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(-)-THALIDOMIDE

Product Name
(-)-THALIDOMIDE
CAS No.
841-67-8
Chemical Name
(-)-THALIDOMIDE
Synonyms
NSC 91730;(–)-Thalidomide;(-)-THALIDOMIDE;(S)-(-)-THALIDOMIDE;Thalidomide (S)-Isomer;(S)Thalidomide,(S) Thalidomide;6-dioxo-3-piperidyl)-n-(l-(-)-phthalimid;N-[(S)-2,6-Dioxopiperidine-3-yl]phthalimide;(-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN;(-)-N-[(S)-2,6-Dioxo-3-piperidinyl]phthalimide
CBNumber
CB5762707
Molecular Formula
C13H10N2O4
Formula Weight
258.23
MOL File
841-67-8.mol
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(-)-THALIDOMIDE Property

Melting point:
269-271°C
Boiling point:
401.48°C (rough estimate)
Density 
1.2944 (rough estimate)
refractive index 
1.5300 (estimate)
storage temp. 
-20°C Freezer
solubility 
DMSO: soluble
form 
solid
pka
10.70±0.40(Predicted)
color 
white
optical activity
[α]23/D 62.6°, c = 2 in DMF(lit.)
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Safety

Hazard Codes 
T
Risk Statements 
61-22
Safety Statements 
53-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
TI4925050
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T150
Product name
(?)-Thalidomide
Purity
>98%, solid
Packaging
10mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
T150
Product name
(?)-Thalidomide
Purity
>98%, solid
Packaging
25mg
Price
$271
Updated
2024/03/01
Sigma-Aldrich
Product number
T150
Product name
(?)-Thalidomide
Purity
>98%, solid
Packaging
100mg
Price
$762
Updated
2024/03/01
TRC
Product number
T338860
Product name
(S)-(-)-Thalidomide
Packaging
50mg
Price
$400
Updated
2021/12/16
TRC
Product number
T338860
Product name
(S)-(-)-Thalidomide
Packaging
100mg
Price
$725
Updated
2021/12/16
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(-)-THALIDOMIDE Chemical Properties,Usage,Production

Chemical Properties

Needles

Uses

Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative

Uses

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.

Definition

ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has S-configuration at the chiral centre.

General Description

Thalidomide is a stereoisomer, which exists in two enantiomeric states. The S enantiomer is teratogenic. Thalidomide consists of two linked rings, a phthalimide and glutarimide ring.

Biochem/physiol Actions

(-)-Thalidomide selectively inhibits the biosynthesis of tumor necrosis factor α (TNF-α), which is essential for inflammatory response. It is an anti-emetic drug and is used to treat morning sickness in pregnant women. Thalidomide is also used to treat leprosy, multiple myeloma, Crohn′s disease and human immunodeficiency virus (HIV) infection. Thalidomide also inhibits angiogenesis. It is associated with several diseases such as, peripheral neuropathy, facial palsies, Duane syndrome and autism.

(-)-THALIDOMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-THALIDOMIDE Suppliers

ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai Chiral bio-compound co., Ltd.
Tel
021-5068 3667/17749785980/1029026415; 17749785980
Fax
021-50683667
Email
1029026415@qq.com
Country
China
ProdList
3013
Advantage
58
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View Lastest Price from (-)-THALIDOMIDE manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
(S)-thalidomide 841-67-8
Price
US $0.00/mg
Min. Order
25mg
Purity
>99.00%
Supply Ability
25mg
Release date
2024-04-01

841-67-8, (-)-THALIDOMIDERelated Search:


  • 6-dioxo-3-piperidinyl)-3(2h)-dion(s)-1h-isoindole-2-(2
  • 6-dioxo-3-piperidyl)-n-(l-(-)-phthalimid
  • (S)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE
  • S(-)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE
  • (S)-(-)-THALIDOMIDE
  • (-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN
  • (-)-N-[(S)-2,6-Dioxo-3-piperidinyl]phthalimide
  • (3S)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
  • 2-[(3S)-2,6-Dioxo-3-piperidyl]-1H-isoindole-1,3(2H)-dione
  • N-[(S)-2,6-Dioxopiperidine-3-yl]phthalimide
  • NSC 91730
  • Thalidomide (S)-Isomer
  • 1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-
  • (–)-Thalidomide
  • (-)-THALIDOMIDE
  • (S)Thalidomide,(S) Thalidomide
  • (2r)-2,3-bis[(4,4-difluorotetradecanoyl)oxy]propyl 2-(trimethylammonio)ethyl phosphate
  • Ibuprofen Impurity 13 (Ibuprofen EP Impurity M Sodium salt)
  • 841-67-8
  • Cytoskeleton and Extracellular Matrix
  • Extracellular Matrix
  • Angiogenesis Regulators
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals