3-Amino-2-hydroxybenzoic acid methyl ester
- Product Name
- 3-Amino-2-hydroxybenzoic acid methyl ester
- CAS No.
- 35748-34-6
- Chemical Name
- 3-Amino-2-hydroxybenzoic acid methyl ester
- Synonyms
- Methyl 3-amino-2-hydroxybenzoate;Methyl 3-amino-salicylate;Methyl3-aminosalicylate,97%;Methyl 3-aMinosalicylate, 95%;3-Amino-2-hydroxybenzoic acid methyl ester;Benzoic acid,3-aMino-2-hydroxy-, Methyl ester;3-amino-2-hydroxy-Benzoic acid methyl ester (9CI ACI);Benzoic acid, 3-amino-2-hydroxy-, methyl ester (9CI, ACI);2-Hydroxy-3-(methoxycarbonyl)aniline, 2-Amino-6-(methoxycarbonyl)phenol
- CBNumber
- CB51263421
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 35748-34-6.mol
3-Amino-2-hydroxybenzoic acid methyl ester Property
- Melting point:
- 120℃ (dichloromethane )
- Boiling point:
- 274.9±25.0 °C(Predicted)
- Density
- 1.305±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform, DMSO, Methanol
- form
- Solid
- pka
- 9.55±0.10(Predicted)
- color
- Light Brown
- InChI
- InChI=1S/C8H9NO3/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4,10H,9H2,1H3
- InChIKey
- OMWQHVRUXLRZRC-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC(N)=C1O
Safety
- Hazard Codes
- Xi
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A611275
- Product name
- 3-Amino-2-hydroxybenzoicAcidMethylEster
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- OR01954
- Product name
- Methyl3-amino-2-hydroxybenzoate
- Packaging
- 100mg
- Price
- $27
- Updated
- 2021/12/16
- Product number
- 066801
- Product name
- Methyl3-Amino-2-hydroxybenzoate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- OR01954
- Product name
- Methyl3-amino-2-hydroxybenzoate
- Packaging
- 250mg
- Price
- $41
- Updated
- 2021/12/16
- Product number
- 4658-1-X3
- Product name
- Methyl 3-amino-2-hydroxybenzoate
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
3-Amino-2-hydroxybenzoic acid methyl ester Chemical Properties,Usage,Production
Uses
3-Amino-2-hydroxybenzoic Acid Methyl Ester is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.
Synthesis
22621-41-6
35748-34-6
The general procedure for the synthesis of methyl 3-amino-2-hydroxybenzoate from methyl 2-hydroxy-3-nitrobenzoate was as follows: a suspension of methyl 2-hydroxy-3-nitrobenzoate (18.1 g, 93 mmol) with 5% palladium carbon (5 g) in methanol (200 mL) was placed in a Parr flask at room temperature and shaken for 49 hr under hydrogen (60 psi) atmosphere. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth plug and the filtrate was concentrated under reduced pressure to remove the solvent to afford methyl 3-amino-2-hydroxybenzoate (15.6 g, yield > 99%) as a yellow solid. The structure of the product was confirmed by 1H NMR (CDCl3): δ 10.87 (s, 1H), 7.23 (dd, J = 7.7 Hz, 2H), 6.87 (t, J = 9.9 Hz, 1H), 3.95 (s, 3H), 3.80 (br s, 2H); ESI MS m/z 168 [C8H9NO3 + H]+.
References
[1] Patent: WO2004/63155, 2004, A1. Location in patent: Page 172
[2] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0138
[3] Patent: US2006/205718, 2006, A1. Location in patent: Page/Page column 73
[4] Patent: EP2959918, 2015, A1. Location in patent: Paragraph 0116
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937
3-Amino-2-hydroxybenzoic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-2-hydroxybenzoic acid methyl ester manufacturers
- Product
- 3-Amino-2-hydroxybenzoic acid methyl ester 35748-34-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-09
- Product
- 3-Amino-2-hydroxybenzoic acid methyl ester 35748-34-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25