxy-2'-fluoroguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2'-Deoxy-2'-fluoroguanosine Suppliers

China 151 India 2 United Kingdom 3 United States 12 Global 168

Zhengzhou First biochem technology Co.,Ltd.

Tel: 0371-68865717 13213090566
Email: firstbio@126.com
Country: China
ProdList: 15
Advantage: 58

Nanjing Baifuli Technology Co., Ltd.

Tel: 25-25-58740604 15951658055
Fax: +86-25-58356858
Email: sales@unisyn.cn
Country: China
ProdList: 537
Advantage: 58

Hangzhou Hesheng Taiyi Biotechnology Co. , Ltd.

Tel: 15868607770
Email: hstysales@126.com
Country: China
ProdList: 1160
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 13626641628
Email: jiangnan@huidabiotech.com
Country: China
ProdList: 3661
Advantage: 58

Nanjing GoodGene Biotechnology Co., Ltd

Tel: 13335632219
Email: 3152731197@qq.com
Country: China
ProdList: 348
Advantage: 58

Hangzhou Qianhui Biotechnology Co., LTD

Tel: 0571-16680502907 16680502907
Email: 640280132@qq.com
Country: China
ProdList: 794
Advantage: 58

Hefei Huana Biomedical Technology Co.,Ltd

Tel: 17333066501
Email: shengwen.fang@huanaok.com.cn
Country: China
ProdList: 95
Advantage: 58

Hangzhou Huiyi Biotechnology Co., LTD

Tel: 0571-89918262 13357170655
Email: chenlingwei@hizyme.com
Country: China
ProdList: 264
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Hongene Biotech Corporation

Tel: 021-64757213
Fax: 86-21-64700613
Email: info@hongene.com
Country: China
ProdList: 672
Advantage: 61

More

Less

View Lastest Price from 2'-Deoxy-2'-fluoroguanosine manufacturers

Yunbio Tech Co.,Ltd.

Product: 2'-Deoxy-2'-fluoroguanosine 78842-13-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 300KGS
Release date: 2023-03-04

Hefei Huana Biomedical Technology Co.,Ltd.

Product: 2'-Deoxy-2'-fluoroguanosine 78842-13-4
Price: US $0.00/g
Min. Order: 100g
Purity: ≥98%(HPLC)
Supply Ability: 20t
Release date: 2023-05-11

Zhejiang Hengkang Pharmaceutical Co., Ltd.

Product: 2'-Deoxy-2'-fluoroguanosine 78842-13-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg per month
Release date: 2022-12-27

78842-13-4, 2'-Deoxy-2'-fluoroguanosineRelated Search:

Acyclovir Guanosine Guanosine 5'-monophosphate disodium salt 5'-Guanylic acid Floxuridine FDG 2'-Deoxy-2'-fluoroguanosine

2'-deoxy-2'-fluoroguanosine

2'-FdG

2'-Fluoro -2'-deoxyguanosine

2'-F-2'-dG

Guanosine,2'-deoxy-2'-fluoro-

2-amino-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

2'-Deoxy-2'-fluoroguanosine USP/EP/BP

2'-F-G

2'-F-2'-deoxyguanosine

nucleoside,strains,tract,Influenza Virus,Inhibitor,analog,fever,nasal,inhibit,virus,influenza,upper,2′Deoxy2′fluoroguanosine,2′ Deoxy 2′ fluoroguanosine,respiratory,inflammation

2-Amino-9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one

Guanosine Impurity 9

2'-Fluoro-2'-Deoxyguanosine (FdG)

2'-Fluoro-2'-deoxyguanosine

2'-Deoxy-2'-fluoroguanosine

78842-13-4

78842-23-4

Nucleosides

Modified（deoxy）nucleoside