ALK5 inhibitor II
- Product Name
- ALK5 inhibitor II
- CAS No.
- 446859-33-2
- Chemical Name
- ALK5 inhibitor II
- Synonyms
- RepSox;E-616452;CS-204;E616452;E 616452;SJN 2511;RepSox, >=98%;RepSox(E-616452;ALK5 INHIBITOR I;ALK5 Inhibitor II
- CBNumber
- CB3806232
- Molecular Formula
- C17H13N5
- Formula Weight
- 287.32
- MOL File
- Mol file
ALK5 inhibitor II Property
- Melting point:
- 195 °C
- Boiling point:
- 501.9±50.0 °C(Predicted)
- Density
- 1.296±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- Yellow solid
- pka
- 10.05±0.50(Predicted)
- color
- Pale yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- LBPKYPYHDKKRFS-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- R0158
- Product name
- RepSox
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- R0158
- Product name
- RepSox
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $565
- Updated
- 2024/03/01
- Product number
- 5.08158
- Product name
- InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem
- Packaging
- 5mg
- Price
- $126
- Updated
- 2024/03/01
- Product number
- R0224
- Product name
- RepSox
- Packaging
- 5MG
- Price
- $68
- Updated
- 2024/03/01
- Product number
- R0224
- Product name
- RepSox
- Packaging
- 25MG
- Price
- $211
- Updated
- 2024/03/01
ALK5 inhibitor II Chemical Properties,Usage,Production
Description
RepSox (446859-33-2) is a potent (IC50?ALK5 auto-P= 4 nM; IC50?TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1?RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2?It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4
Uses
Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.
Uses
RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.
Definition
ChEBI: 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- is a pyrazolopyridine.
Biochem/physiol Actions
RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).
storage
+4°C
References
1) Gellibert?et al. (2004),?Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J. Med. Chem.?47?4494 2) Ichida?et al.?(2009),?A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell?5?491 3) Cheng?et al.?(2015),?Direct Conversion of astrocytes into neuronal cells by a drug cocktail;?Cell Res.?25?1269 4) Cheng?et al.?(2014),?Generation of neural progenitor cells by chemical cocktails and hypoxia; Cell Res.?24?665
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View Lastest Price from ALK5 inhibitor II manufacturers
- Product
- 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE 446859-33-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04