ALK5 inhibitor II

Product Name: ALK5 inhibitor II
CAS No.: 446859-33-2
Chemical Name: ALK5 inhibitor II
Synonyms: RepSox;E-616452;CS-204;E616452;E 616452;SJN 2511;RepSox, >=98%;RepSox(E-616452;ALK5 INHIBITOR I;ALK5 Inhibitor II
CBNumber: CB3806232
Molecular Formula: C17H13N5
Formula Weight: 287.32
MOL File: Mol file

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ALK5 inhibitor II Property

Melting point:: 195 °C
Boiling point:: 501.9±50.0 °C(Predicted)
Density: 1.296±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: Yellow solid
pka: 10.05±0.50(Predicted)
color: Pale yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey: LBPKYPYHDKKRFS-UHFFFAOYSA-N

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R0158
Product name: RepSox
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: R0158
Product name: RepSox
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $565
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.08158
Product name: InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem
Packaging: 5mg
Price: $126
Updated: 2024/03/01

TCI Chemical

Product number: R0224
Product name: RepSox
Packaging: 5MG
Price: $68
Updated: 2024/03/01

TCI Chemical

Product number: R0224
Product name: RepSox
Packaging: 25MG
Price: $211
Updated: 2024/03/01

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ALK5 inhibitor II Chemical Properties,Usage,Production

Description

RepSox (446859-33-2) is a potent (IC50?ALK5 auto-P= 4 nM; IC50?TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1?RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2?It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4

Uses

Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.

Uses

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

Definition

ChEBI: 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- is a pyrazolopyridine.

Biochem/physiol Actions

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

storage

+4°C

References

1) Gellibert?et al. (2004),?Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J. Med. Chem.?47?4494 2) Ichida?et al.?(2009),?A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell?5?491 3) Cheng?et al.?(2015),?Direct Conversion of astrocytes into neuronal cells by a drug cocktail;?Cell Res.?25?1269 4) Cheng?et al.?(2014),?Generation of neural progenitor cells by chemical cocktails and hypoxia; Cell Res.?24?665

ALK5 inhibitor II Preparation Products And Raw materials

Raw materials

Preparation Products

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ALK5 inhibitor II Suppliers

Canada 1 China 152 India 4 Japan 1 Switzerland 1 United Kingdom 2 United States 21 Global 182

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Shanghai Ennopharm Co., Ltd.

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View Lastest Price from ALK5 inhibitor II manufacturers

Career Henan Chemical Co

Product: 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE 446859-33-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

446859-33-2, ALK5 inhibitor IIRelated Search:

TYRPHOSTIN AG 1296 ZM 336372 ZM 306416 hydrochloride SU 4312 DADEPYLIPQQG PF 543 Valspodar PF-543 (Citrate) Y27632 (hydrochloride) SB 431542 LY2109761 SB525334 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- CHIR-99021

ALK5 INHIBITOR I

2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE

2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

SJN 2511

2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine

E 616452

E616452

E-616452

ALK5 Inhibitor II

1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-

RepSox 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine

RepSox, >=98%

RepSox(E-616452

TGF-BETA RI KINASE INHIBITOR II

TRANSFORMING GROWTH FACTOR-BETA TYPE I RECEPTOR KINASE INHIBITOR I

RepSox

RepSox(ALK5 Inhibitor II)

TGF-β RI Kinase Inhibitor II

RepSox (SJN 2511)

E-616452;SJN 2511;ALK5 INHIBITOR II;TGF-&BETA RI KINASE INHIBITOR II

TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem

E-616452; SJN 2511; E616452; SJN2511; E 616452; SJN-2511

CS-204

2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine

446859-33-2

Selective inhibitor of the TGF-β type I receptor ALK5.

Smad

TGF-beta

Inhibitors