[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

ChemicalBook > CAS DataBase List > [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

Product Name: [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
CAS No.: 5428-80-8
Chemical Name: [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
Synonyms: Vacquinol-1;CS-2185;NSC13316;NSC 13316;NSC-13316;Vacquinol-1（NSC13316）;NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol;4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
CBNumber: CB51254607
Molecular Formula: C21H21ClN2O
Formula Weight: 352.86
MOL File: 5428-80-8.mol

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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Property

Melting point:: 198-199.5 °C
Boiling point:: 551.4±50.0 °C(Predicted)
Density: 1.244±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
form: A crystalline solid
pka: 13.22±0.20(Predicted)

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16321
Product name: Vacquinol-1
Purity: ≥98%
Packaging: 1mg
Price: $51
Updated: 2024/03/01

Cayman Chemical

Product number: 16321
Product name: Vacquinol-1
Purity: ≥98%
Packaging: 5mg
Price: $140
Updated: 2024/03/01

Cayman Chemical

Product number: 16321
Product name: Vacquinol-1
Purity: ≥98%
Packaging: 10mg
Price: $253
Updated: 2024/03/01

Cayman Chemical

Product number: 16321
Product name: Vacquinol-1
Purity: ≥98%
Packaging: 25mg
Price: $569
Updated: 2024/03/01

Usbiological

Product number: 468532
Product name: Vacquinol-1
Packaging: 1mg
Price: $319
Updated: 2021/12/16

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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties,Usage,Production

Description

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC₅₀ = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

Uses

Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol manufacturers

Career Henan Chemical Co

Product: Vacquinol-1 5428-80-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

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