ChemicalBook > CAS DataBase List > 3-Amino-2-hydroxybenzoic acid methyl ester

3-Amino-2-hydroxybenzoic acid methyl ester

Product Name
3-Amino-2-hydroxybenzoic acid methyl ester
CAS No.
35748-34-6
Chemical Name
3-Amino-2-hydroxybenzoic acid methyl ester
Synonyms
Methyl 3-amino-2-hydroxybenzoate;Methyl 3-amino-salicylate;Methyl3-aminosalicylate,97%;Methyl 3-aMinosalicylate, 95%;3-Amino-2-hydroxybenzoic acid methyl ester;Benzoic acid,3-aMino-2-hydroxy-, Methyl ester;3-amino-2-hydroxy-Benzoic acid methyl ester (9CI ACI);Benzoic acid, 3-amino-2-hydroxy-, methyl ester (9CI, ACI);2-Hydroxy-3-(methoxycarbonyl)aniline, 2-Amino-6-(methoxycarbonyl)phenol
CBNumber
CB51263421
Molecular Formula
C8H9NO3
Formula Weight
167.16
MOL File
35748-34-6.mol
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3-Amino-2-hydroxybenzoic acid methyl ester Property

Melting point:
120℃ (dichloromethane )
Boiling point:
274.9±25.0 °C(Predicted)
Density 
1.305±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform, DMSO, Methanol
form 
Solid
pka
9.55±0.10(Predicted)
color 
Light Brown
InChI
InChI=1S/C8H9NO3/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4,10H,9H2,1H3
InChIKey
OMWQHVRUXLRZRC-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC=CC(N)=C1O
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Safety

Hazard Codes 
Xi
HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
A611275
Product name
3-Amino-2-hydroxybenzoicAcidMethylEster
Packaging
250mg
Price
$145
Updated
2021/12/16
Apolloscientific
Product number
OR01954
Product name
Methyl3-amino-2-hydroxybenzoate
Packaging
100mg
Price
$27
Updated
2021/12/16
Oakwood
Product number
066801
Product name
Methyl3-Amino-2-hydroxybenzoate
Purity
95%
Packaging
250mg
Price
$29
Updated
2021/12/16
Apolloscientific
Product number
OR01954
Product name
Methyl3-amino-2-hydroxybenzoate
Packaging
250mg
Price
$41
Updated
2021/12/16
SynQuest Laboratories
Product number
4658-1-X3
Product name
Methyl 3-amino-2-hydroxybenzoate
Packaging
250mg
Price
$45
Updated
2021/12/16
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3-Amino-2-hydroxybenzoic acid methyl ester Chemical Properties,Usage,Production

Uses

3-Amino-2-hydroxybenzoic Acid Methyl Ester is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.

Synthesis

22621-41-6

35748-34-6

The general procedure for the synthesis of methyl 3-amino-2-hydroxybenzoate from methyl 2-hydroxy-3-nitrobenzoate was as follows: a suspension of methyl 2-hydroxy-3-nitrobenzoate (18.1 g, 93 mmol) with 5% palladium carbon (5 g) in methanol (200 mL) was placed in a Parr flask at room temperature and shaken for 49 hr under hydrogen (60 psi) atmosphere. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth plug and the filtrate was concentrated under reduced pressure to remove the solvent to afford methyl 3-amino-2-hydroxybenzoate (15.6 g, yield > 99%) as a yellow solid. The structure of the product was confirmed by 1H NMR (CDCl3): δ 10.87 (s, 1H), 7.23 (dd, J = 7.7 Hz, 2H), 6.87 (t, J = 9.9 Hz, 1H), 3.95 (s, 3H), 3.80 (br s, 2H); ESI MS m/z 168 [C8H9NO3 + H]+.

References

[1] Patent: WO2004/63155, 2004, A1. Location in patent: Page 172
[2] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0138
[3] Patent: US2006/205718, 2006, A1. Location in patent: Page/Page column 73
[4] Patent: EP2959918, 2015, A1. Location in patent: Paragraph 0116
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937

3-Amino-2-hydroxybenzoic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Amino-2-hydroxybenzoic acid methyl ester manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
3-Amino-2-hydroxybenzoic acid methyl ester 35748-34-6
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-09
Career Henan Chemical Co
Product
3-Amino-2-hydroxybenzoic acid methyl ester 35748-34-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-25

35748-34-6, 3-Amino-2-hydroxybenzoic acid methyl esterRelated Search:

Carbomer Metabutoxycaine Methyl 3,5-dinitrosalicylate Methyl 3-amino-5-chloro-2-hydroxybenzoate METHYL 2-HYDROXY-3-NITROBENZOATE 3-Amino-2-hydroxybenzoic acid methyl ester 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE-8-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE METHYL 2,6-DIMETHOXY-3-NITROBENZOATE 1-AMINO-2-HYDROXY-NAPHTALENE-3-CARBOXYLIC ACID METHYL ESTER METHYL 3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-8-CARBOXYLATE 3-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER RARECHEM AL BF 0746 RARECHEM AL BI 0746 6-Trifluoromethoxy-3,4-dihydro-2Hbenzo[1,4]oxazine-8-carboxylic acid methyl ester 2-Hydroxy-3-amino-5-trifluoromethoxy-benzoic acid methyl ester 2-METHOXY-3-AMINO-4-TRIFLUOMETHYL METHYL CARBOXYLATE 2-Hydroxy-3-nitro-5-trifluoromethoxy-benzoic acid methyl ester RARECHEM AL BI 0272

  • 3-Amino-2-hydroxybenzoic acid methyl ester
  • Methyl 3-amino-2-hydroxybenzoate
  • 2-Hydroxy-3-(methoxycarbonyl)aniline, 2-Amino-6-(methoxycarbonyl)phenol
  • Methyl 3-aMinosalicylate, 95%
  • Benzoic acid,3-aMino-2-hydroxy-, Methyl ester
  • Methyl3-aminosalicylate,97%
  • Benzoic acid, 3-amino-2-hydroxy-, methyl ester (9CI, ACI)
  • 3-amino-2-hydroxy-Benzoic acid methyl ester (9CI ACI)
  • Methyl 3-amino-salicylate
  • 35748-34-6