Valspodar
- Product Name
- Valspodar
- CAS No.
- 121584-18-7
- Chemical Name
- Valspodar
- Synonyms
- Psc 833;CS-51;AMdray;Valpodar;Valspodar;Sdz-psc-833;Sdz psc 833;Valspodar, >=98%;PSC833(Valspodar);Valspodar (PSC-833)
- CBNumber
- CB71116624
- Molecular Formula
- C63H111N11O12
- Formula Weight
- 1214.62
- MOL File
- 121584-18-7.mol
Valspodar Property
- Melting point:
- 143-145°C
- Boiling point:
- 1290.1±65.0 °C(Predicted)
- alpha
- D20 -255.1° (c = 0.5 in CHCl3)
- Density
- 1.015±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- powder
- pka
- 12.45±0.70(Predicted)
- color
- white to beige
- InChIKey
- YJDYDFNKCBANTM-QCWCSKBGSA-N
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0572
- Product name
- Valspodar
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $189
- Updated
- 2024/03/01
- Product number
- SML0572
- Product name
- Valspodar
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $741
- Updated
- 2024/03/01
- Product number
- 20391
- Product name
- PSC 833
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 20391
- Product name
- PSC 833
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $55
- Updated
- 2024/03/01
- Product number
- 20391
- Product name
- PSC 833
- Purity
- ≥95%
- Packaging
- 5 mg
- Price
- $184
- Updated
- 2024/03/01
Valspodar Chemical Properties,Usage,Production
Description
PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.
Chemical Properties
White Solid
Uses
Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.
Uses
Valspodar(PSC-833), a 2nd-generation ABC transporter inhibitor, limits HCMV infection as demonstrated by the decrease in IE2 expression of virus-infected cells. As a cyclosporin D analog, it has been shown to be a much more effective inhibitor of MDR than cyclosporin A and to be less toxic[1-2].
Uses
Antineoplastic adjunct (chemosensitizer).
Definition
ChEBI: SDZ PSC 833 is a homodetic cyclic peptide.
brand name
Amdray (Novartis).
Biochem/physiol Actions
Valspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.
Cytotoxicity
Cells treated with increasing concentrations of valspodar over a 9-day period show minimal cytotoxicity. It appears to be neither immunosuppressive nor nephrotoxic with the ability to achieve levels in the blood (1 μm) capable of reversing drug resistance without excessive toxicity[1].
storage
Store at -20°C
References
[1] Friedenberg W, et al. Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95). Cancer, 2006; 106: 830-838.
[2] Parsons J, et al. Valspodar limits human cytomegalovirus infection and dissemination. Antiviral Research, 2021; 193: 105124.
Valspodar Preparation Products And Raw materials
Raw materials
Preparation Products
Valspodar Suppliers
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- China
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- (86) 21-58955996
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- Country
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View Lastest Price from Valspodar manufacturers
- Product
- Valspodar 121584-18-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Valspodar 121584-18-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09