(-)-THALIDOMIDE
- Product Name
- (-)-THALIDOMIDE
- CAS No.
- 841-67-8
- Chemical Name
- (-)-THALIDOMIDE
- Synonyms
- NSC 91730;(–)-Thalidomide;(-)-THALIDOMIDE;(S)-(-)-THALIDOMIDE;Thalidomide (S)-Isomer;(S)Thalidomide,(S) Thalidomide;6-dioxo-3-piperidyl)-n-(l-(-)-phthalimid;N-[(S)-2,6-Dioxopiperidine-3-yl]phthalimide;(-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN;(-)-N-[(S)-2,6-Dioxo-3-piperidinyl]phthalimide
- CBNumber
- CB5762707
- Molecular Formula
- C13H10N2O4
- Formula Weight
- 258.23
- MOL File
- 841-67-8.mol
(-)-THALIDOMIDE Property
- Melting point:
- 269-271°C
- Boiling point:
- 401.48°C (rough estimate)
- Density
- 1.2944 (rough estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- DMSO: soluble
- form
- solid
- pka
- 10.70±0.40(Predicted)
- color
- white
- optical activity
- [α]23/D 62.6°, c = 2 in DMF(lit.)
Safety
- Hazard Codes
- T
- Risk Statements
- 61-22
- Safety Statements
- 53-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- TI4925050
N-Bromosuccinimide Price
- Product number
- T150
- Product name
- (?)-Thalidomide
- Purity
- >98%, solid
- Packaging
- 10mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- T150
- Product name
- (?)-Thalidomide
- Purity
- >98%, solid
- Packaging
- 25mg
- Price
- $271
- Updated
- 2024/03/01
- Product number
- T150
- Product name
- (?)-Thalidomide
- Purity
- >98%, solid
- Packaging
- 100mg
- Price
- $762
- Updated
- 2024/03/01
- Product number
- T338860
- Product name
- (S)-(-)-Thalidomide
- Packaging
- 100mg
- Price
- $725
- Updated
- 2021/12/16
- Product number
- T338860
- Product name
- (S)-(-)-Thalidomide
- Packaging
- 50mg
- Price
- $400
- Updated
- 2021/12/16
(-)-THALIDOMIDE Chemical Properties,Usage,Production
Chemical Properties
Needles
Uses
Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative
Uses
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.
Definition
ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has S-configuration at the chiral centre.
General Description
Thalidomide is a stereoisomer, which exists in two enantiomeric states. The S enantiomer is teratogenic. Thalidomide consists of two linked rings, a phthalimide and glutarimide ring.
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits the biosynthesis of tumor necrosis factor α (TNF-α), which is essential for inflammatory response. It is an anti-emetic drug and is used to treat morning sickness in pregnant women. Thalidomide is also used to treat leprosy, multiple myeloma, Crohn′s disease and human immunodeficiency virus (HIV) infection. Thalidomide also inhibits angiogenesis. It is associated with several diseases such as, peripheral neuropathy, facial palsies, Duane syndrome and autism.
(-)-THALIDOMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(-)-THALIDOMIDE Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
View Lastest Price from (-)-THALIDOMIDE manufacturers
- Product
- (S)-thalidomide 841-67-8
- Price
- US $0.00/mg
- Min. Order
- 25mg
- Purity
- >99.00%
- Supply Ability
- 25mg
- Release date
- 2024-04-01