ChemicalBook > CAS DataBase List > ALK5 inhibitor II

ALK5 inhibitor II

Product Name: ALK5 inhibitor II
CAS No.: 446859-33-2
Chemical Name: ALK5 inhibitor II
Synonyms: RepSox;E-616452;CS-204;E616452;E 616452;SJN 2511;RepSox, >=98%;RepSox(E-616452;ALK5 INHIBITOR I;ALK5 Inhibitor II
CBNumber: CB3806232
Molecular Formula: C17H13N5
Formula Weight: 287.32
MOL File: Mol file

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ALK5 inhibitor II Property

Melting point:: 195 °C
Boiling point:: 501.9±50.0 °C(Predicted)
Density: 1.296±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: Yellow solid
pka: 10.05±0.50(Predicted)
color: Pale yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChIKey: LBPKYPYHDKKRFS-UHFFFAOYSA-N
SMILES: N1C2C(=NC=CC=2)C=CC=1C1=CNN=C1C1=NC(C)=CC=C1

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R0158
Product name: RepSox
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $138
Updated: 2025/07/31

Sigma-Aldrich

Product number: R0158
Product name: RepSox
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $581
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.08158
Product name: InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem
Packaging: 5mg
Price: $111
Updated: 2025/07/31

TCI Chemical

Product number: R0224
Product name: RepSox
Packaging: 5MG
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: R0224
Product name: RepSox
Packaging: 25MG
Price: $190
Updated: 2025/07/31

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ALK5 inhibitor II Chemical Properties,Usage,Production

Description

RepSox (446859-33-2) is a potent (IC50?ALK5 auto-P= 4 nM; IC50?TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1?RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2?It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4

Uses

Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.

Uses

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

Definition

ChEBI: 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- is a pyrazolopyridine.

Biochem/physiol Actions

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

storage

+4°C

References

[1] FRANÇOISE GELLIBERT. Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors[J]. Journal of Medicinal Chemistry, 2004, 47 18: 4494-4506. DOI:10.1021/jm0400247
[2] JUSTIN K ICHIDA. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.[J]. Cell stem cell, 2009, 5 5: 491-503. DOI:10.1016/j.stem.2009.09.012
[3] LIN CHENG. Direct conversion of astrocytes into neuronal cells by drug cocktail[J]. Cell Research, 2015, 25 11: 1269-1272. DOI:10.1038/cr.2015.120
[4] LIN CHENG. Generation of neural progenitor cells by chemical cocktails and hypoxia[J]. Cell Research, 2014, 24 6: 665-679. DOI:10.1038/cr.2014.32

ALK5 inhibitor II Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ALK5 inhibitor II manufacturers

Career Henan Chemical Co

Product: 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE 446859-33-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

446859-33-2, ALK5 inhibitor IIRelated Search:

TYRPHOSTIN AG 1296 ZM 336372 ZM 306416 hydrochloride SU 4312 DADEPYLIPQQG PF 543 Valspodar PF-543 (Citrate) Y27632 (hydrochloride) SB 431542 LY2109761 SB525334 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- CHIR-99021

ALK5 INHIBITOR I

2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE

2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

SJN 2511

2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine

E 616452

E616452

E-616452

ALK5 Inhibitor II

1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-

RepSox 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine

RepSox, >=98%

RepSox(E-616452

TGF-BETA RI KINASE INHIBITOR II

TRANSFORMING GROWTH FACTOR-BETA TYPE I RECEPTOR KINASE INHIBITOR I

RepSox

RepSox(ALK5 Inhibitor II)

TGF-β RI Kinase Inhibitor II

RepSox (SJN 2511)

E-616452;SJN 2511;ALK5 INHIBITOR II;TGF-&BETA RI KINASE INHIBITOR II

TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem

E-616452; SJN 2511; E616452; SJN2511; E 616452; SJN-2511

CS-204

2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine

RepSox, TGF-beta type 1 receptor inhibitor

RepSox, 10 mM in DMSO

TGF-β RI Kinase Inhibitor II

RepSox/446859-33-2/98%

RepSox (E-616452) ，S7223

446859-33-2

Selective inhibitor of the TGF-β type I receptor ALK5.

Smad

TGF-beta

Inhibitors