(-)-THALIDOMIDE

Product Name: (-)-THALIDOMIDE
CAS No.: 841-67-8
Chemical Name: (-)-THALIDOMIDE
Synonyms: NSC 91730;(–)-Thalidomide;(-)-THALIDOMIDE;(S)-(-)-THALIDOMIDE;Thalidomide (S)-Isomer;(S)Thalidomide,(S) Thalidomide;6-dioxo-3-piperidyl)-n-(l-(-)-phthalimid;N-[(S)-2,6-Dioxopiperidine-3-yl]phthalimide;(-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN;(-)-N-[(S)-2,6-Dioxo-3-piperidinyl]phthalimide
CBNumber: CB5762707
Molecular Formula: C13H10N2O4
Formula Weight: 258.23
MOL File: 841-67-8.mol

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(-)-THALIDOMIDE Property

Melting point:: 269-271°C
Boiling point:: 401.48°C (rough estimate)
Density: 1.2944 (rough estimate)
refractive index: 1.5300 (estimate)
storage temp.: -20°C Freezer
solubility: DMSO: soluble
form: solid
pka: 10.70±0.40(Predicted)
color: white
optical activity: [α]23/D 62.6°, c = 2 in DMF(lit.)

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Safety

Hazard Codes: T
Risk Statements: 61-22
Safety Statements: 53-36/37/39-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: TI4925050

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T150
Product name: (?)-Thalidomide
Purity: >98%, solid
Packaging: 10mg
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: T150
Product name: (?)-Thalidomide
Purity: >98%, solid
Packaging: 25mg
Price: $271
Updated: 2024/03/01

Sigma-Aldrich

Product number: T150
Product name: (?)-Thalidomide
Purity: >98%, solid
Packaging: 100mg
Price: $762
Updated: 2024/03/01

TRC

Product number: T338860
Product name: (S)-(-)-Thalidomide
Packaging: 100mg
Price: $725
Updated: 2021/12/16

TRC

Product number: T338860
Product name: (S)-(-)-Thalidomide
Packaging: 50mg
Price: $400
Updated: 2021/12/16

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(-)-THALIDOMIDE Chemical Properties,Usage,Production

Chemical Properties

Needles

Uses

Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative

Uses

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.

Definition

ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has S-configuration at the chiral centre.

General Description

Thalidomide is a stereoisomer, which exists in two enantiomeric states. The S enantiomer is teratogenic. Thalidomide consists of two linked rings, a phthalimide and glutarimide ring.

Biochem/physiol Actions

(-)-Thalidomide selectively inhibits the biosynthesis of tumor necrosis factor α (TNF-α), which is essential for inflammatory response. It is an anti-emetic drug and is used to treat morning sickness in pregnant women. Thalidomide is also used to treat leprosy, multiple myeloma, Crohn′s disease and human immunodeficiency virus (HIV) infection. Thalidomide also inhibits angiogenesis. It is associated with several diseases such as, peripheral neuropathy, facial palsies, Duane syndrome and autism.

(-)-THALIDOMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-THALIDOMIDE Suppliers

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View Lastest Price from (-)-THALIDOMIDE manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S)-thalidomide 841-67-8
Price: US $0.00/mg
Min. Order: 25mg
Purity: >99.00%
Supply Ability: 25mg
Release date: 2024-04-01

841-67-8, (-)-THALIDOMIDERelated Search:

Thalidomide 3-DIMETHYLAMINOPIPERIDINE Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). N-(2-AMINO-ETHYL)-PHTHALIMIDE 5'-HYDROXY THALIDOMIDE 3-(N-ACETYL-N-METHYLAMINO)PIPERIDINE (S)-3-AMINOPIPERIDINE-2-ONE (S)-3-Aminopiperidine N-(piperidin-3-yl)benzamide 3-AMINOPIPERIDINE (-)-THALIDOMIDE 3-amino-2-Piperidinone 3-ACETAMIDOPIPERIDINE (S)-A-PHTHALIMIDOPROPIONALDEHYDE

6-dioxo-3-piperidinyl)-3(2h)-dion(s)-1h-isoindole-2-(2

6-dioxo-3-piperidyl)-n-(l-(-)-phthalimid

(S)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE

S(-)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE

(S)-(-)-THALIDOMIDE

(-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN

(-)-N-[(S)-2,6-Dioxo-3-piperidinyl]phthalimide

(3S)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione

2-[(3S)-2,6-Dioxo-3-piperidyl]-1H-isoindole-1,3(2H)-dione

N-[(S)-2,6-Dioxopiperidine-3-yl]phthalimide

NSC 91730

Thalidomide (S)-Isomer

1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-

(–)-Thalidomide

(-)-THALIDOMIDE

(S)Thalidomide,(S) Thalidomide

(2r)-2,3-bis[(4,4-difluorotetradecanoyl)oxy]propyl 2-(trimethylammonio)ethyl phosphate

Ibuprofen Impurity 13 (Ibuprofen EP Impurity M Sodium salt)

841-67-8

Cytoskeleton and Extracellular Matrix

Extracellular Matrix

Angiogenesis Regulators

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals