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ALK5 inhibitor II

Product Name
ALK5 inhibitor II
CAS No.
446859-33-2
Chemical Name
ALK5 inhibitor II
Synonyms
RepSox;E-616452;CS-204;E616452;E 616452;SJN 2511;RepSox, >=98%;RepSox(E-616452;ALK5 INHIBITOR I;ALK5 Inhibitor II
CBNumber
CB3806232
Molecular Formula
C17H13N5
Formula Weight
287.32
MOL File
Mol file
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ALK5 inhibitor II Property

Melting point:
195 °C
Boiling point:
501.9±50.0 °C(Predicted)
Density 
1.296±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
Yellow solid
pka
10.05±0.50(Predicted)
color 
Pale yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey
LBPKYPYHDKKRFS-UHFFFAOYSA-N
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R0158
Product name
RepSox
Purity
≥98% (HPLC)
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
R0158
Product name
RepSox
Purity
≥98% (HPLC)
Packaging
25mg
Price
$565
Updated
2024/03/01
Sigma-Aldrich
Product number
5.08158
Product name
InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem
Packaging
5mg
Price
$126
Updated
2024/03/01
TCI Chemical
Product number
R0224
Product name
RepSox
Packaging
5MG
Price
$68
Updated
2024/03/01
TCI Chemical
Product number
R0224
Product name
RepSox
Packaging
25MG
Price
$211
Updated
2024/03/01
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ALK5 inhibitor II Chemical Properties,Usage,Production

Description

RepSox (446859-33-2) is a potent (IC50?ALK5 auto-P= 4 nM; IC50?TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1?RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2?It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4

Uses

Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.

Uses

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

Definition

ChEBI: 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- is a pyrazolopyridine.

Biochem/physiol Actions

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

storage

+4°C

References

1) Gellibert?et al. (2004),?Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J. Med. Chem.?47?4494 2) Ichida?et al.?(2009),?A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell?5?491 3) Cheng?et al.?(2015),?Direct Conversion of astrocytes into neuronal cells by a drug cocktail;?Cell Res.?25?1269 4) Cheng?et al.?(2014),?Generation of neural progenitor cells by chemical cocktails and hypoxia; Cell Res.?24?665

ALK5 inhibitor II Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ALK5 inhibitor II manufacturers

Career Henan Chemical Co
Product
2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE 446859-33-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

446859-33-2, ALK5 inhibitor IIRelated Search:


  • ALK5 INHIBITOR I
  • 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE
  • 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
  • SJN 2511
  • 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • E 616452
  • E616452
  • E-616452
  • ALK5 Inhibitor II
  • 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
  • RepSox 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • RepSox, >=98%
  • RepSox(E-616452
  • TGF-BETA RI KINASE INHIBITOR II
  • TRANSFORMING GROWTH FACTOR-BETA TYPE I RECEPTOR KINASE INHIBITOR I
  • RepSox
  • RepSox(ALK5 Inhibitor II)
  • TGF-β RI Kinase Inhibitor II
  • RepSox (SJN 2511)
  • E-616452;SJN 2511;ALK5 INHIBITOR II;TGF-&BETA RI KINASE INHIBITOR II
  • TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem
  • InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem
  • E-616452; SJN 2511; E616452; SJN2511; E 616452; SJN-2511
  • CS-204
  • 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
  • 446859-33-2
  • Selective inhibitor of the TGF-β type I receptor ALK5.
  • Smad
  • TGF-beta
  • Inhibitors