ChemicalBook > CAS DataBase List > (4-Bromophenyl)(pyrrolidin-1-yl)methanone
(4-Bromophenyl)(pyrrolidin-1-yl)methanone
- Product Name
- (4-Bromophenyl)(pyrrolidin-1-yl)methanone
- CAS No.
- 5543-27-1
- Chemical Name
- (4-Bromophenyl)(pyrrolidin-1-yl)methanone
- Synonyms
- 1-(4-Bromobenzoyl)pyrrolidine;4-(Pyrrolidinylcarbonyl)bromobenzene;(4-Bromophenyl)(pyrrolidin-1-yl)methanone;Methanone, (4-bromophenyl)-1-pyrrolidinyl-
- CBNumber
- CB51262116
- Molecular Formula
- C11H12BrNO
- Formula Weight
- 254.12
- MOL File
- 5543-27-1.mol
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(4-Bromophenyl)(pyrrolidin-1-yl)methanone Property
- Melting point:
- 77-79 °C
- Boiling point:
- 364.7±25.0 °C(Predicted)
- Density
- 1.469±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -1.42±0.20(Predicted)
- Appearance
- White to off-white Solid
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Safety
- Hazard Codes
- Xi
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TRC
- Product number
- B678710
- Product name
- (4-Bromophenyl)(pyrrolidin-1-yl)methanone
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H17-9-18
- Product name
- 1-(4-Bromobenzoyl)pyrrolidine
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
Oakwood
- Product number
- 091219
- Product name
- 1-(4-Bromobenzoyl)pyrrolidine
- Purity
- 98%
- Packaging
- 5g
- Price
- $94
- Updated
- 2021/12/16
Oakwood
- Product number
- 091219
- Product name
- 1-(4-Bromobenzoyl)pyrrolidine
- Purity
- 98%
- Packaging
- 1g
- Price
- $34
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 150346
- Product name
- (4-Bromophenyl)(pyrrolidin-1-yl)methanone
- Purity
- 95%
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
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(4-Bromophenyl)(pyrrolidin-1-yl)methanone Chemical Properties,Usage,Production
Synthesis
123-75-1
586-75-4
5543-27-1
Example 40A Synthesis of (4-bromophenyl)pyrrolidin-1-ylmethanone: 4-bromobenzoyl chloride (3 g, 13.7 mmol) was dissolved in dichloromethane (25 mL) and cooled to 0°C. Pyrrolidine (2.5 mL, 30.3 mmol) and triethylamine (2 mL, 14.4 mmol) were added sequentially under stirring. The reaction mixture was slowly warmed up to room temperature over 3 hours. After completion of the reaction, the mixture was concentrated to remove the solvent. The crude product was purified by rapid chromatography on silica gel with an eluent gradient of 10-60% hexane/ethyl acetate to afford 4-(pyrrolizinylcarbonyl)bromobenzene (3.1 g, 89% yield). Mass spectrum (ESI) m/e 256 (M + H)+.
References
[1] Patent: US2007/259937, 2007, A1. Location in patent: Page/Page column 17
[2] Patent: US6340759, 2002, B1. Location in patent: Example 274
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53, # 8, p. 1115 - 1121
[4] Organic Letters, 2015, vol. 17, # 19, p. 4850 - 4853
(4-Bromophenyl)(pyrrolidin-1-yl)methanone Preparation Products And Raw materials
Raw materials
Preparation Products
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