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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

Product Name
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
CAS No.
5428-80-8
Chemical Name
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
Synonyms
Vacquinol-1;CS-2185;NSC13316;NSC 13316;NSC-13316;Vacquinol-1（NSC13316）;Vacquinol-1 dihydrochloride;NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
CBNumber
CB51254607
Molecular Formula
C21H21ClN2O
Formula Weight
352.86
MOL File
5428-80-8.mol
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Property

Melting point:
198-199.5 °C
Boiling point:
551.4±50.0 °C(Predicted)
Density 
1.244±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.25 mg/ml
form 
A crystalline solid
pka
13.22±0.20(Predicted)
color 
white to beige
InChI
1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2
InChIKey
VKLJPGAHSLIQKH-UHFFFAOYSA-N
SMILES
Clc1ccc(cc1)c2nc3c(c(c2)C(O)C4NCCCC4)cccc3
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Safety

WGK Germany 
WGK 3
HS Code 
2933499090
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1187
Product name
Vacquinol-1 dihydrochloride
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$138
Updated
2026/03/19
Cayman Chemical
Product number
16321
Product name
Vacquinol-1
Purity
≥98%
Packaging
1mg
Price
$51
Updated
2024/03/01
Cayman Chemical
Product number
16321
Product name
Vacquinol-1
Purity
≥98%
Packaging
5mg
Price
$140
Updated
2024/03/01
Cayman Chemical
Product number
16321
Product name
Vacquinol-1
Purity
≥98%
Packaging
10mg
Price
$253
Updated
2024/03/01
Cayman Chemical
Product number
16321
Product name
Vacquinol-1
Purity
≥98%
Packaging
25mg
Price
$569
Updated
2024/03/01
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties,Usage,Production

Description

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

Uses

Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

References

[1] SATISH SRINIVAS KITAMBI. RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.[J]. Cell, 2014, 157 2: 313-328. DOI: 10.1016/j.cell.2014.02.021

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Suppliers

China 74 United States 8 Global 82
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1876
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55
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
40000
Advantage
60
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3291
Advantage
58
Aishilun biotechnology (Shanghai) co., LTD
Tel
021-50676523 18019098996
Email
info@acelybio.com
Country
China
ProdList
3960
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
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View Lastest Price from [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol manufacturers

Career Henan Chemical Co
Product
Vacquinol-1 5428-80-8
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

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