Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). Property

Boiling point:

383.99°C (rough estimate)

Density 

1.2650 (rough estimate)

refractive index 

1.5300 (estimate)

storage temp. 

-20°C

solubility 

DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 1 mg/ml

form 

A crystalline solid

pka

10.70±0.40(Predicted)

color 

Off-white to gray

EPA Substance Registry System

2-(1-Oxo-2-isoindolinyl)glutarimide (26581-81-7)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). Chemical Properties,Usage,Production

Description

Phthalimidine, 2-(2,6-dioxopiperiden-3-yl) is a lenalidomide analog that can be useful in PROTAC research.

General Description

White crystalline powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). is an example of an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). emits toxic fumes of nitrogen oxides.

Fire Hazard

Flash point data for Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). are not available; however, Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). is probably combustible.