(4-Bromophenyl)(pyrrolidin-1-yl)methanone

Product Name: (4-Bromophenyl)(pyrrolidin-1-yl)methanone
CAS No.: 5543-27-1
Chemical Name: (4-Bromophenyl)(pyrrolidin-1-yl)methanone
Synonyms: 1-(4-Bromobenzoyl)pyrrolidine;4-(Pyrrolidinylcarbonyl)bromobenzene;(4-Bromophenyl)(pyrrolidin-1-yl)methanone;Methanone, (4-bromophenyl)-1-pyrrolidinyl-
CBNumber: CB51262116
Molecular Formula: C11H12BrNO
Formula Weight: 254.12
MOL File: 5543-27-1.mol

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(4-Bromophenyl)(pyrrolidin-1-yl)methanone Property

Melting point:: 77-79 °C
Boiling point:: 364.7±25.0 °C(Predicted)
Density: 1.469±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -1.42±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B678710
Product name: (4-Bromophenyl)(pyrrolidin-1-yl)methanone
Packaging: 50mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H17-9-18
Product name: 1-(4-Bromobenzoyl)pyrrolidine
Packaging: 1g
Price: $93
Updated: 2021/12/16

Oakwood

Product number: 091219
Product name: 1-(4-Bromobenzoyl)pyrrolidine
Purity: 98%
Packaging: 5g
Price: $94
Updated: 2021/12/16

Oakwood

Product number: 091219
Product name: 1-(4-Bromobenzoyl)pyrrolidine
Purity: 98%
Packaging: 1g
Price: $34
Updated: 2021/12/16

Matrix Scientific

Product number: 150346
Product name: (4-Bromophenyl)(pyrrolidin-1-yl)methanone
Purity: 95%
Packaging: 1g
Price: $136
Updated: 2021/12/16

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(4-Bromophenyl)(pyrrolidin-1-yl)methanone Chemical Properties,Usage,Production

Synthesis

123-75-1

586-75-4

5543-27-1

Example 40A Synthesis of (4-bromophenyl)pyrrolidin-1-ylmethanone: 4-bromobenzoyl chloride (3 g, 13.7 mmol) was dissolved in dichloromethane (25 mL) and cooled to 0°C. Pyrrolidine (2.5 mL, 30.3 mmol) and triethylamine (2 mL, 14.4 mmol) were added sequentially under stirring. The reaction mixture was slowly warmed up to room temperature over 3 hours. After completion of the reaction, the mixture was concentrated to remove the solvent. The crude product was purified by rapid chromatography on silica gel with an eluent gradient of 10-60% hexane/ethyl acetate to afford 4-(pyrrolizinylcarbonyl)bromobenzene (3.1 g, 89% yield). Mass spectrum (ESI) m/e 256 (M + H)+.

References

[1] Patent: US2007/259937, 2007, A1. Location in patent: Page/Page column 17
[2] Patent: US6340759, 2002, B1. Location in patent: Example 274
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53, # 8, p. 1115 - 1121
[4] Organic Letters, 2015, vol. 17, # 19, p. 4850 - 4853

(4-Bromophenyl)(pyrrolidin-1-yl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-Bromophenyl)(pyrrolidin-1-yl)methanone Suppliers

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