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ALK5 inhibitor II

Product Name
ALK5 inhibitor II
CAS No.
446859-33-2
Chemical Name
ALK5 inhibitor II
Synonyms
RepSox;E-616452;CS-204;E616452;E 616452;SJN 2511;RepSox, >=98%;RepSox(E-616452;ALK5 INHIBITOR I;ALK5 Inhibitor II
CBNumber
CB3806232
Molecular Formula
C17H13N5
Formula Weight
287.32
MOL File
Mol file
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ALK5 inhibitor II Property

Melting point:
195 °C
Boiling point:
501.9±50.0 °C(Predicted)
Density 
1.296±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
Yellow solid
pka
10.05±0.50(Predicted)
color 
Pale yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey
LBPKYPYHDKKRFS-UHFFFAOYSA-N
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R0158
Product name
RepSox
Purity
≥98% (HPLC)
Packaging
5mg
Price
$131
Updated
2023/01/07
Sigma-Aldrich
Product number
R0158
Product name
RepSox
Purity
≥98% (HPLC)
Packaging
25mg
Price
$551
Updated
2023/01/07
Sigma-Aldrich
Product number
5.08158
Product name
InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem
Packaging
5mg
Price
$123
Updated
2023/01/07
TCI Chemical
Product number
R0224
Product name
RepSox
Packaging
5MG
Price
$85
Updated
2023/01/07
TCI Chemical
Product number
R0224
Product name
RepSox
Packaging
25MG
Price
$264
Updated
2023/01/07
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ALK5 inhibitor II Chemical Properties,Usage,Production

Description

RepSox (446859-33-2) is a potent (IC50?ALK5 auto-P= 4 nM; IC50?TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1?RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2?It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4

Uses

Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.

Uses

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

Biochem/physiol Actions

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

References

1) Gellibert?et al. (2004),?Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J. Med. Chem.?47?4494 2) Ichida?et al.?(2009),?A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell?5?491 3) Cheng?et al.?(2015),?Direct Conversion of astrocytes into neuronal cells by a drug cocktail;?Cell Res.?25?1269 4) Cheng?et al.?(2014),?Generation of neural progenitor cells by chemical cocktails and hypoxia; Cell Res.?24?665

ALK5 inhibitor II Preparation Products And Raw materials

Raw materials

Preparation Products

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ALK5 inhibitor II Suppliers

Changzhou Fulangke Chemical Technology Co., Ltd.
Tel
13776872728
Email
amwpl888@sina.cn
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China
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58
Shanghai Enong Biotechnology Co., LTD
Tel
15821616017
Email
SARA@AGRIGE.COM
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China
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49
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58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
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55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96427
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15861
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Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
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6005
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VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
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United States
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510
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Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
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1856
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Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
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4271
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65
Shanghai SynFarm Pharmaceutical Technology Co., Ltd.
Tel
021-50793966 18917198199
Fax
+86-21-50793967
Email
info@synfarm.com
Country
China
ProdList
276
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58
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View Lastest Price from ALK5 inhibitor II manufacturers

Career Henan Chemical Co
Product
2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE 446859-33-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

446859-33-2, ALK5 inhibitor IIRelated Search:


  • ALK5 INHIBITOR I
  • 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE
  • 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
  • SJN 2511
  • 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • E 616452
  • E616452
  • E-616452
  • ALK5 Inhibitor II
  • 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
  • RepSox 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • RepSox, >=98%
  • RepSox(E-616452
  • TGF-BETA RI KINASE INHIBITOR II
  • TRANSFORMING GROWTH FACTOR-BETA TYPE I RECEPTOR KINASE INHIBITOR I
  • RepSox
  • RepSox(ALK5 Inhibitor II)
  • TGF-β RI Kinase Inhibitor II
  • RepSox (SJN 2511)
  • E-616452;SJN 2511;ALK5 INHIBITOR II;TGF-&BETA RI KINASE INHIBITOR II
  • TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem
  • InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem
  • E-616452; SJN 2511; E616452; SJN2511; E 616452; SJN-2511
  • CS-204
  • 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • 446859-33-2
  • Selective inhibitor of the TGF-β type I receptor ALK5.
  • Smad
  • TGF-beta
  • Inhibitors