ChemicalBook > CAS DataBase List > [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

Product Name
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
CAS No.
5428-80-8
Chemical Name
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
Synonyms
Vacquinol-1;CS-2185;NSC13316;NSC 13316;NSC-13316;Vacquinol-1(NSC13316);NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1;4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-;[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol;4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
CBNumber
CB51254607
Molecular Formula
C21H21ClN2O
Formula Weight
352.86
MOL File
5428-80-8.mol
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Property

Melting point:
198-199.5 °C
Boiling point:
551.4±50.0 °C(Predicted)
Density 
1.244±0.06 g/cm3(Predicted)
pka
13.22±0.20(Predicted)
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16321
Product name
Vacquinol-1
Purity
≥98%
Packaging
1mg
Price
$45
Updated
2023/01/06
Cayman Chemical
Product number
16321
Product name
Vacquinol-1
Purity
≥98%
Packaging
5mg
Price
$124
Updated
2023/01/06
Cayman Chemical
Product number
16321
Product name
Vacquinol-1
Purity
≥98%
Packaging
10mg
Price
$225
Updated
2023/01/06
Cayman Chemical
Product number
16321
Product name
Vacquinol-1
Purity
≥98%
Packaging
25mg
Price
$506
Updated
2023/01/06
Usbiological
Product number
468532
Product name
Vacquinol-1
Packaging
1mg
Price
$319
Updated
2021/12/16
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties,Usage,Production

Description

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

Uses

Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Suppliers

EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1992
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
3004
Advantage
60
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
Country
China
ProdList
3016
Advantage
50
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696 15000506266
Fax
+86-21-52996696
Email
2311958233@qq.com
Country
China
ProdList
3451
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
132094
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3155
Advantage
58
Aishilun biotechnology (Shanghai) co., LTD
Tel
021-50676523 18019098996
Email
info@acelybio.com
Country
China
ProdList
3968
Advantage
58
Henan Alfa Chemical Co., Ltd
Tel
+8618339805032
Email
alfa4@alfachem.cn
Country
China
ProdList
14275
Advantage
58
InvivoChem
Tel
+1-708-3101919
Fax
708-557-7486
Email
sales@invivochem.net
Country
United States
ProdList
6395
Advantage
58
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View Lastest Price from [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol manufacturers

Career Henan Chemical Co
Product
Vacquinol-1 5428-80-8
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

5428-80-8, [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanolRelated Search:


  • [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
  • 4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-
  • Vacquinol-1
  • NSC 13316
  • NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1
  • NSC13316
  • NSC-13316
  • CS-2185
  • 4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-
  • Vacquinol-1(NSC13316)
  • 5428-80-8
  • C21H23Cl3N2O
  • building block